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Guidelines experts reviewed existing research and conducted their own to present a framework for developing living practice guidelines in health care. The framework provides specific instruction for the planning, production, reporting, and dissemination of such guidelines and highlights the considerations specific to each of those areas in the context of a living document. The advice is published in Annals of Internal Medicine.

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A randomized study of adult Medicaid patients suggests that social program-based interventions for housing, food security, and transportation may reduce inpatient admission rates by 11 percent and emergency department visits by 4 percent. However, health care savings based on these interventions may not cover the cost of social the social programs. The findings are published in Annals of Internal Medicine.

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A cross sectional study found that substantial discrepancies exist between individual estimated glomerular filtration rate (eGFR) and directly measured GFR (mGFR). Laboratory reports that provide eGFR calculations should consider including the distribution of this uncertainty. According to the authors, renaming the eGFR as a population average GFR (or paGFR) merits further discussion. The findings are published in Annals of Internal Medicine.

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The failure of diseased adult heart to regenerate is a major burden to our societies. Besides patients with ischemia and left ventricular (LV) dysfunction, progress in pediatric surgery to repair cardiac malformations has led to a growing population of now adult congenital heart diseases (CHD) patients with right ventricular (RV) failure.

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Rett syndrome (RTT) is a rare disease and one of the most abundant causes for intellectual disa-bilities in females. Single mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2), are responsible for the disease.

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Intratumoral heterogeneity can exist along multiple axes: Cancer Stem Cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states and a spectrum of epithelial-hybrid-mesenchymal phenotypes.

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WNT binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts have enabled us to shed light on WNT-FZD pharmacology in overexpressed HEK293 cell systems.

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Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration.

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Nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional gene expression regulation mechanism in eukaryotic cells.