Feature Channels: Pharmaceuticals

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Pangolins, unique scale-covered mammals, are drastically declining in numbers across Asia and Africa, largely due to illegal trade. Part of the trade, both legal and illegal, supports the traditional Chinese medicine market, which has attracted conservation attention.

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A significant clinical trial under the direction of Michael Kappelman, MD, MPH, professor of pediatrics at UNC School of Medicine, found that patients receiving the tumor necrosis factor inhibitor adalimumab combined with a low dose of methotrexate, a second immunosuppressant, did better than those treated with infliximab alone. Patients who received infliximab, another tumor necrosis factor inhibitor, had similar outcomes with or without methotrexate.

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A pesar de las directrices, el tratamiento de primera línea para el estado epiléptico a menudo es inadecuado. Los estudios sugieren que hasta dos tercios de los pacientes reciben dosis subclínicas de benzodiazepinas, ya sea antes de llegar a un hospital o durante el tratamiento hospitalario de emergencia. ¿Hay soluciones?

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Anticancer drugs are pivotal to cancer treatment, but their toxicity may not always be limited to cancer cells, resulting in harmful side-effects.

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A roundup of the latest medical discoveries and faculty news happening at Cedars-Sinai in March 2023.

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A common anesthesia drug could be beneficial in reducing pressure inside the skull of children with traumatic brain injuries (TBI), according to a study published in Critical Care Medicine.

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Ochsner Health Doctor of Pharmacy discusses Narcan use and availability.

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As the U.S. Supreme Court considers a case involving a cholesterol lowering drug, Sean Tu, a West Virginia University College of Law professor, said he believes pharmaceutical companies manipulate the patent system to maintain monopoly rights.

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The March special issue of SLAS Discovery deviates from its traditional focus on assay technology, disease area or molecular target to introduce and explore protocol articles – the newly accepted article type for outlining detailed scientific methods and procedures.

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A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

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Overdose mortality among people age 65 and older quadrupled over 20 years, suggesting the need for greater mental health and substance use disorder policies addressed at curbing the trend.

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The American Society of Anesthesiologists (ASA) urges the public to help fight the opioid epidemic by learning to recognize and respond to an overdose. This includes understanding how to use naloxone, a life-saving medication approved today for sale over the counter by the U.S. Food and Drug Administration.

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Recordings of media briefings will be posted by 10 a.m. Eastern Time on each day. Watch recorded media briefings at: www.acs.org/ACSSpring2023briefings.

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New research has revealed important information about how aspirin works. The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.

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The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.

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Kristin Rojas, M.D., assistant professor of surgical oncology at Sylvester Comprehensive Cancer Center, has been awarded a three-year, $375,000 grant to investigate the role opioids may play in breast cancer.

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From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.

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A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

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In APL Bioengineering, researchers develop a 3D cell culture system to test how inhibiting fibroblast activities can help treat lung cancer. To simulate the tumor microenvironment and mimic real tissues, the team co-cultured lung cancer cells and fibroblasts in a 3D matrix. The researchers then tested the anti-cancer drug cisplatin with and without two anti-fibrotic drugs, nintedanib and pirfenidone. They found that combining the anti-fibrotic drug nintedanib with the anti-cancer drug cisplatin increased the efficacy of the latter.

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Naloxone can reverse potentially fatal overdoses, but it’s less effective against powerful fentanyl. To develop alternatives, researchers are looking to a component of marijuana, CBD. They will present their results at ACS Spring 2023.

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The American Society of Anesthesiologists (ASA) is extremely pleased that the decision in the lawsuit filed against ASA, the editor-in-chief of Anesthesiology – the official peer-reviewed scientific journal of ASA – and 11 contributing authors by Pacira Biosciences Inc., which was originally dismissed by the United States District Court for the District of New Jersey in 2022, has been affirmed by the United States Court of Appeals for the Third Circuit.

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Researchers at Argonne’s Advanced Photon Source have used serial crystallography, a way to make molecular movies, to see in real time the mechanisms involved in an enzyme that confers antibiotic resistance to a certain bacterium.

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Needles are an uncomfortable but necessary aspect of vaccination. But today, scientists report steps toward an alternative, relatively painless method that can deliver biological materials to cells by “shooting” them in with air. They will present their results at ACS Spring 2023.

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A new study identified a compound that prevents C. diff infection. Researchers are now using this compound to develop new drug candidates that might eventually offer a way to prevent serious C. diff infections.

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Corneal transplants can be the last step to returning clear vision to many patients suffering from eye disease. Each year, approximately 80,000 corneal transplantations take place in the U.S. Worldwide, more than 184,000 corneal transplantation surgeries are performed annually.

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MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver.

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Avinash Sahu, PhD, and his team leveraged artificial intelligence, machine learning, and big data to create a novel way to discover multi-function drugs. The approach used cancer research data, biological data, and transfer learning to not only find drugs with specific properties but also to predict patient responses to them.

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A new study has found that people with epilepsy have an increased risk of early death and the increased risk varies depending on where they live, the number of medications they take and what other diseases they may have. The study is published in the March 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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New research makes the case for why curcumin could help enhance treatment for ovarian cancer.

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University of Wyoming researchers’ study of how microscopic creatures called tardigrades survive extreme conditions has led to a major breakthrough that could eventually make life-saving treatments available to people where refrigeration isn’t possible.

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Staphylococcus aureus, Clostridioides difficile, Candida auris, Drug-resistant Shigella. These bacteria not only have difficult names to pronounce, but they are also difficult to fight off. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antimicrobial resistance is an urgent global public health threat.

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In early March, Eli Lilly made headlines after announcing a new $35 price cap on insulin for individuals with private insurance. Novo Nordisk and Sanofi made their own price reduction announcements shortly after Eli Lilly’s move.

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The combination of two oral medications has shown positive results in people with prostate cancer, whose disease has spread to other parts of the body. Compared with XTANDI plus placebo, the investigatory combination of TALZENNA and XTANDI demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival.

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UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.

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Ochsner Health is leading the way for precision medicine nationwide by becoming one of the first hospital systems to standardize genomic testing, significantly advancing ways in which care teams can treat cancer patients. This change helps providers determine individualized treatment by understanding how patients will react to certain drugs, thereby lowering risk of adverse side effects, improving patient experience, and bettering patient outcomes.