Curated News: Cell (journal)

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A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.

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UT Southwestern immunologists have uncovered a key pathogenic event prompted by obesity that can trigger severe forms of nonalcoholic fatty liver disease and potential liver failure.

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High levels of ammonia in tumors leads to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed. Researchers found that ammonia inhibits the growth and function of T cells, which are vital for anti-tumor immunity. The findings appear in Cell Metabolism.

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Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels.

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Modern humans evolutionarily split from our chimpanzee ancestors nearly 7 million years ago, yet we are continuing to evolve.

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A brief roundup of news and story ideas from the experts at UCLA Health.

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Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells—cells that control your heartbeat—can “fight back” against therapies to biologically correct abnormal heartbeat rates.

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Neuroscience graduate students at Children’s Hospital Los Angeles have developed an automated method that could save time and work for laboratories around the country by streamlining the process of identifying and mapping brain cells. Scientists want to understand how brain cells develop over time because the way these cells, called neurons, develop, influences how they function, or how they malfunction in neurodevelopmental disorders.

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Female bees and wasps use modified ovipositors, formerly used in egg laying, to sting their attackers, including people.

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Researchers from Boston Children’s Hospital and Harvard, using Argonne’s Advanced Photon Source, have characterized the structure of integrins, a type of cell surface receptor involved in the immune response.

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Climate change, rather than competition, played a key role in the ascendancy of dinosaurs through the Late Triassic and Early Jurassic periods.

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Scientists at Johns Hopkins Medicine say they have developed a computer model — dubbed quantitative fate mapping — that looks back in the developmental timeline to trace the origin of cells in a fully grown organism.

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The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been devastating the entire world.

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From the excitable sheep dog to the aloof Shiba Inu, and all breeds in between, dogs have unique and diverse behavioral traits.

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A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.

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Investigators at Cedars-Sinai conduct more than 2,500 research projects annually, and many of these studies have resulted in new treatments or have opened the door to future innovations.

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"Vaccines such as JYNNEOS should be able to induce T cells that also recognize mpox and can provide protection from severe disease."