Feature Channels: Stem Cells

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Released: 5-Jan-2022 8:55 AM EST
Mouse Mesenchymal Stem Cell-derived Exosomal Mir-466f-3p Reverses Emt Process Through Inhibiting Akt/gsk3β Pathway via C-met in Radiation-induced Lung Injury
Preprints

Yi Li, Zhufu Shen, Xiao Jiang, Yuanyuan Wang, Zuozhang Yang, YuChi Mao, Zhixian Wu, Gaofeng Li, Hong Chen

Released: 5-Jan-2022 8:55 AM EST
miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer
Preprints

Mithil Soni, Ozge Saatci, Gourab Gupta, Yogin Patel, Manikanda Raja Keerthi Raja, Jie Li, Xinfeng Liu, Peisheng Xu, Hongjun Wang, Daping Fan, Ozgur Sahin, Hexin Chen

Released: 5-Jan-2022 8:55 AM EST
B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors
Preprints

Daniel F Kaemena, Masahito Yoshihara, James Ashmore, Meryam Beniazza, Suling Zhao, Marten Bertenstam, Victor Olariu, Shintaro Katayama, Keisuke Okita, Simon Tomlinson, Kosuke Yusa, Keisuke Kaji

Released: 4-Jan-2022 12:00 PM EST
The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance
Preprints

Ishara S Ariyapala, Kasun Buddika, Heather A Hundley, Brian Calvi, Nicholas Sokol

Released: 4-Jan-2022 12:00 PM EST
Dissection of cellular communication between human primary osteoblasts and bone marrow mesenchymal stem cells in vivo at single-cell resolution
Preprints

Ying Liu, Yan Chen, Xiao-Hua Li, Tian-Peng Li, Chong Cao, Hui-Xi Zhang, Cui Zhou, Yu Chen, Yun Gong, Zun Wang, Xiang Qiu, Jun-Xiao Yang, Liang Cheng, Xiang-Ding Chen, Hui Shen, Hong-Mei Xiao, Li-Jun Tan, Hong-Wen Deng

Released: 4-Jan-2022 12:00 PM EST
Fasting Induces a Highly Resilient Deep Quiescent State in Muscle Stem Cells via Ketone Body Signaling
Preprints

Daniel I Benjamin, Pieter I Both, Joel S Benjamin, Christopher W Nutter, Jenna H Tan, Jengmin I Kang, Leo A Machado, Julian D.D Klein, Antoine de Morree, Soochi I Kim, Ling I Liu, Hunter Dulay, Ludovica Feraboli, Sharon M Louie, Daniel K Nomura, Thomas A Rando

Released: 4-Jan-2022 12:00 PM EST
The cluster structure function
Preprints

Andrew R. Cohen, Paul M. B. Vitányi

Released: 4-Jan-2022 12:00 PM EST
Histone deacetylase inhibitor overrides the effect of soft hydrogel on the mechanoresponse of human mesenchymal stem cells
Preprints

Rohit Joshi, Pooja Murlidharan, Puspendra Yadav, Vedanshi Dharnidharka, Abhijit Majumder

Released: 4-Jan-2022 12:00 PM EST
hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function
Preprints

Homa Majd, Ryan M Samuel, Jonathan T Ramirez, Ali Kalantari, Kevin Barber, Zaniar Ghazizadeh, Angeline K Chemel, Andrius Cesiulis, Mikayla N Richter, Subhamoy Das, Matthew G Keefe, Jeffrey Wang, Rahul Shiv, Conor J McCann, Samyukta Bhat, Matvei Khoroshkin, Johnny Yu, Tomasz J. Nowakowski, Hani Goodarzi, Nikhil Thapar, Julia A Kaltschmidt, Faranak Fattahi

Released: 4-Jan-2022 12:00 PM EST
Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing
Preprints

Nicolas Pelaez-Llaneza, Victoria Jones, Christy Kam, Alvin Lee, Alyson Parris, Sean Tattan, Martin Loader, Jordan Champion, George Russam, Ben Miller, Nathalie Juge, Richard Wharton, Christopher Speakman, Sandeep Kapur, James Hernon, Adam Stearns, Irshad Shaik, Anatu Pal, Alexia Tsigka, Diogenis Batsoulis, Mark R Williams

Released: 3-Jan-2022 12:00 PM EST
Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
Preprints

Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen

Released: 3-Jan-2022 12:00 PM EST
Porous Cellulose-Collagen Scaffolds For Soft Tissue Regeneration: Influence of Cellulose Derivatives On Mechanical Properties And Compatibility With Adipose-Derived Stem Cells
Preprints

Katarína Kacvinská, Martina Trávničková, Lucy Vojtová, Petr Poláček, Jana Dorazilová, Martin Kohoutek, Júlia Pajorová, Mária Tirpáková, Lucie Bačáková

Released: 3-Jan-2022 8:55 AM EST
Rapid Differentiation From Human Induced Pluripotent Stem Cells Into Functional Oligodendrocytes Using Synthetic Modified Olig2 mRNA
Preprints

Jian Xu, Rui Wang, Jingxin Zhao, Fumei He, Yidi Zhang, Yuan Xie, Lan Shen, Yichu Nie, Wenbin Deng

Released: 3-Jan-2022 8:55 AM EST
LncRNA-KCNQ1OT1 Promotes the Odontoblastic Differentiation of Dental Pulp Stem Cells via Regulating miR-153-3p/RUNX2 Axis
Preprints

Xiaohui Lu, Jiawen Zhang, Yuanzhou Lu, Jing Xing, Min Lian, Guijuan Feng, Dan Huang, Chenfei Wang, Nimei Shen, Xingmei Feng

Released: 3-Jan-2022 8:55 AM EST
H3K27me3 at Pericentromeric Heterochromatin is a Defining Feature of the Early Mouse Blastocyst
Preprints

Mélanie Pailles, Mélanie Hirlemann, Vincent Brochard, Martine Chebrout, Jean-François Oudin, Alice Jouneau, Amélie Bonnet-Garnier

Released: 3-Jan-2022 8:55 AM EST
Cellular and gene expression patterns associated with root bifurcation in Selaginella
Preprints

Tom Beeckman, Tao Fang, Hans Motte, Boris Parizot, Wouter Smet, Xilan Yang, Liam Walker, Maria Njo, George Bassel

Released: 3-Jan-2022 8:55 AM EST
Distinct roles of core autophagy-related genes (ATGs) in zebrafish definitive hematopoiesis
Preprints

Xiang-Ke Chen, Zhen-Ni Yi, Jack Jark-Yin Lau, Alvin Chun-Hang Ma

Released: 3-Jan-2022 8:55 AM EST
Anticancer, Antioxidant Activities and Molecular Docking Study of Thiazolidine -4-one and Thiadiazol Derivatives
Preprints

Tahseen Abdul Qader Alsalim, Noor M. Nasir, Amr Ahmed El-Arabey, Mohnad Abdalla

Released: 3-Jan-2022 8:55 AM EST
Dynamic evolution of small signaling peptide compensation in plant stem cell control
Preprints

Choon-Tak Kwon, Lingli Tang, Xingang Wang, Iacopo Gentile, Anat Hendelman, Gina Robitaille, Joyce Van Eck, Cao Xu, Zachary Lippman

Released: 3-Jan-2022 8:55 AM EST
Porous Cellulose-Collagen Scaffolds For Soft Tissue Regeneration: Influence of Cellulose Derivatives On Mechanical Properties And Compatibility With Adipose-Derived Stem Cells.
Preprints

Katarína Kacvinská, Martina Trávničková, Lucy Vojtová, Petr Poláček, Jana Dorazilová, Martin Kohoutek, Júlia Pajorová, Mária Tirpáková, Lucie Bačáková

Released: 3-Jan-2022 2:00 AM EST
Histone variant H3. 3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability
Nature Cell Biology

Histone variants and the associated post-translational modifications that govern the stemness of haematopoietic stem cells (HSCs) and differentiation thereof into progenitors (HSPCs) have not been well defined. H3. 3 is a replication-independent …

Released: 3-Jan-2022 2:00 AM EST
Electrospun Polysaccharide Scaffolds: Wound Healing and Stem Cell Differentiation
Journal of Biomaterials Science, Polymer Edition

Irrespective of the labyrinth of fastidiously woven artificial scaffolds, the lack of biocompatibility hampers effective clinical translation, which is the definitive purpose of any biomedical system or device. Hence, the current exploration deals with the …

Released: 3-Jan-2022 2:00 AM EST
Stem Cell-Derived Extracellular Vesicle-Bearing Dermal Filler Ameliorates the Dermis Microenvironment by Supporting CD301b-Expressing Macrophages
ACS Nano

Hyaluronic acid-based hydrogels (Hyal-Gels) have the potential to reduce wrinkles by physically volumizing the skin. However, they have limited ability to stimulate collagen generation, thus warranting repeated treatments to maintain their …

Released: 3-Jan-2022 2:00 AM EST
Late follow‐up of genital and ophthalmologic chronic graft‐versus‐host disease in females after allogeneic stem cell transplantation
Acta Obstetricia et Gynecologica Scandinavica

Introduction Genital chronic graft‐versus‐host disease (cGvHD) is a common late effect after allogeneic stem cell transplantation. In a previous cross‐sectional study, prevalence, signs and symptoms of genital and extra‐genital cGvHD were accounted …

Released: 3-Jan-2022 2:00 AM EST
Metal Phenolic Nanodressing of Porous Polymer Scaffolds for Enhanced Bone Regeneration via Interfacial Gating Growth Factor Release and Stem Cell Differentiation
ACS Applied Materials & Interfaces

Porous polymer scaffolds are essential materials for tissue engineering because they can be easily processed to deliver stem cells or bioactive factors. However, scaffolds made of synthetic polymers normally lack a bioactive cell-material interface and …

Released: 3-Jan-2022 2:00 AM EST
Body Composition Impacts Hematopoietic Stem Cell Transplant Outcomes in Both Autologous and Allogeneic Transplants: A Systematic Review
Nutrition and Cancer

Abstract According to World Health Organization, over 50,000 hematopoietic stem cell transplants (HSCTs) are performed annually worldwide. Though HSCT can extend life-expectancy and improve disease-related health burdens, it is not without …

Released: 3-Jan-2022 2:00 AM EST
Mesenchymal Stem Cell-Derived Exosomes Modulate Chondrocyte Glutamine Metabolism to Alleviate Osteoarthritis Progression
Mediators of Inflammation

Osteoarthritis (OA) had a high incidence in people over 65 years old, and there is currently no drug that could completely cure it. This study is aimed at studying the role of exosomes in regulating glutamine metabolism in the treatment of OA. First, we …

Released: 3-Jan-2022 2:00 AM EST
Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis
Journal of Advanced Research

Introduction Cigarette smoking is the main risk factor for lung cancer. MSCs in the TME promoting tumor angiogenesis, growth, and metastasis. SIBLING proteins enable cancer cells to extend, invade and metastasize. Objectives Cigarette smoke …

Released: 2-Jan-2022 12:00 PM EST
Transplantation of IPSC-Derived Cardiomyocyte Patches for Ischemic Cardiomyopathy
Preprints

Shigeru Miyagawa, Satoshi Kainuma, Takuji Kawamura, Kota Suzuki, Yoshito Ito, Hiroko Iseoka, Emiko Ito, Maki Takeda, Masao Sasai, Noriko Mochizuki-Oda, Tomomi Shimamoto, Yukako Nitta, Hiromi Dohi, Tadashi Watabe, Yasushi Sakata, Koichi Toda, Yoshiki Sawa

Released: 2-Jan-2022 8:55 AM EST
Connexin 43 Gene Ablation Does Not Alter Human Pluripotent Stem Cell Germ Lineage Specification
Biomolecules

Regenerative medicine aims to replace damaged tissues by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. Due to their capacity to produce unlimited numbers of cells of a given cell type, pluripotent stem cells …

Released: 2-Jan-2022 8:55 AM EST
Expression of Snail, Insulin-like mRNA-binding Protein3 (IMP3) and Aldehyde Dehydrogenase 1 (ALDH1) as Diagnostic Markers in Clear Cell, Papillary and Chromophobe Variants of Renal Cell Carcinoma
Middle East Journal of Cancer

… Aldehyde dehydrogenase 1(ALDH1) is a stem cell marker, expressed in many different solid tumors of bladder, pancreas, colon, and kidney. … This stem cell marker is expressed in a number of different solid tumors of bladder,13 pancreas,14 …

Released: 2-Jan-2022 8:55 AM EST
Expression of recombinant Stem Cell Factor fused with Leucine Zipper
The Scientific Journal of Iranian Blood Transfusion Organization

Materials and Methods This experimental study consists of designing a recombinant protein by bioinformatic softwares and the laboratory part of the study. The indices of interest for designing of the protein structures were analysed by various softwares …

Released: 2-Jan-2022 8:55 AM EST
First Successful Kidney Transplantation After Hematopoeitic Stem Cell Transplantation in Malaysia
Transplantation Proceedings

Promising outcomes of kidney transplantation following hematopoeitic stem cell transplantation has been reported. Data from some centers have demonstrated stable graft function without long term immunosuppression. We present our …

Released: 2-Jan-2022 8:55 AM EST
Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening
Clinical and Translational Medicine

Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene‐edited human‐induced pluripotent stem cell‐ derived cardiomyocytes and preclinical drug screening-El‐Battrawy-2021-Clinical …

Released: 2-Jan-2022 8:55 AM EST
Late Endocrine Effects after Stem Cell Transplant in a Young Girl with Griscelli Syndrome
Case Reports in Pediatrics

Background. Griscelli syndrome (GS) is a rare disorder characterized by partial albinism and silver hair with alteration in genes necessary for melanin transport. Type 2 GS is fatal due to severe immunodeficiency without curative stem cell  …

Released: 2-Jan-2022 8:55 AM EST
Evaluation of the Clinical Efficacy of Stem Cell Transplantation in the Treatment of Spinal Cord Injury: A Systematic Review and Meta-analysis
Cell Transplantation

Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19 …

Released: 2-Jan-2022 8:55 AM EST
Nanotopography Sequentially Mediates Human Mesenchymal Stem Cell-Derived Small Extracellular Vesicles for Enhancing Osteogenesis
ACS Nano

Since the first patients received autologous hematopoietic stem cell transplantation (auto-HSCT) more than 60 years ago, therapeutic developments in the field have been substantial. Mobilized peripheral blood cells has replaced bone marrow as …

Released: 2-Jan-2022 8:55 AM EST
miR-671-5p Inhibition by MSI1 Promotes Glioblastoma Tumorigenesis via Radioresistance, Tumor Motility and Cancer Stem-like Cell Properties
Biomedicines

… We previously demonstrated that the cancer stem cell marker Musashi-1 (MSI1) is an RNA binding protein that promotes radioresistance … In addition, miR-671-5p could attenuate tumor migration and cancer stem cell (CSC) characteristics by …

Released: 2-Jan-2022 8:55 AM EST
Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2021
Internal Medicine Journal

Antifungal prophylaxis can reduce morbidity and mortality from invasive fungal disease (IFD). However, its use needs to be optimised and appropriately targeted to patients at highest risk to derive the most benefit. In addition to established risks for …

Released: 2-Jan-2022 8:55 AM EST
Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation
Cells

Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically …

Released: 2-Jan-2022 8:55 AM EST
Allogeneic Stem Cell Transplantation in Multiple Myeloma
Cancers

Simple Summary Due to its graft-versus-myeloma effect, allogeneic hematopoietic stem cell transplantation (allo-SCT) can enable long-term survival or even cure in carefully selected patients with multiple myeloma (MM), but remains controversial …



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