Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
PreprintsChuanying Geng, Huixing Zhou, Huijuan Wang, Yanchen Li, Yun Leng, Zhiyao Zhang, Yuan Jian, Guangzhong Yang, Wenming Chen
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Released: 5-Oct-2022 12:00 PM EDT
Released: 5-Oct-2022 12:00 PM EDT
Inflammation drives age-induced loss of tissue resident macrophages
PreprintsKémy Adé, Javier Saenz Coronilla, Dorian Obino, Tobias Weinberger, Caroline Kaiser, Sebastien Mella, Cheng Chen, Lida Katsimpardi, Catherine Werts, Pascal Dardenne, Yvan Lallemand, Elisa Gomez-Perdiguero
Released: 5-Oct-2022 5:05 AM EDT
Bright genetics: directed mutations increased the stability of proteins-lights
Scientific Project LomonosovRussian scientists acquired stable and bright fluorescent protein moxSAASoti, which can change color and intensity of its fluorescence. To achieve this aim, the scientists made point changes in the sequence of the coding gene.
Released: 4-Oct-2022 2:05 PM EDT
Tissue chip developments: what’s the 411?
National Institute of Biomedical Imaging and BioengineeringNIBIB-funded researchers have developed an interlinked tissue chip system that can model four mature organs in their perspective environments simultaneously. These multi-organ tissue chips could represent a new way to evaluate diseases or drugs that affect multiple different tissues.
Released: 4-Oct-2022 12:00 PM EDT
Single cell transcriptomics of human prenatal anterior foregut-derived organs identifies distinct developmental signatures directing commitment and specialization of the thymic epithelial stroma
PreprintsAbdulvasey Mohammed, Priscila Ferreira Slepicka, Benjamin Solomon, Kelsea M Hubka, Michael G Chavez, Christine Y Yeh, Virginia D Winn, Casey A Gifford, Purvesh Khatri, Andrew Gentles, Katja Gabrielle Weinacht
Released: 4-Oct-2022 12:00 PM EDT
In vivo generation of heart and vascular system by blastocyst complementation
PreprintsGiulia Coppiello, Paula Barlabe, Marta Moya-Jodar, Gloria Abizanda, Carolina Barreda, Elena Iglesias, Javier Linares, Estibaliz Arellano-Viera, Adrian Ruiz-Villalba, Eduardo Larequi, Xonia Carvajal-Vergara, Beatriz Pelacho, Felipe Prosper, Xabier L. Arangur
Released: 4-Oct-2022 12:00 PM EDT
Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.
PreprintsPaolo Petazzi, Telma Ventura, Alisha May, Francesca Paola Luongo, Helen Alice Taylor, Nicola Romanò, Lesley Margaret Forrester, Pablo Menéndez, Antonella Fidanza
Released: 4-Oct-2022 12:00 PM EDT
Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis
PreprintsShuang Lai, Li Deng, Cong Liu, Xinlun Li, Liyuan Fan, Yushu Zhu, Yiling Yang, Yandong Mu
Released: 3-Oct-2022 12:00 PM EDT
Establishment of a human pluripotent stem cell-derived MKX-tdTomato reporter system
PreprintsYuki Fujisawa, Ming Lu, Daisuke Yamada, Tomoka Takao, Takeshi Takarada
Released: 3-Oct-2022 12:00 PM EDT
Integrative Cut&Tag/RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human iPSCs reprogramming
PreprintsNiccolo Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Rehakova, Oriana Lo Re, Irena Koutna, Tommaso Mazza, Manlio Vinciguerra
Released: 3-Oct-2022 12:00 PM EDT
SARS-CoV-2 spike protein induces endothelial dysfunction in 3D engineered vascular networks
PreprintsBrett Stern, Peter Monteleone, Janet Zoldan
Released: 3-Oct-2022 11:05 AM EDT
ABRF 2023 Research Group Studies
Association of Biomolecular Resource Facilities (ABRF)The Association of Biomolecular Resource Facilities (ABRF) Executive Board is pleased to announce the approval of several innovative studies to be conducted by ABRF Research Groups in 2023, to address ongoing questions in biomolecular research techniques and methods.
Released: 3-Oct-2022 11:05 AM EDT
US has capacity to make essential drugs, study finds
Washington University in St. LouisThe White House has sounded the alarm about vulnerabilities in the pharmaceutical supply chain. But new research from the Center for Analytics and Business Insights at Olin Business School found that the U.S. actually has the capacity to make the nation’s most essential and critical drugs — yet it's mostly sitting idle.
Released: 2-Oct-2022 12:00 PM EDT
Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs
PreprintsSean de la O, Zhe Liu, Sean Chang, Julie B Sneddon
Released: 2-Oct-2022 12:00 PM EDT
Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients
PreprintsHeather A McCauley, Anne Marie Riedman, Jacob R Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A Lang, James M. Wells
Released: 1-Oct-2022 12:00 PM EDT
Estrogens dynamically regulate neurogenesis in the dentate gyrus of adult female rats
PreprintsShunya Yagi, Yanhua Wen, Liisa Galea
Released: 1-Oct-2022 12:00 PM EDT
Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine Osteoarthritis
PreprintsEmily J Clarke, Emily Johnson, Eva Caamano Gutierrez, Camilla Andersen, Lise Berg, Rosalind Jenkins, Casper Lindegaard, Kristina Uvebrant, Evy Lundgren-Akerlund, Agnieszka Turlo, Victoria James, Stine Jacobsen, Mandy J. Peffers
Released: 1-Oct-2022 12:00 PM EDT
Dual states of Bmi1-expressing intestinal stem cells drive epithelial development and tissue regeneration
PreprintsNicholas R. Smith, Sidharth K. Sengupta, Patrick Conley, Nicole R. Giske, Christopher Klocke, Brett S. Walker, Noelle McPhail, John R. Swain, Yeon Jung Yoo, Ashley N. Anderson, Paige S. Davies, Nasim Sanati, Theresa N. Nguyen, Kristo
Released: 28-Sep-2022 12:00 PM EDT
A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells
PreprintsMedeea C Popescu, Naomi L Haddock, Elizabeth B Burgener, Laura S Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul Bollyky, Carlos E Milla
Released: 28-Sep-2022 12:00 PM EDT
A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs
PreprintsWouter H. van der Valk, Edward S.A. van Beelen, Matthew R. Steinhart, Carl Nist-Lund, John C.M.J. de Groot, Peter Paul G. van Benthem, Karl R. Koehler, Heiko Locher
Released: 28-Sep-2022 12:00 PM EDT
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling
PreprintsXing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Müschen, Jungmin Choi, Joao Pedro Pereira
Released: 28-Sep-2022 12:00 PM EDT
The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the skin stem cell transcriptome
PreprintsL. Francisco Lorenzo-Martín, Xosé R Bustelo
Released: 28-Sep-2022 12:00 PM EDT
Royal jelly maintains epidermal stem cell properties by repressing senescence
PreprintsMariko Moriyama, Yuko Miyake, Tomomi Degawa, Nobuaki Okumura, Hiroyuki Moriyama
Released: 28-Sep-2022 12:00 PM EDT
Differential expression of ZFP36L2 in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 28-Sep-2022 12:00 PM EDT
Differential expression of CTSH in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 28-Sep-2022 12:00 PM EDT
Differential expression of DHRS9 in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 28-Sep-2022 8:00 AM EDT
Keeping Current with Landslide Prediction Tools
American Society of Agronomy (ASA), Crop Science Society of America (CSSA), Soil Science Society of America (SSSA)Landslides threaten many lives. A new study suggests we could predict landslides better with electrical measurements of soil.
Released: 27-Sep-2022 1:05 PM EDT
Puzzle Medical Devices Inc. Wins TCT 2022 Shark Tank Innovation Competition
Cardiovascular Research Foundation (CRF)The Cardiovascular Research Foundation (CRF) is pleased to announce that Puzzle Medical Devices Inc. has won the TCT 2022 Shark Tank Innovation Competition for its novel circulatory support device that is implanted percutaneously in the abdominal aorta. The competition took place during Transcatheter Cardiovascular Therapeutics (TCT), the world’s premier educational meeting specializing in interventional cardiovascular medicine, September 16-19 in Boston. The winner was also presented with the Jon DeHaan Foundation Award for Innovation in Cardiology.
Released: 27-Sep-2022 12:00 PM EDT
Retrospective analysis of patients with severe combined immune deficiency: A 20-year Single center experience
PreprintsSevim Busra Korkmaz, Selma Erol Aytekin, Huseyin Tokgoz, Sukru Guner, Ismail Reisli, Sevgi Keles
Released: 27-Sep-2022 12:00 PM EDT
Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency
PreprintsCoral K Wille, Xiaoya Zhang, Spencer Haws, John Denu, Rupa Sridharan
Released: 27-Sep-2022 12:00 PM EDT
Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements
PreprintsArdian Ferraj, Peter A Audano, Parithi Balachandran, Anne Czechanski, Jacob I Flores, Alexander A Radecki, Varun Mosur, David S Gordon, Isha A Walawalkar, Evan E Eichler, Laura G Reinholdt, Christine R Beck
Released: 27-Sep-2022 12:00 PM EDT
Sleep-wake Disturbance following Allogeneic Hematopoietic Stem Cell Transplantation: Trajectory and Correlates
PreprintsMuthu Veeraputhiran, Jennifer Gernat, Naveen Yarlagadda, Milan Bimali, Ellyn E. Matthews
Released: 27-Sep-2022 12:00 PM EDT
Donor cord blood aging accelerates in recipients after transplantation
PreprintsMakoto Onizuka, Tadashi Imanishi, Kaito Harada, Yasuyuki Aoyama, Jun Amaki, Masako Toyosaki, Shinichiro Machida, Eri Kikkawa, Sanetoshi Yamada, Kazuhiko Nakabayashi, Kenichiro Hata, Ken Higashimoto, Hidenobu Soejima, Kiyoshi Ando
Released: 27-Sep-2022 12:00 PM EDT
Olfactory microvillar tuft cells direct neurogenesis during allergic inflammation
PreprintsSaltanat Ualiyeva, Evan R Lemire, Amelia Boyd, Caitlin Wong, Evelyn C Aviles, Alice Maxfield, Rachel Roditi, Nora Barett, Kathleen M Bucheit, Tanya M Laidlaw, Joshua A Boyce, Lora G Bankova, Adam L Haber
Released: 27-Sep-2022 12:00 PM EDT
ESDR336 - Induced pluripotent stem cell-derived macrophages in an inflammatory skin disease model to study granuloma formation
PreprintsLisa Kleissl, Anna Redl, Teresa Neuwirth, Ruth Dingelmaier-Hovorka, Ram Pandey, Georg Stary
Released: 27-Sep-2022 12:00 PM EDT
Intertwining neuropathogenic impacts of aberrant circadian rhythm and impaired neuroregenerative plasticity in Huntington’s disease: Neurotherapeutic significance of chemogenetics
PreprintsSowbarnika Ravichandran, Ramalingam Suhasini, Sudiksha Madheswaran Deepa, Divya Bharathi Selvaraj, Jemi Feiona Vergil Andrews, Viruthachalam Thiagarajan, Mahesh Kandasamy
Released: 26-Sep-2022 12:00 PM EDT
Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia
World Journal of Stem CellsBACKGROUNDThe effect of hypoxia on mesenchymal stem cells (MSCs) is an emerging topic in MSC biology. Although long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) are reported to play a critical role in regulating the biological character
Released: 26-Sep-2022 12:00 PM EDT
Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells
World Journal of Stem CellsBACKGROUNDRecent studies have demonstrated that mesenchymal stem cells (MSCs) can rescue injured target cells via mitochondrial transfer. However, it has not been fully understood how bone marrow-derived MSCs repair glomeruli in diabetic kidney
Released: 26-Sep-2022 12:00 PM EDT
Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease
World Journal of Stem CellsInflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis and is an idiopathic, chronic inflammatory disease of the colonic mucosa. The occurrence of IBD, causes irreversible damage to the colon and increases the risk o
Released: 26-Sep-2022 12:00 PM EDT
Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells
World Journal of Stem CellsBACKGROUNDHeart diseases are the primary cause of death all over the world. Following myocardial infarction, billions of cells die, resulting in a huge loss of cardiac function. Stem cell-based therapies have appeared as a new area to support h
Released: 26-Sep-2022 12:00 PM EDT
Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction
PreprintsShaojun Xie, Sulbha Choudhari, Chia-Lung Wu, Karen Abramson, David Corcoran, Simon G Gregory, Jyothi M Thimmapuram, Farshid Guilak, Dianne Little
Released: 26-Sep-2022 12:00 PM EDT
Cell cycle dynamics and window of MUTE action during the terminal division of stomata and ramification of its loss-of-function on the cell cycle of an uncommitted precursor
PreprintsDaniel T Zuch, Arvid Herrmann, Eun-Deok Kim, Keiko U Torii
Released: 26-Sep-2022 12:00 PM EDT
ESDR549 - Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia
PreprintsJennifer Gherardini, Allen Annis, Jérémy Chéret, Manuel Aivado, Ralf Paus
Released: 26-Sep-2022 12:00 PM EDT
ESDR382 - Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?
PreprintsJennifer Gherardini, Jérémy Chéret, Maya Collins, Ralf Paus, MaryAnne Senna
Released: 26-Sep-2022 12:00 PM EDT
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes
PreprintsHan Zhu, Gaowei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim, Michael Miller, Georgina Goss, Jenna Kovsky, Austin R Harrington, Diane Saunders, Rebecca Melton, Alvin C Powers, Sebastian Preissl, Francesca M Spagnoli, Kyle J Gaulton,
Released: 25-Sep-2022 12:00 PM EDT
Differential expression of CFTR in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 25-Sep-2022 12:00 PM EDT
Enhancing Sox/Oct cooperativity induces higher-grade developmental reset
PreprintsCaitlin M. MacCarthy, Vikas Malik, Guangming Wu, Taras Velychko, Gal Keshet, Ralf Jauch, Vlad Cojocaru, Hans Scholer, Sergiy Velychko
Released: 25-Sep-2022 12:00 PM EDT
Differential expression of MLX in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 25-Sep-2022 12:00 PM EDT
Differential expression of STC1 in amyotrophic lateral sclerosis.
PreprintsShahan Mamoor
Released: 24-Sep-2022 12:00 PM EDT
LINC01137 facilitate pancreatic cancer stemness via the miR-7155-5p/KLF12/AKT axis
PreprintsKexian Li, Zengyu Feng, Kai Qin, Yang Ma, Shiwei Zhao, Peng Chen, Jiewei Lin, Yongsheng Jiang, Lijie Han, Yizhi Cao, Jiaxin Luo, Minmin Shi, Hao Chen, Jiancheng Wang, Lingxi
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