Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor’s potential resistance to a drug, and then identified a drug combination that reversed that resistance.
One of the WHO’s three critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers from the Department of Chemistry - University of Warwick have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.
Scientists at the University of Surrey have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria.
Studying natural defenses in maize, a staple of diets around the world, UC San Diego biologists describe how they combined an array of scientific approaches to clearly define six genes that encode enzymes responsible for the production of key maize antibiotics known to control disease resistance.
Scientists obtained a total of 733 pathogen isolates from 171 individual wild Bottlenose dolphins in Florida and found that the overall prevalence of resistance to at least one antibiotic for the 733 isolates was 88.2 percent. Resistance was highest to erythromycin, followed by ampicillin. It is likely that these isolates from dolphins originated from a source where antibiotics are regularly used, potentially entering the marine environment through human activities or discharges from terrestrial sources.
Wistar has received a grant of approximately $4.6 million from the National Institutes of Health in support of innovative research to tackle antibiotic resistance.
In this newly published paper authors Hui Li, Ph.D., and Pak King Wong, Ph.D., (The Pennsylvania State University, PA, USA), Michael Morowitz, Ph.D., (University of Pittsburgh, PA, USA) and Neal Thomas, Ph.D., (Penn State University, PA, USA) describe their development of a novel technology approach designed to help clinicians better manage bacterial infection diagnosis and treatment, reduce the improper use of antibiotics and limit the spread of drug-resistant organisms.
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
A team of researchers led by the University of South Australia has discovered a way to find and beat superbugs, providing a critical breakthrough against many deadly infectious diseases.
In small, community hospitals that don’t have resources for a dedicated staff to oversee the proper use of antibiotics, turning to staff pharmacists showed promise in a model study conducted by Duke Health.
Staphylococcus aureus bacteria are a major cause of serious infections that often persist despite antibiotic treatment, but scientists at the UNC School of Medicine have now discovered a way to make these bacteria much more susceptible to some common antibiotics.
The study is the first to put antibiotic biosynthesis and resistance into an evolutionary context. The findings will help to guide the future discovery of new antibiotics and antibiotic alternatives which are medicines that are vitally needed given the current global threat of antimicrobial resistance.
Resistance to two critical antibiotic types, one a “drug of last resort” when all others fail against some “superbugs,” are widely distributed in Southeast Asia, raising the risk of untreatable infections, say a team of investigators led by Georgetown University Medical Center.
OS-MRSA has created confusion in clinical laboratories for the past decade because of its difficulty to diagnose. Findings of a new study identified a way to detect what an important gene has been hiding that could be critical for the successful treatment of the superbug.
The Centers for Medicare and Medicaid Services Inpatient Prospective Payment System rule for the coming fiscal year will raise reimbursements for novel antibiotics, a meaningful step in confronting the threat of infections resistant to older medicines. At the same time, the rule does not require or support antibiotic stewardship in healthcare settings, also an essential measure to protect the effectiveness of existing infection-fighting medicines.
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health examined independent charity prescription drug assistance programs in the U.S. and found that nearly all—97 percent—did not provide coverage for uninsured patients.
A new study by researchers at Intermountain Healthcare has found that administering broad-spectrum antibiotics, which act against a wide range of disease-causing bacteria, to treat patients with pneumonia often does more harm than good.
Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to draw natural killer immune cells to cancer cells.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
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