Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer’s, Huntington's disease and spinal cord injuries.
Researchers at UC San Diego have received a $25.6 million grant from the National Institutes of Health and National Institute on Aging to continue the Study of Latinos-Investigation of Neurocognitive Aging, a 12-year assessment of cognitive and brain aging and impairment among aging Latinos.
Harrington Discovery Institute at University Hospitals and the Alzheimer's Drug Discovery Foundation (ADDF) announce a joint request for proposals for the 2022 ADDF-Harrington Scholar Award. The ADDF-Harrington Scholar Award is designed to accelerate the translation of innovative research that could treat, prevent, or slow Alzheimer's disease or related dementias. The Request for Proposal (RFP) is open to academic investigators at accredited medical centers, research institutions, and universities in the United States, Canada, and the United Kingdom. Researchers working on drug development programs that are relevant to, but not presently focused on, the Alzheimer’s field are also encouraged to apply. This award provides a combination of financial support and expert drug development guidance to provide the best chance to move research beyond the bench to the bedside.
In recent years Alzheimer’s disease has been on the rise throughout the world and is rarely diagnosed at an early stage when it can still be effectively controlled.
Medicare costs around the time of a dementia diagnosis are much lower for older adults screened proactively rather than those diagnosed while experiencing a health issue.
A decade-long effort to reduce medication risks for nursing home residents with dementia has paid off in some ways – but produced unintended consequences that now need addressing, new research shows.
New research shows that comorbidities such as chronic kidney disease are associated with higher plasma p-tau levels.
Seven healthy habits and lifestyle factors may play a role in lowering the risk of dementia in people with the highest genetic risk, according to research published in the May 25, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.
UCLA scientists have discovered how the brain links memories and a way to restore this function in aging mice--as well as an FDA-approved drug that achieves the same thing. The Nature findings suggest a new method for combatting middle-aged memory loss.
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Breakthrough COVID-19 cases resulting in infections, hospitalizations and deaths are significantly more likely in cancer and Alzheimer’s patients, according to two new studies from researchers at the Case Western Reserve University School of Medicine.
Adding cranberries to your diet could help improve memory and brain function, and lower ‘bad’ cholesterol – according to new research from the University of East Anglia (UK).
Which vascular risk factors are associated with the risk of developing dementia may vary with age. A new study shows that among people around age 55, the risk of developing dementia over the next 10 years was increased in those with diabetes and high blood pressure. For people around 65 years old, the risk was higher in those with heart disease, and for those in their 70s, diabetes and stroke. For 80-year-olds, the risk of developing dementia was increased in those with diabetes and a history of stroke, while taking blood pressure medications decreased the risk. The study is published in the May 18, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Here are some of the latest articles added to the Behavioral Science channel on Newswise.
Background: Digital health interventions could help to prevent age-related diseases, but little is known about how older adults engage with such interventions, especially in the long term, or whether engagement is associated with cha...
Subjective memory disorders in conjunction with conspicuous levels of beta-amyloid proteins in the cerebrospinal fluid are a strong indication of developing Alzheimer’s disease.
People who have been hospitalized for a major traumatic brain injury (TBI) may have a higher risk of developing dementia when compared to people who do not have a TBI, according to a new study published in the May 11, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A suite of complimentary tests can quantify changes in dogs suspected of suffering from cognitive decline. The approach could benefit dogs and serve as a model for evaluating cognitive decline progression in – and treatments for – humans with Alzheimer’s disease.
Background: Digital health interventions could help to prevent age-related diseases, but little is known about how older adults engage with such interventions, especially in the long term, or whether engagement is associated with cha...
It’s often said that a little stress can be good for you. Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia.
Cedars-Sinai geriatrics experts will present their latest advances in research and care in person at the annual scientific meeting of the American Geriatrics Society (AGS) in Orlando May 12-14, sharing innovations to improve both the quality of patient care and quality of life for older adults.
People with higher levels of antioxidants in their blood may be less likely to develop dementia, according to a study published in the May 4, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A new nationally representative study published online in the Journal of Alzheimer’s Disease Reports found hearing impairment and vision impairment to be independently associated with cognitive impairment.
Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.
妙佑医疗国际(Mayo Clinic) 研究人员提出了一种新的计算模型，用于在阿尔茨海默病症状与脑解剖结构之间建立起映射关系。该模型是通过将机器学习技术应用于患者大脑成像数据而开发的。这个模型利用大脑的完整功能，而不是特定的大脑区域或网络来解释脑解剖结构与心理过程之间的关系。研究结果已发表在《自然通讯》杂志上。
مدينة روتشستر، ولاية مينيسوتا- اقترح باحثو مايو كلينك نموذجًا جديدًا لرسم خرائط أعراض داء الزهايمر في تشريح الدماغ. وتم تطوير هذا النموذج عبر إجراء التعلم الآلي على بيانات تصوير دماغ المرضى، حيث يستخدم الوظيفة الكاملة للدماغ بدلًا من استخدام مناطق أو شبكات دماغية محددة لشرح العلاقة بين تشريح الدماغ ومعالجة الدماغ للعمليات. وتم نشر النتائج في نيتشر كوميونيكيشنز.
Pesquisadores da Mayo Clinic propuseram um novo modelo para mapear os sintomas da doença de Alzheimer na anatomia do cérebro. Esse modelo foi desenvolvido aplicando o processo de aprendizagem de uma máquina a dados de imagens de cérebros de pacientes.
Los investigadores de Mayo Clinic propusieron un nuevo modelo para hacer un mapa de los síntomas de la enfermedad de Alzheimer en la anatomía cerebral. El modelo se creó mediante la aplicación de aprendizaje automático a los datos de imágenes cerebrales de los pacientes.
This research in mice provides evidence for how dynamics in the default mode network of the brain are altered by activating the locus coeruleus region – a small nucleus in the brainstem that releases norepinephrine. It also suggests new targets for treatment to restore DMN function.
UC San Diego researchers developed a smartphone app that could allow people to screen for Alzheimer's disease, ADHD and other neurological diseases and disorders—by recording closeups of their eye. The app uses a smartphone's built-in near-infrared camera and selfie camera to track how a person's pupil changes in size. These pupil measurements could be used to assess a person's cognitive condition.
Scientists have assessed the long-term effects of intranasal insulin on cognition and on gait in people with and without type 2 diabetes mellitus.
Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain. The scientists say this discovery in mice of a new function by cells known as astrocytes opens a whole new direction for neuroscience research that might one day lead to treatments for many disorders ranging from epilepsy to Alzheimer’s to traumatic brain injury.
New research from NUI Galway and Boston University has identified a blood biomarker that could help identify people with the earliest signs of dementia, even before the onset of symptoms.
Background: The dementia epidemic is progressing fast. As the world’s older population keeps skyrocketing, the traditional incompetent, time-consuming, and laborious interventions are becoming increasingly insufficient to address d...
New data shows that the symptoms suffered by people with advanced Alzheimer’s disease and related dementias who live in the community occur at a strikingly similar rate to those of dementia patients in a nursing home.
Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology. The researchers revealed a new way that nature can inhibit or switch off important proteins known as intramembrane proteases — pronounced “pro tea aces” — which the team reported April 26th in the journal eLife.
Tapping into positive emotions and social connections may be key to motivating older adults to exercise. DePaul University psychology professor Joseph Mikels has been awarded a $2.6 million grant from the National Institutes of Health to continue his work on emotion, aging and decision-making throughout the life span.
Feelings of anxiety and depression are common in people living with dementia and mild cognitive impairment, but the best way to treat these symptoms is currently unknown, as medicines often used to treat these symptoms may not be effective for people with dementia and may cause side effects.
Diagnosing Alzheimer's disease can be a complex and time-consuming process, requiring evaluations ranging from brain scans to cognitive and lab tests to reviews of medical history and symptoms. Simpler and faster ways to diagnose the disease are urgently needed. Researchers at Albert Einstein College of Medicine have been awarded a five-year, $4.2 million National Institutes of Health (NIH) grant to detect behavioral markers for Alzheimer’s that are present early in the course of the disease, before it can be clinically diagnosed. Results could help scientists identify people at risk for Alzheimer’s and related problems, such as falls, and lead to new preventive strategies.
A study is the first to examine if sex significantly affects cognitive outcomes in people who follow individually-tailored, multi-domain clinical interventions. The study also determined whether change in risk of developing cardiovascular disease (CVD) and Alzheimer’s disease (AD), along with blood markers of AD risk, also were affected by sex. Results showed that while care in an Alzheimer's Prevention Clinic setting is equally effective at improving cognitive function in both women and men, the personally-tailored interventions used by the researchers led to greater improvements in women compared to men across AD and CVD disease risk scales, as well blood biomarkers of risk such as blood sugar, LDL cholesterol, and the diabetes test HbA1C. Findings are important because women are disproportionately affected by AD and population-attributable risk models suggest that managing risk factors can prevent up to one-third of dementia cases.
Three of four blood tests used to identify people in early stages of Alzheimer’s disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis. Such differences may put Black patients at risk of misdiagnosis.
Alzheimer’s disease is marked by a loss of functional neurons in the brain.
Inside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer’s disease, these errors — known as somatic mutations — may build up at a faster rate.
Cardiovascular disease risk factors, like high blood pressure, diabetes, obesity and smoking, are believed to play key roles in the likelihood of developing cognitive decline, dementia, and Alzheimer’s disease. A new study suggests that people who accumulate these risk factors over time, at a faster pace, have an increased risk of developing Alzheimer’s disease dementia or vascular dementia, compared to people whose risk factors remain stable throughout life. The research is published in the April 20, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
To help address the rising tide of Alzheimer’s disease nationwide, researchers at Albert Einstein College of Medicine in collaboration with faculty at Pennsylvania State University and other institutions, have received a five-year, $32 million grant from the National Institutes of Health (NIH) to support the ongoing Einstein Aging Study (EAS), which focuses on both normal aging and the special challenges of Alzheimer’s disease, and other dementias. EAS was established at Einstein in 1980 and has been continuously funded by the NIH.
Alzheimer’s disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities.
Study examined nearly 10,500 patients hospitalized with COVID-19 pneumonia
A test of protein in the blood gets further support as a biomarker for patients diagnosed with frontotemporal dementia (FTD), a group of brain disorders with few treatment options. These disorders are characterized by changes in behavior, cognition, language or movement.
A new study from Case Western Reserve University suggests a key protein molecule plays a major role in the accumulation of brain cholesterol, triggering the development of Alzheimer’s and supporting the use of peptide inhibitors as a therapeutic treatment target. The study found that mice, when treated with the peptide inhibitor, demonstrated 50% restored memory function, based on testing such as navigating mazes.
A new study discloses that firearm retailers and law enforcement agencies support providing firearm storage to their community.
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