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Released: 25-Apr-2022 9:50 AM EDT
Experimental Evidence for Rare Quantum Disordered Phase in Cerium-Based Magnet Ce2Zr2O7
 McMaster University

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Newswise: Combination Immunotherapy Improves Outcomes for Patients with Non-small Cell Lung Cancer
Released: 25-Apr-2022 9:45 AM EDT
Combination Immunotherapy Improves Outcomes for Patients with Non-small Cell Lung Cancer
Yale Cancer Center/Smilow Cancer Hospital

The phase 2 clinical trial of a multi-center study known as the COAST clinical trial has demonstrated improved outcomes using immunotherapy combinations for patients with unresectable stage III non-small cell lung cancer, according to researchers at Yale Cancer Center and participating organizations.

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Newswise: Científicos descubren escurridizo gas de galaxias post brote estelar que se escondía a plena vista
22-Apr-2022 10:40 AM EDT
Científicos descubren escurridizo gas de galaxias post brote estelar que se escondía a plena vista
 National Radio Astronomy Observatory

Se creía que las galaxias post brotes de formación estelar agotan a gran velocidad y en violentas erupciones de energía todo el polvo y gas necesario para fabricar estrellas. Los nuevos datos obtenidos por el Atacama Large Millimeter/submillimeter Array (ALMA) revelaron que, en realidad, estas galaxias no se despojan de todo su combustible, sino que entran en un letargo en el que conservan y comprimen grandes cantidades de gas ultraconcentrado y turbulento. No obstante, al contrario de lo que se esperaría, tampoco lo usan para dar nacimiento a nuevas estrellas.

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Newswise: Scientists Find Elusive Gas From Post-starburst Galaxies Hiding in Plain Sight
22-Apr-2022 10:35 AM EDT
Scientists Find Elusive Gas From Post-starburst Galaxies Hiding in Plain Sight
 National Radio Astronomy Observatory

Post-starburst galaxies were previously thought to scatter all of their gas and dust—the fuel required for creating new stars—in violent bursts of energy, and with extraordinary speed. Now, new data from the Atacama Large Millimeter/submillimeter Array (ALMA) reveals that these galaxies don’t scatter all of their star-forming fuel after all. Instead, after their supposed end, these dormant galaxies hold onto and compress large amounts of highly-concentrated, turbulent gas. But contrary to expectation, they’re not using it to form stars.

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Released: 25-Apr-2022 8:05 AM EDT
New White Paper on Prosecution of Child Sexual Abuse: Challenges in Achieving Justice
 Wellesley College, Wellesley Centers for Women

This white paper delves into the factors that impact whether cases of child sexual abuse move forward to prosecution. It makes actionable recommendations for achieving justice for all involved and for strengthening the safety of communities.

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Newswise: Jiminy's wings turned out as fine as his conscience
Released: 25-Apr-2022 8:00 AM EDT
Jiminy's wings turned out as fine as his conscience
 Kyoto University

Three intercellular pathways in crickets signal the formation of dorsal wings.

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Newswise:Video Embedded study-finds-surprising-way-to-make-walking-easier
VIDEO
Released: 25-Apr-2022 6:00 AM EDT
Study Finds Surprising Way to Make Walking Easier
 Philippe Malcolm, PhD

A robotic waist tether pulls at a wearer’s center of mass to reduce the energy needed to walk, offering a new potential approach for assistive rehabilitation.

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Released: 25-Apr-2022 4:00 AM EDT
Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders
 Immunologic Research

… There was a statistically significant difference in the frequency of CD4+ CD95+, CD4+ CD95 Hi, and CD4+ CD95 low/med T stem cell memory (T SCM) cells between responder and nonresponder groups. However, the comparison of the …

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Released: 25-Apr-2022 4:00 AM EDT
Central nervous system infection with Seoul Orthohantavirus in a child after hematopoietic stem cell transplantation: a case report
 Virology Journal

… The child was pretreated with modified Bu/Cy plus ATG regimen for transplantation, and underwent haploid hematopoietic stem cell … , intravenous immunoglobulin (IVIG) transfusion, stem cell transfusion and other treatments, and …

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Released: 25-Apr-2022 4:00 AM EDT
Mesenchymal Stem Cell Treatment Restores Liver Macrophages Homeostasis to Alleviate Mouse Acute Liver Injury Revealed by Single-cell Analysis
 Pharmacological Research

Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem cells (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages …

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Released: 25-Apr-2022 4:00 AM EDT
The combined therapy of mesenchymal stem cell transplantation and resveratrol for diabetes: Future applications and challenges
 Life Sciences

… MSC, a pluripotent stem cell, has self-renewal capability and multidirectional differentiation potential, and it can be obtained from tissues, such as the umbilical cord, bone marrow and fat [24], [25]. Many experimental and clinical studies proved …

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Released: 25-Apr-2022 4:00 AM EDT
Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests
 Stem Cells Translational Medicine

Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic …

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Released: 25-Apr-2022 4:00 AM EDT
Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiation
 Science Advances

… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …

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Released: 25-Apr-2022 4:00 AM EDT
Mesenchymal Stem Cell Therapy in the Treatment of Neurodegenerative Cerebellar Ataxias: a Systematic Review and Meta-analysis
 The Cerebellum

… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …

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Released: 25-Apr-2022 4:00 AM EDT
ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage
 Nature Communications

… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …

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Released: 25-Apr-2022 4:00 AM EDT
Microbial–stem cell interactions in periodontal disease
 Journal of Medical Microbiology

… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …

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Newswise: Water Processing: Light Helps Degrade Hormones
Released: 25-Apr-2022 3:05 AM EDT
Water Processing: Light Helps Degrade Hormones
 Karlsruhe Institute of Technology (KIT)

Micropollutants in water often are hormones that accumulate in the environment and may have negative impacts on humans and animals. Researchers of Karlsruhe Institute of Technology (KIT) and Leibniz Institute of Surface Engineering (IOM) in Leipzig have now developed a process for the photocatalytic degradation of these pollutants when they flow through polymer membranes. It is presented in Nature Nanotechnology. Irradiation with light triggers a chemical reaction, as a result of which steroid hormones are degraded on the membranes coated with titanium dioxide. (DOI: 10.1038/s41565-022-01074-8)

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Released: 25-Apr-2022 2:10 AM EDT
Decoding Human Hematopoietic Stem Cell Self-Renewal
 Current Stem Cell Reports

… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …

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Released: 25-Apr-2022 2:10 AM EDT
Current Status and Perspectives of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia
 Stem Cells Translational Medicine

As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …

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Released: 25-Apr-2022 2:10 AM EDT
Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II)
 Stem Cells Translational Medicine

… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …

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