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Released: 25-Apr-2022 2:10 AM EDT
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model
Nature Communications

… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …

Released: 25-Apr-2022 2:10 AM EDT
Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes
Nature Communications

… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …

Released: 25-Apr-2022 2:10 AM EDT
Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population
Nature Communications

The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …

Released: 25-Apr-2022 2:10 AM EDT
Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: a protocol for a systematic review and meta-analysis
Systematic Reviews

… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …

Released: 25-Apr-2022 2:10 AM EDT
A systematic review of large animal and human studies of stem cell therapeutics for acute adult traumatic spinal cord injury
Journal of Orthopaedics, Trauma and Rehabilitation

… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …

Released: 25-Apr-2022 2:10 AM EDT
Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent
Chemico-Biological Interactions

In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …

Released: 25-Apr-2022 2:10 AM EDT
Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila
Cell Reports

… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …

21-Apr-2022 4:05 PM EDT
Mayo Clinic study confirms living kidney donor surgery is low risk for most patients
Mayo Clinic

The risk of major complications for people who donate a kidney via laparoscopic surgery is minimal. That is the conclusion of a 20-year Mayo Clinic study of more than 3,000 living kidney donors. Only 2.5% of patients in the study experienced major complications, and all recovered completely.

Released: 25-Apr-2022 12:00 AM EDT
A person-centred intervention remotely targeting family caregivers’ support needs in the context of allogeneic hematopoietic stem cell transplantation - a feasibility study
Preprints

Annika M Kisch, Karin Bergkvist, Sólveig Adalsteinsdóttir, Christel Wendt, Anette Alvariza, Jeanette Winterling

Released: 25-Apr-2022 12:00 AM EDT
Prognostic implications of MUC1 and XBP1 concordant expression in multiple myeloma: A retrospective study
Preprints

Sheerien Rajput, Khurram Minhas, Iqbal Azam, Usman Shaikh, El-Nasir Lalani

Released: 25-Apr-2022 12:00 AM EDT
Human PMSCs derived exosomes alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model
Preprints

Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao

Released: 25-Apr-2022 12:00 AM EDT
Molecular Imaging (PET and SPECT) for Children with Hypoxic-ischemic-encephalopathy and Cerebral Palsy before and after cell therapy
Preprints

Toshinobu Nakatake, Makoto Nabetani, Nanae Yutaka, Kaho Suzuki, Ryoichi Hazama, Satoshi Ohnishi, Takashi Hamazaki, Haruo Shintaku, Ran D Goldman

Released: 25-Apr-2022 12:00 AM EDT
Induction of human pluripotent stem cells from human somatic cells by chemical reprogramming
Preprints

Hongkui Deng, Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, GaoFan Meng, Jialiang Zhu, Yanglu Wang, Shijia Liuyang, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen

Released: 25-Apr-2022 12:00 AM EDT
Functional stemness-related genes revealed by single-cell profiling of naïve and stimulated human CD34 + cells from CB and mPB
Preprints

GuoYi Dong, Xiaojing Xu, Yue Li, Wenjie Ouyang, Weihua Zhao, Ying Gu, Jie Li, Tianbin Liu, Xinru Zeng, Huilin Zou, Shuguang Wang, Sixi Liu, Hai-Xi Sun, Chao Liu

Released: 25-Apr-2022 12:00 AM EDT
Taurine promotes differentiation and maturation of neural stem/progenitor cells from the subventricular zone via activation of GABAA receptors
Preprints

Lenin D. Ochoa-De la Paz, Nadia Estefanía Gutiérrez-Castañeda, Jessica González-Corona, Ernesto Griego, Emilio J. Galván

Released: 25-Apr-2022 12:00 AM EDT
Mitochondrial transfer alters cell fate by remodeling metabolic processes to regulate bone homeostasis
Preprints

Yufeng Zhang, Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, YaoTing Ji

Released: 25-Apr-2022 12:00 AM EDT
The Impact of COVID-19 on Autologous Stem Cell Transplantation in Multiple Myeloma A single-centre service evaluation
Preprints

Marquita Camilleri, Georgios Bekris, Govundeep Sidhu, Caroline Buck, Esme Elsden, Orla McCourt, Jackie Horder, Fiona Newrick, Catherine Lecat, Jonathan Sive, Xenofon Papanikolaou, Rakesh Popat, Lydia Lee, Ke Xu, Charalampia Kyriakou, Neil Rabin, Kwee Yong, Abi Fisher

Released: 25-Apr-2022 12:00 AM EDT
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
Preprints

Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Kunal Goutam, Chanakya Nath Kundu

22-Apr-2022 5:05 AM EDT
New research shows humans possess surprising nutritional intelligence
University of Bristol

Pioneering research has shed new light on what drives people’s basic food preferences, indicating our choices may be smarter than previously thought and influenced by the specific nutrients, as opposed to just calories, we need.

   


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