Research in mouse cells identifies defective metabolic pathway in aging immune T cells. The pathway is critical for switching T cells from dormancy into illness-fighting mode. In experiments, researchers restored lagging T-cell function by adding small-molecule compounds. Findings suggest possible mechanism behind weakened immunity common in the elderly.
A multi-country study finds that large portion sizes in fast food and full service restaurants is not a problem unique to the U.S. The researchers found that 94 percent of full service meals and 72 percent of fast food meals studied in five countries contained 600 calories or more.
Research in mice identifies a set of neurons responsible for sustained pain and resulting pain-coping behaviors. Findings point to the existence of separate neural pathways that regulate threat avoidance versus injury mitigation Existence of separate pathways may account for failure to develop effective pain medications Study can inform new ways to gauge the efficacy of candidate pain therapies by assessing behaviors stemming from different pathways
BIDMC researchers demonstrated that the lack of claudin 18 prompts the development of precancerous, abnormal cells and polyps in the engineered mouse model.
In a UK-wide survey published in the journal PLOS ONE, researchers at Beth Israel Deaconess Medical Center (BIDMC), and colleagues investigated primary care physicians’ views on AI’s looming impact on health professions.
A team of researchers from France, Sweden, and Denmark have identified a new strain of Yersinia pestis, the bacteria that causes plague, in DNA extracted from 5,000-year-old human remains. Their analyses, publishing December 6 in the journal Cell, suggest that this strain is the closest ever identified to the genetic origin of plague.
New study shows low use of telehealth services for substance use disorder. More than 20 million Americans have substance use disorders related to alcohol, opioids and other drugs. Less than one in five receive treatment for substance use disorder, in part because of lack of providers, especially in rural areas. Telehealth—which allows clinicians to evaluate and treat patients via video conferencing—could help fill this unmet need, but increasing use must overcome regulatory barriers and target rural areas.
In a new study published in the Journal of Clinical Oncology, Manuel Hidalgo, MD, PhD, and colleagues conducted a phase I/II trial designed to evaluate the efficacy and safety of nab-paclitaxel given in combination with gemcitabine in patients with pancreatic cancer and reduced health status. The team – based at the Centro Nacional de Investigaciones Oncologicas (Spanish National Cancer Center), where Hidalgo previously served as Director of the Clinical Research Program and Vice Director of Translational Research – reported that the combination of therapies significantly improved survival even in less robust patients with metastatic pancreatic ductal adenocarcinoma (PDAC) compared to gemcitabine alone.
The D’Amore-McKim School of Business recently welcomed Venkat Kuppuswamy as an assistant professor in the Entrepreneurship and Innovation group.
D’Amore-McKim is pleased to congratulate Ruth V. Aguilera, Distinguished Professor in International Business and Strategy, on her recent induction as Fellow to the Strategic Management Society (SMS).
The D’Amore-McKim School of Business recently welcomed Razvan Lungeanu as an assistant professor in the Entrepreneurship & Innovation group.
Dana-Farber Cancer Institute scientists will present research marking significant advances against the hematologic cancer multiple myeloma at the ASH Annual Meeting.
Improving outcomes for patients with myeloid cancers who undergo stem cell transplantation is a focus of several studies to be presented by Dana-Farber Cancer Institute scientists at the ASH Annual Meeting.
A research team has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features of cancerous cells found in patients’ urine by developing a nanoscale resolution map of the cells’ surface.
On Saturday, December 1, scientists attending the Gravitational Wave Physics and Astronomy Workshop in College Park, Maryland, presented new results from the National Science Foundation's LIGO (Laser Interferometer Gravitational-Wave Observatory) and the European- based VIRGO gravitational-wave detector regarding their searches for coalescing cosmic objects, such as pairs of black holes and pairs of neutron stars. The LIGO and Virgo collaborations have now confidently detected gravitational waves from a total of 10 stellar-mass binary black hole mergers and one merger of neutron stars, which are the dense, spherical remains of stellar explosions. Six of the black hole merger events had been reported before, while four are newly announced.
You may remember a loved one making you a bowl of chicken noodle soup whenever you were feeling under the weather as a child. Just how healthy is this culinary cure-all? BIDMC clinical dietitian Sandy Allonen, RD, weighs in.
New results from clinical trials of immunotherapy and experimental targeted agents for patients with leukemia and lymphoma are being presented by Dana-Farber Cancer Institute researchers at the ASH Annual Meeting.
Large international study confirms measuring bone microarchitecture with new imaging technology accurately predicts risk of fracture in older women and men
A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) investigated rates of bloodstream infection among patients with or without catheters in outpatient hemodialysis facilities in New England.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
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