Feature Channels: Drug Resistance

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That pile of soil you bought at the home improvement store may contain more than just dirt, according to new research from the University of Georgia. A new UGA study found high levels of multidrug-resistant fungi in commercially available compost, soil and flower bulbs. Aspergillus fumigatus is a widespread fungus that thrives in soil. But it also poses a serious risk to human health if inhaled. People with compromised immune systems are particularly vulnerable to the opportunistic fungus, facing a near 100% fatality rate if infected with a multidrug-resistant strain.

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For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light.

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Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.

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Scientists at St. Jude Children’s Research Hospital uncovered a route to blocking activity of protein notorious for eliminating drugs, offering a potential boon to cancer therapy.

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Over 150 researchers from across the University of Utah gathered to form new connections and share groundbreaking research on topics from antibiotic resistance to autoimmune diseases.

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New study details long-sought mechanisms and structures

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Polymer-based hydrogels are used to treat skin ailments and in tissue engineering because of their ability to retain water, deliver drugs into wounds, and biodegrade. However, they are complicated to manufacture and not very resilient to external forces like rubbing against clothing, sheets, or wound dressings.

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A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

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A global wave of infections caused by fungi growing drug-resistant has the medical community issuing precautions on how to protect yourself.

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Patients with some types of lymphoma that become resistant to standard treatments may benefit from a therapy that University of Wisconsin–Madison researchers are evaluating after they discovered a key process that fuels the blood cancers’ resistance to current drugs.

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Heightened use of social media during the coronavirus pandemic brought with it an unprecedented surge in the spread of misinformation.

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Stay informed! These are the latest research articles on "Long COVID" from the Coronavirus News Source on Newswise.

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RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments - pharmacophores - are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.

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New drug inspired by images that captured how bacteria block antibiotic activity

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Aunque la cirugía puede ser una opción para hasta el 40% de las personas con epilepsia resistente a los medicamentos, menos del 1% son remitidos a centros de epilepsia cada año. ¿Por qué?

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Surgery may be an option for up to 40% of people with drug-resistant epilepsy, but fewer than 1% are referred to epilepsy centers each year. Why?

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Scientists have learned more about how drug resistance develops in patients with acute myeloid leukemia and how the process might be slowed, thanks to a study of proteins and other molecular players.