In work published in Nature, researchers’ structural insights help reveal a weak spot in malaria’s plan of attack which could help guide vaccine design.
A re-engineered wearable ultrasound patch for continuous and noninvasive blood pressure monitoring has undergone comprehensive clinical validation on over 100 patients, marking a major milestone in wearable technology research. The soft, stretchy patch provides precise, real-time readings of blood pressure deep within the body.
Mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.
A group of investigators led by Cedars-Sinai have developed and successfully tested a new artificial intelligence (AI) method to make launching cancer clinical trials easier and faster.
Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood. Molecular biologists Alexander Stockinger, Leonie Adelmann and Florian Raible from the Max Perutz Labs at the University of Vienna have now made an important contribution to clarifying this question in a new study.
The study findings point to the potential of interleukin-13 antibodies — approved for use in humans — as a treatment to protect against bacterial pneumonia in patients with zinc deficiency.
The rod-shaped tuberculosis (TB) bacterium, which the World Health Organization has once again ranked as the top infectious disease killer globally, is the first single-celled organism ever observed to maintain a consistent growth rate throughout its life cycle. These findings, reported by researchers on November 15 in the journal Nature Microbiology, overturn core beliefs of bacterial cell biology and hint at why the deadly pathogen so readily outmaneuvers our immune system and antibiotics.
MSU researchers now can identify more proteins, or biomarkers, in blood plasma, including those linked to specific diseases like cancer. By identifying these biomarkers earlier, medical researchers can create better diagnostic tests and drugs that target diseases sooner, improving patient outcomes.
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A new editorial – published in Nature – suggests that frequent fluctuations in diet, commonly known as "yo-yo dieting," can significantly increase the risk of cardiovascular disease. The authors, from the University of Pennsylvania Schools of Nursing and Medicine, describe how cycling between high-fat and low-fat diets in mice led to a substantial acceleration of atherosclerosis, a condition characterized by the buildup of plaque in arteries.
Researchers at Washington University School of Medicine in St. Louis have linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer’s genesis and progression. The proteins were gathered from cerebrospinal fluid and are a good proxy for activity in the brain. Several of them may be potential targets for therapies.
A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.
With the firearm deer hunting season kicking off this week, many Michigan hunters have their minds set on bringing home a winning whitetail deer. But for Sonja Christensen, an assistant professor in the Department of Fisheries and Wildlife in Michigan State University’s College of Agriculture and Natural Resources, the focus — now and all year long — is on protecting deer from disease.
Researchers have identified new roles for a protein long known to protect against severe flu infection – among them, raising the minimum number of viral particles needed to cause sickness.
A new study highlights how some marine life could face extinction over the next century, if human-induced global warming worsens.
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With year-on-year record breaking global temperatures, the health risks for vulnerable populations—especially pregnant women and newborns—are increasingly concerning.
Researchers at WashU Medicine have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to attack. Their study was published in Nature Genetics.
New MSK research marks a potential advance against RAS-driven cancers; breaks down data silos to better predict cancer outcomes with the help of artificial intelligence (AI); identifies two enzymes vital for maintaining brain health; uncovers how changes to “helper” proteins drive cancer cell survival; develops a new model for investigating lung cancer metastasis; and uses AI to improve outcome predictions in sarcoma.
Mount Sinai researchers have discovered for the first time a neural mechanism for memory integration that stretches across both time and personal experience.
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