Staphylococcus aureus bacteria are a major cause of serious infections that often persist despite antibiotic treatment, but scientists at the UNC School of Medicine have now discovered a way to make these bacteria much more susceptible to some common antibiotics.
The study is the first to put antibiotic biosynthesis and resistance into an evolutionary context. The findings will help to guide the future discovery of new antibiotics and antibiotic alternatives which are medicines that are vitally needed given the current global threat of antimicrobial resistance.
Resistance to two critical antibiotic types, one a “drug of last resort” when all others fail against some “superbugs,” are widely distributed in Southeast Asia, raising the risk of untreatable infections, say a team of investigators led by Georgetown University Medical Center.
OS-MRSA has created confusion in clinical laboratories for the past decade because of its difficulty to diagnose. Findings of a new study identified a way to detect what an important gene has been hiding that could be critical for the successful treatment of the superbug.
The Centers for Medicare and Medicaid Services Inpatient Prospective Payment System rule for the coming fiscal year will raise reimbursements for novel antibiotics, a meaningful step in confronting the threat of infections resistant to older medicines. At the same time, the rule does not require or support antibiotic stewardship in healthcare settings, also an essential measure to protect the effectiveness of existing infection-fighting medicines.
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health examined independent charity prescription drug assistance programs in the U.S. and found that nearly all—97 percent—did not provide coverage for uninsured patients.
A new study by researchers at Intermountain Healthcare has found that administering broad-spectrum antibiotics, which act against a wide range of disease-causing bacteria, to treat patients with pneumonia often does more harm than good.
Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to draw natural killer immune cells to cancer cells.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
Over one billion people, including 880 million children, are infected with intestinal nematode worms, such as roundworms, hookworms and tapeworms, according to the World Health Organization.
Scientists in recent years have hypothesized that cell-cell differences aides the emergence of drug resistance. A new study published online in Nature Communications has tested this theory and yielded findings that may provide a path to reduce chemotherapy resistance.
New research from Cornell University offers a new pathway for targeting pathogens in the fight against antibiotic resistant bacteria.
Drug-resistant malaria is prevalent in Southeast Asia and may spread. Doctors currently can tell whether powerful malaria drugs will work through or a DNA duplication method that allows for optical detection of a disease’s biomarkers, but it's tough to use in low-resource areas.
The introduction of the Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms -- DISARM -- Act -- by United States Senators Johnny Isakson (R-GA) and Bob Casey (D-PA) Tuesday represents an essential step toward addressing the growing threat of infections that are increasingly resistant to existing treatments. By improving critical Medicare reimbursement for antibiotics and promoting their appropriate use, the legislation has the potential to stabilize the antibiotics market, spur the development of new infection-fighting drugs, and preserve the effectiveness of existing medicines.
Preschool children with community-acquired pneumonia often receive unnecessary tests and treatment at outpatient clinics and emergency departments, according to a nationally representative study led by Todd Florin, MD, MSCE, from Ann & Robert H. Lurie Children’s Hospital of Chicago.
Tuberculosis is the most lethal infectious disease in the world. Researchers at Washington University School of Medicine in St. Louis and Umea University in Sweden have found a compound that can prevent and even reverse antibiotic resistance in TB bacteria.
A study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed a close association between liposarcoma (LPS), a type of cancer that develops from fat cells, and the bromodomain and extraterminal (BET) protein family.
A new study found that 81% of antibiotics prescribed by dentists to prevent infections prior to dental visits are unnecessary.
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