Leading cancer researcher, Alex Huang MD, PhD, has received a $450,000 Basic Science grant from Pediatric Cancer Research Foundation to study targeted approaches for effectively eliminating metastatic osteosarcoma.
The struggle to get enough nutritious food could be far worse than previously understood, according to a new study examining the intersection between hunger and the types of foods found at nearby stores.
University Hospitals (UH) system in Cleveland names the first president for UH Ventures to build business endeavors, seek opportunities, and expand existing programs
Billions of US taxpayer dollars have been invested in Africa over the past 15 years to improve care for millions suffering from the HIV/AIDS epidemic; yet health systems on the continent continue to struggle. What if the investments and lessons learned from HIV could be used to improve care for those with other serious chronic conditions? With this question in mind, researchers from Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, along with investigators and clinicians based in Uganda, borrowed an HIV/AIDS innovation to seek inroads against rheumatic heart disease in sub-Saharan Africa.
Researchers at The Ohio State University and their colleagues have demonstrated how rising temperatures and acidification combine to destabilize different populations of coral microbes—that is, unbalance the natural coral “microbiome."
A new study found that women who took a specially prepared blend of minerals and nutrients for a month saw their 3-mile run times drop by almost a minute. The women who took the supplement also saw improvements in distance covered in 25 minutes on a stationary bike and a third test in which they stepped on and off a bench, according to research from The Ohio State University.
Announcement of the 2018 Harrington Scholar-Innovator Award recipients by the Harrington Discovery Institute at University Hospitals in Cleveland, Ohio.
Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide. The tiny molecule can change how proteins function. But new research featured in Molecular Cell suggests supplementing nitric oxide—NO—is only the first step. Researchers have discovered previously unknown enzymes in the body that convert NO into “stopgap” molecules—SNOs—that then modulate proteins. The newly discovered enzymes help NO have diverse roles in cells. They may also be prime therapeutic targets to treat a range of diseases.
Bowling Green State University Associate Professor of sociology Dr. Karen Guzzo and an Ohio State University researcher analyzed data that establishes a long-term linkage between adolescent reproductive knowledge and attitude and adult contraceptive behavior. The study appears in the January 2018 issue of Maternal and Child Health Journal.
You can quit work commitments if you want – but some of them never really leave you, new research suggests. In a study of 420 employees representing a wide variety of occupations and work settings at three organizations, researchers found that commitments that workers no longer had were still lingering in their minds.
The key to getting people to work together effectively could be giving them the flexibility to choose their collaborators and the comfort of working with established contacts, new research suggests.
Feelings about the frequency of rape or other forms of sexual assault in a neighborhood are significantly tied to women’s—but not men’s—perceptions of its safety, according to new research.
Teens whose mothers used cocaine during pregnancy are more likely to have aggression and attention problems—known predictors of later drug use and sexual risk-taking. With a new three-year, $840,000 grant from the National Institutes of Health (NIH), researchers at Case Western Reserve University now hope to learn how and when these issues may develop differently in boys and girls—and how best to address behavioral problems caused directly and indirectly by in utero cocaine exposure.
Microscopic yeast have been wreaking havoc in hospitals around the world—creeping into catheters, ventilator tubes, and IV lines—and causing deadly invasive infection. One culprit species, Candida auris, is resistant to many antifungals, meaning once a person is infected, there are limited treatment options. But in a recent Antimicrobial Agents and Chemotherapy study, researchers confirmed a new drug compound kills drug-resistant C. auris, both in the laboratory and in a mouse model that mimics human infection.
Walmart was once considered the future of grocery shopping, offering consumers a slew of discounted choices, compared to the competition. Yet, market trends point toward a faster, cheaper, smaller and more streamlined experience. The result: One of the most common shopping experiences in American life is fundamentally changing, according to a new study in the journal Strategy and Leadership.
Researchers from Case Western Reserve University School of Medicine and collaborators have received a five-year, $2.8 million grant from the National Institute on Aging to identify FDA-approved medications that could be repurposed to treat Alzheimer’s disease. The award enables the researchers to develop computer algorithms that search existing drug databases, and to test the most promising drug candidates using patient electronic health records and Alzheimer’s disease mouse models.
Many consumers have found a way to cope with the knowledge that products they like have been made unethically: They simply forget they ever knew it.
“We’re geeks, and we’re motivated.” That’s how Amin Amooie, a doctoral student in earth sciences at The Ohio State University, explained his team’s efforts to build the supercomputer they’ve dubbed “Buckeye Pi.”
A new study from The Ohio State University Wexner Medical Center examines what may cause chronic back pain in runners and the exercises to help prevent it.
Engineers at The Ohio State University are developing technologies that have the potential to economically convert fossil fuels and biomass into useful products including electricity without emitting carbon dioxide to the atmosphere.
Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Structural and Molecular Biology, researchers revealed atomic-level details of the protein that serves as a passageway for calcium across kidney cell membranes.
New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem cells). Published Dec. 27 and conducted largely in genetic models of obese mice, the study shows obesity causes durable and harmful changes to the hematopoietic stem cell compartment – the blood-making factory in our bodies.
Heading into this football season, 67% of Power 5 conference universities employed at least one full-time sports dietitian and had for at least three years. Currently, 72% of those programs employ at least two full-time sports dietitians, a long road from only eight full-time positions in 2004 when Bragg got her start. There has long been an understanding in sports dietetics that by doing a great job to establish the importance of nutrition on performance within a program, you are thereby teaching the next generation of coaches to value fueling as well. An established bit of advice to sports dietitians regarding growth advises ‘the best way to get your next job, is to be great at the one you already have’. The work these four dietitians have done within their respective programs continues to lay the groundwork for more sports dietitians to find their next job and make their mark in collegiate athletics.
A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir of infected immune cells in people infected by HIV, according to new research.
Announcement of $6.5 million gift from Cleveland philanthropists Sara and Chris Connor for integrative health network at University Hospitals in Northeast Ohio. The will enable UH to recruit a core team of physician leaders to treat patients, educate physicians throughout UH and beyond about how to effectively incorporate integrative therapies into their patient care plans, and conduct research.
Fish sense water motion the same way humans sense sound, according to new research out of Case Western Reserve University School of Medicine. Researchers discovered a gene also found in humans helps zebrafish convert water motion into electrical impulses that are sent to the brain for perception. The shared gene allows zebrafish to sense water flow direction, and it also helps cells inside the human ear sense a range of sounds.
For many people, the holidays mean spending time with family and friends who have fully embraced “fake news” – and are happy to share it with you. A researcher at The Ohio State University has some science-based methods for dealing with people who reject the truth.
In a pair of publications, researchers have shown how cells adapt to stressors—like water loss—by reprogramming their internal signaling networks. The studies describe previously unknown mechanisms that cells use to send signals between cellular machinery and avoid cell death. According to the authors, drugs that enhance the adaptation mechanisms could help cells stave off multiple diseases, including type 2 diabetes. The studies were published in Cell Reports and Molecular Cell.
With a three-year $681,343 grant from the U.S. Environmental Protection Agency, a team of Ohio State scientists plans to develop a widely applicable system for assessing watershed health and determining when a crisis is looming.
Squamous cell carcinoma of the tongue, also known as oral tongue cancer, is an aggressive form of cancer that generally affects older people. Patients with the disease often find it difficult to eat, swallow food, or speak. Reasons for its generally poor prognosis include late detection, before pain usually starts and only when physical symptoms such as lesions are present, and a propensity for spreading to other sites in the body. But in a potential harbinger of hope for arriving at an earlier diagnosis and treatment, in a new study published in Oncotarget, a team of researchers from Case Western Reserve University School of Medicine, Cleveland Clinic, and University Hospitals Cleveland Medical Center has found that bacterial diversity and richness, and fungal richness, are significantly reduced in tumor tissue compared to their matched non-tumor tissues. This raises the prospect that certain bacteria and fungi, in sufficient amounts and in possibly interactive ways, may play a pa
Researchers have found genetic explanations for why most mosquitoes in one species favor nectar over blood. This work could one day lead to strategies to prevent mosquito-borne illness.
The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Sciences, researchers showed triple-negative breast cancer cells are highly vulnerable to interferon-β—a potent antimicrobial that also activates the immune system. The new study shows interferon-β impairs breast cancer cells’ ability to migrate and form tumors. The study also suggests interferon-β treatment could improve outcomes for certain breast cancer patients.
Doctors at The Ohio State University Wexner Medical Center are using a procedure called Subchondroplasty to give patients with damaged hips more treatment options and ultimately avoid replacement surgery.
Toledo heart surgeon is first in the U.S. to perform new heart valve replacement surgery. Heart valve disease affects about five million Americans each year.
Researchers from Case Western Reserve University School of Medicine have received two grant awards, in partnership with investigators from other institutions, from the National Institutes of Health to conduct major studies on Alzheimer’s disease, the most common form of memory loss and other forms of dementia in older persons.
One hypothesis for how autism develops is excessive neuron production in the prenatal period, leading to a transient but significant increase in brain size in the first few years of life in about one-quarter of children with the disease. But the precise timing and cause of this overgrowth is poorly understood. Seeking to help solve this mystery, Tony Wynshaw-Boris, MD, PhD, has received two five-year grants totaling more than $5 million from the National Institute of Mental Health of the National Institutes of Health to uncover links between abnormal embryonic brain development and autism.
The oldest ice core ever drilled outside the polar regions may contain ice that formed during the Stone Age—more than 600,000 years ago, long before modern humans appeared.
The grounds of University House, the official residence of the Bowling Green State University president, include a large, manicured lawn. But behind the green lawn is an equally important but less obviously tended space, a short-grass prairie that the University is carefully returning to its native state.
Women exposed to air pollution just prior to conception or during the first month of pregnancy face an increased risk of their children being born with birth defects, such as cleft lip or palate or abnormal hearts.
Mark A. Griswold, PhD, a professor in the Department of Radiology at Case Western Reserve University School of Medicine, has been elected to the National Academy of Inventors 2017 Fellows Program, the highest professional distinction accorded to academic inventors.
For his life’s work, Farouk El-Baz will receive the 2018 Inamori Ethics Prize from the Inamori International Center for Ethics and Excellence at Case Western Reserve University during a ceremony and academic symposium Sept. 13-14.
In an unprecedented occurrence, each of the four football programs participating in the College Football Playoff will feature a sports dietitian (Sports RD) who spent time professionally or scholastically at the University of Alabama. Amy Bragg, Alabama’s Director of Performance Nutrition, has been with the Crimson Tide for eight seasons and has built one of the leading sports nutrition programs in the country.
What if you could look into the brains of potential drug abusers and see what messages would be most likely to persuade them to “just say no?” That’s the ultimate goal of researchers whose new study scanned the brains of people while they watched anti-drug public service announcements (PSAs).
Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called “long non-coding RNAs” or “lncRNAs,” help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair.
As part of a multi-institution Federal Aviation Administration (FAA) study focused on unmanned aerial systems, researchers at The Ohio State University are helping quantify the dangers associated with drones sharing airspace with planes.
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine, are focusing their efforts on adolescent and young adult (AYA) cancer research. More than 50 leaders from top cancer research institutions will gather this Friday, December 8, in Atlanta to identify a strategic plan for combating AYA cancer for the next three to five years.
Researchers report creating a biologically accurate mass-production platform that overcomes major barriers to bioengineering human liver tissues suitable for therapeutic transplant into people.
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