New insights into the process of DNA-looping change our view of how the genome is organised within cells. The discoveries by IMP-researchers elucidate a fundamental mechanism of life and settle a decade long scientific dispute.
According to a new Cell study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going — elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
Earlier this year, the call went out to the worldwide scientific community to submit their most beautiful and intriguing images and videos created using green fluorescent protein (GFP), the glowing molecule that revolutionized cell imaging 25 years ago. Now the votes are in, and the American Society for Cell Biology (ASCB), its Public Information Committee, and the public have determined the winners in each category.
After heart attack, ALX/FPR2 is activated by resolvin D1 in immune cells in the spleen and at the heart attack site. This speeds resolution of the heart injury. Research with mice that completely lack ALX/FPR2 reveals more about the pathways this resolution sensor uses to target inflammation.
UC San Diego researchers describe how circular extrachromosomal DNA in cancer cells boosts aggressiveness and resistance to therapies.
Two high school students developed software to analyze images of diatoms—algae that produce silicon for constructing cell walls—to determine the differences between wild and genetically modified strains of these organisms. This work was instrumental to a research team interested in optimizing diatoms for biomineralization, the process of making materials from biological systems.
Plants get stressed too. Environmental factors such as drought or a high concentration of salt in the soil disrupt their physiology.
Multiple myeloma is a type of blood cancer in which malignant plasma cells accumulate in the bone marrow, and recent studies have shown that some can leave the marrow and enter the blood stream. Until now, it has been difficult to detect these cells, known as clonal circulating plasma cells, in the blood.
Sequencing a genome doesn't necessarily reveal the functions of individual genes. An Iowa State University scientist helps to organize a competition to evaluate the accuracy of software programs that predict gene function. The recently published results of the latest competition included 144 entries from 68 teams.
A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell – nucleotide metabolism – to help identify new drugs that specifically and potently block processes that are essential for cancer cell growth.
Cornell researchers have uncovered the structure of a regulatory mechanism unique to bacteria, opening the door for designing new antibiotics targeted to pathogens.
Indiana University researchers have identified how two immune receptors coordinate closely to trigger a powerful response against fungal invaders, which could help advance research on cancer therapies.
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.
Researchers at the University of Delaware, using the revolutionary new genetic technology known as CRISPR/Cas9 have found a way to improve the efficiency and precision of the way enzymes work together to produce certain biochemical reactions in cells. Their new application essentially creates a dynamic assembly line that can lead to advances in pharmaceuticals, agriculture and biofuels.
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition
Researchers from the University of California, Irvine developed a breakthrough cell therapy to improve memory and prevent seizures in mice following traumatic brain injury. The study, titled “Transplanted interneurons improve memory precision after traumatic brain injury,” was published today in Nature Communications.
New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness
Researchers identified non-coding regions of the human genome that control the development and function of four brain cell types and mapped genetic risk variants for psychiatric diseases. They found that risk variants for Alzheimer’s disease were enriched in microglia-specific regulatory elements.
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