Stem Cells Research News and Press Releases

Released: 20-Sep-2022 11:05 AM EDT

Anti-sedative could alleviate cancer therapy side effects, study suggests

Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.

Research Results MEDICINE

Released: 19-Sep-2022 12:00 PM EDT

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Anti-sedative could alleviate cancer therapy side effects, study suggests

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system

Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming

Weight Loss Post Allogeneic Stem Cell Transplant is Associated with Increased Transplant Related Mortality

Differential expression of KAT6A in amyotrophic lateral sclerosis.

Differential expression of APOC1 in amyotrophic lateral sclerosis.

Within-host virus evolution during the extended treatment of RSV infection with mutagenic drugs

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Differential expression of LINC00908 in amyotrophic lateral sclerosis.

Differential expression of SNX29P1 in amyotrophic lateral sclerosis.

Differential expression of LOC100507477 in amyotrophic lateral sclerosis.

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

The downstream PPARγ target LRRC1 participates in early-stage adipocytic differentiation

NOTCH-pathway inactivation reprograms oral-stem-like cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality

Clinicopathological correlation of p40/TTF1 co-expression in NSCLC and review of related literature

Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function

What are Factors Influencing on Life Space Mobility in Cancer Survivors after Hematopoietic Stem CellTransplantation? -Physical and Psychological Function, Physical Symptoms, Environment, or Employment Status?

What do the Transcriptome and Proteome of Menstrual Blood-derived Mesenchymal Stem Cells Tell us about Endometriosis?

The blood stem cell research that could change medicine of the future

Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes

A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor, and donor lymphocyte infusion for relapsed acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue

X-linked adrenoleukodystrophy patient fibroblast-iPSC-derived astrocytes reveal phenotype-specific metabolic, inflammatory, and microRNA alterations

Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells

Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators

Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway

Macromolecular crowding facilitates rapid fabrication of intact, robust cell sheets

Unselfish traits and social decision-making patterns characterize six populations of real-world extraordinary altruists

Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy

Impact of pretransplant donor-specific anti-HLA antibodies in HLA-mismatched peripheral blood stem cell transplantation

Placental mesenchymal stem cells ameliorate NLRP3 inflammasome induced ovarian insufficiency by modulating macrophage M2 polarization

Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics

Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages

p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation

Identification of the Metaphyseal Skeletal Stem Cell

A time and single-cell resolved model of hematopoiesis

How can you explain the pain? Get the latest research on pain management in the Pain channel

Surprising discovery by UCI-led team links Piezo1 and cholesterol during brain development

Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor, a candidate mediator of hearing restoration mechanisms.

ESDR579 - Clinical grade human pluripotent stem cells derived engineered skin substitutes promote keratinocytes wound closure in vitro

3D Human Induced Pluripotent Stem Cell-derived Bioengineered Skeletal Muscles for Tissue, Disease and Therapy Modelling

ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation

Photoelectrochemical imaging of action potentials for single cardiomyocytes through contact force manipulation of organoids

Elevation of cAMP upregulates Cav1.2 expression and promotes odontogenic differentiation of dental pulp stem cells

CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development

Stem Cell-Gene Therapy Shows Promise in ALS Safety Trial

Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion

Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer

A Beefy-R culture medium: replacing albumin with rapeseed protein isolates

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition

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Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP₇ metabolism in enteric nervous system