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Medicine

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Retinitis Pigmentosa, Vision Loss, Stem Cells, California Institute For Regenerative Medicine, retinal progenitor cells

jCyte Presents Results of Clinical Testing in Retinitis Pigmentosa

In a phase 1/2a study jCyte's investigational therapy, jCell, showed a good safety profile and indications of potential benefit for patients with retinitis pigmentosa

Medicine

Science

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muscle stem cells, skeletal muscle, Muscular Diseases, Muscular dystrophies, Aging, tissue damage, MUSCLE ATROPHY

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 14-Dec-2017 4:00 PM EST

Science

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Stem Cells, Cancer, Biochemistry & Biophysics, Pharmacology

What Keeps Stem Cells in Their Undifferentiated State?

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A special cluster of proteins helps unwind DNA during cell division and plays a key role in keeping stem cells in their immature state. This UNC study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death.

Medicine

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Lymphoma treatment, Lymphoma

Combination Immunotherapy Shown to Be Effective Initial Treatment for Relapsed or Refractory Hodgkin Lymphoma

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For many people with classical Hodgkin lymphoma, the disease is one of the most curable forms of cancer with standard chemotherapy or chemo plus radiotherapy. But for the 10 to 30 percent of patients whose cancer relapses, or doesn’t respond to initial therapy, secondary treatment often involves harsher chemotherapies followed by an autologous stem cell transplant, which uses a patient’s own stem cells.

Medicine

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Disparities, Stem Cell Therapy, Multiple Myeloma

Study Identifies Barriers to Transplant Therapy to Treat Multiple Myeloma Among Racial Minority Groups

A study by researchers at Mayo Clinic’s campus in Jacksonville, Florida has found that barriers to patients receiving stem cell therapy as part of their treatment for multiple myeloma include income, education, insurance status and access to care at an academic center or facility that treats a high volume of patients.

Medicine

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Cancer, Breast Cancer, Cell Biology, Metastatic Disease

Drug Suppresses Spread of Breast Cancer Caused by Stem-Like Cells

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Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Science

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multiple myelmoma, Cancer, Hematologic Cancers

Study Explores Use of Checkpoint Inhibitors After Relapse From Donor Stem Cell Transplant for Hematologic Cancers

Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such agent – nivolumab – indicate that along with signs of effectiveness, it also produced significant side effects at the dose initially studied. The findings indicate a need for further clinical trials in this group before being considered for off-label use with these patients, Dana-Farber Cancer Institute investigators report.

Medicine

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Cancer, Hematology, stem cell tranplantation, Graft Versus Host Disease, Immunotherapy

Immunotherapy Drug for Rheumatoid Arthritis Nearly Eliminates Severe Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplant

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Results from a phase 2 clinical trial, presented by Seattle Children’s Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

Medicine

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Children's Hospital Los Angeles, Leukemia, Stem Cell Transplant, Donor, Acute Myeloid Leukemia, be the match, National Marrow Donor Program, Chemotherapy, Stem Cells, Cancer

#FiercePierce: 2-Year-Old Patient Beats Back Leukemia and Inspires Thousands of Potential Stem Cell Donors

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2-year-old Children's Hospital Los Angeles patient Pierce Kelly beats leukemia thanks to a stem cell donor in France and inspires thousands of potential donors.

Medicine

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Cancer, Multiple Myeloma, hematologic, Genetics, Stem Cell, Regenerative Medicine, Cancer Stem Cells, Molecular Biology, Cell Biology, Pharmaceutical Science

In Multiple Myeloma, High Levels of Enzyme ADAR1 are Associated with Reduced Survival

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Using a database of multiple myeloma patient samples and information, researchers at University of California San Diego School of Medicine found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells.







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