Feature Channels: Stem Cells

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Released: 1-Sep-2022 5:00 AM EDT
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells
Cell Stem Cell

In this issue of Cell Stem Cell, Pham et al. report that naive human pluripotent stem cells can be differentiated into extraembryonic mesoderm cells (EXMCs). EXMCs are maintained for up to 70 days, resemble human and monkey extraembryonic mesoderm,

Released: 1-Sep-2022 5:00 AM EDT
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates
Cell Stem Cell

Muscle stem cells (MuSCs) exhibit different metabolic profiles depending on their activity, however the mechanisms by which mitochondria affect MuSC fate has been understudied. In this issue of Cell Stem Cell, Hong et al. (2022) and Baker et al. (2

Released: 1-Sep-2022 5:00 AM EDT
Uncovering the origins and lineage markers of human heart fields
Cell Stem Cell

In this issue of Cell Stem Cell, Yang et al. devise a protocol for induction and differentiation of human heart-field precursors, drawing on inspiration from in vivo development. Intricate computational analyses uncovered conserved factors governin

Released: 29-Aug-2022 12:00 PM EDT
Genetic contribution to microglial activation in schizophrenia
Preprints

Jari Koistinaho, Marja Koskuvi, Elina Pörsti, Ying Chieh Wu, Kalevi Trontti, Amanda McQuade, Ilkka Ojansuu, Tyrone Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta,

Released: 29-Aug-2022 12:00 PM EDT
ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells
Preprints

Beatriz Parejo-Alonso, Alba Royo-Garcia, Pilar Espiau-Romera, Sarah Courtois, Alvaro Curiel-Garcia, Sladjana Zagorac, Isabel Villaoslada, Kenneth P. Olive, Christopher Heeschen, Patricia Sancho

Released: 29-Aug-2022 12:00 PM EDT
hBMSC-derived Exosomes Mitigate Th17/Treg Homeostasis in Periodontitis via miR-1246
Preprints

Yuxing Xia, Tianfan Cheng, Min Zhou, Feiwu Kang, Chongshan Liao

Released: 29-Aug-2022 12:00 PM EDT
Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium
Preprints

Anna Shirazyan, Haeyoung Park, Ariell M Joiner, Justine Ra, Melissa S Kim, Archana Kumari, Nicole E Franks, Tien Peng, Robert M Bradley, Charlotte M Mistretta, Andrzej A Dlugosz, Benjamin L Allen

Released: 29-Aug-2022 12:00 PM EDT
BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription
Preprints

Wenbo Jia, Liang Yu, Bin Xu, Yanzhi Feng, Jinyi Wang, Jian Chu, Deming Zhu, Chao Xu, Yongping Zhou, Lianbao Kong, Wenzhou Ding

Released: 29-Aug-2022 12:00 PM EDT
Cancer stem-like cells of nasopharyngeal carcinoma express CXCR4 and display highly invasive activity
Preprints

Zhenwei Zhu, Jingyu Li, Jingxian Liu, Yuan He, Yan Xue, Xiangchan Hong, Zeying Jiang, Dangu Luo, Pei Guo, Kaitai Yao, Lin Chen

Released: 29-Aug-2022 12:00 PM EDT
Risk factors of primary poor graft function after allogeneic hematopoietic stem cell transplantation in patients with myeloid tumors
Preprints

Lin-Yi Zhang, Yi-Ying Xiong, Ming-Yan Liao, Xiao Qing, Xiao-Qiong Tang, Luo Xiao-Hua, Hong-Bin Zhang, Wang Li, Liu Lin

Released: 27-Aug-2022 12:00 PM EDT
SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation
Preprints

Michael D Moore, Errin Johnson, Chloe Jacklin, Stephen Johnson, Owen Green, William S James

Released: 26-Aug-2022 12:00 PM EDT
SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells
Preprints

Rene Yu-Hong Cheng, Joseph de Rutte, Andee R Ott, Lucienne Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G James

Released: 26-Aug-2022 12:00 PM EDT
Pancreatic transplant surgery and stem cell therapy: Finding the balance between therapeutic advances and ethical principles
World Journal of Stem Cells

The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering treatments, often characterized by high complexity from a sur

Released: 26-Aug-2022 12:00 PM EDT
HepaCAM Suppresses Glioblastoma Stem Cell Invasion in the Brain
Preprints

Arpan De, John M Lattier, John E Morales, Jack R Kelly, Xiaofeng Zheng, Zhihua Chen, Sumod Sebastian, Jason T Huse, Frederick F Lang, Joseph H McCarty

Released: 26-Aug-2022 12:00 PM EDT
Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfaces
World Journal of Stem Cells

BACKGROUNDThe therapeutic potential of mesenchymal stem cells (MSCs) in the form of three-dimensional spheroids has been extensively demonstrated. The underlying mechanisms for the altered cellular behavior of spheroids have also been investiga

Released: 26-Aug-2022 12:00 PM EDT
Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance
World Journal of Stem Cells

BACKGROUNDImmature dendritic cells (imDCs) play an important role in the induction of donor-specific transplant immunotolerance. However, these cells have limitations, such as rapid maturation and a short lifespan in vivo. In previous studies,

Released: 26-Aug-2022 12:00 PM EDT
Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation
Preprints

Jongmin J Kim, Emma R Steinson, Mei Sheng Lau, David C Page, Robert E Kingston



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