Treatment with a choline kinase inhibitor prompts immune cells to clear away damaged mitochondria, thus reducing NLRP3 inflammasome activation and preventing inflammation.
New study uses single-cell RNA sequencing technology to find a target for treating EoE. Findings also raise questions about the dietary supplement butyrate.
Researchers at the University of Notre Dame have effectively prevented the binding of peanut allergens with IgE to suppress the allergic reaction to peanuts using a first-in-class design of allergen-specific inhibitors.
Five facts about allergies to vaccines, pulled together by two McMaster University physicians.
A new study shows most American allergists now prescribe under-the-tongue allergy tablets for patients to treat certain allergies.
Dietary intake of two fatty acids, omega-3 and omega-6, may have opposite effects on the severity of asthma in children and may also play opposite roles in modifying their response to indoor air pollution, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
A single allergic reaction during pregnancy prompts sexual-development changes in the brains of offspring that last a lifetime, new research suggests. Female rats born to mothers exposed to an allergen during pregnancy acted more characteristically “male” – mounting other female rodents, for instance – and had brains and nervous systems that looked more like those seen in typical male animals.
After one year of wearing a peanut patch as immunotherapy for their peanut allergy, 35 percent of participating children (aged 4 to 11 years) were able to tolerate a significantly higher dose of peanuts before experiencing an allergic reaction, according to results from an international Phase 3 randomized clinical trial published in the Journal of the American Medical Association (JAMA).
A new study shows urban children with poorly controlled asthma, particularly those who are ethnic minorities, suffer academically. Kids who are kept home due to asthma symptoms often aren’t able to do as well in the classroom.
Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin. Routine testing for this gene could improve patient safety and reduce unnecessary avoidance of other antibiotics, they reported in the Journal of Allergy and Clinical Immunology.
A new study finds vitamin D may be protective among asthmatic obese children living in urban environments with high indoor air pollution. The study out of John Hopkins University School of Medicine, funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, was published in The Journal of Allergy and Clinical Immunology: In Practice.
Research indicates that 10 percent of people with tattoos experience some sort of complication; a board-certified dermatologist can help these individuals.
Cleaning your house of allergens that have built up over the winter can help ease spring allergy symptoms.
Nine out of 10 people who believe they’re allergic to the antibiotic either aren’t allergic or have only some intolerance, and eight of 10 people who had an allergic reaction to penicillin 10 or more years ago will now be fine.
UNC School of Medicine researcher Edwin Kim, MD, MS, says the results of a multi-year observational study are encouraging for those suffering from peanut allergies.
UNC School of Medicine researcher Edwin Kim, MD, MS, says the results of a multi-year observational study are encouraging for those suffering from egg allergies.
UNC School of Medicine researcher Scott Commins, MD, PhD, and his team found the red meat allergy-causing alpha-gal – a sugar in nearly all mammal blood except for humans – is found in tick saliva regardless of whether the tick had recently fed on an animal, challenging previous theories.
UNC SOM researchers are available to speak to media covering the conferences or interested in the topics. To schedule an interview contact Carleigh Gabryel at 919-864-0580 or [email protected].
Michigan State University scientists have identified a master control mechanism on mast cells, a type of immune cell, that can prevent the immune system from overreacting in times of stress, potentially limiting, or even stopping allergic reactions from happening.
Sending kids with allergies and asthma off to summer camp takes an extra dose of planning.
The focus for asthma treatment is often stepping up treatment, but clinicians need to know how to step down therapy when symptoms improve.
Older patients with a diagnosis of chronic sinusitis — a disease of the nasal cavity and paranasal sinuses that often persists over many years — have a unique inflammatory signature that may render them less responsive to steroid treatment, according to a new study published by Vanderbilt researchers.
Valentine's Day tips for keeping loved ones with allergies and asthma sneeze and wheeze free
Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes to make them better able to travel via blood vessels to reach the site of infection. Their work appears on January 15 in the journal Immunity.
While more than 32 million individuals in the U.S. have a documented penicillin allergy in their medical record, studies have shown that more 95 percent actually can be treated safely with this class of antibiotics, improving treatment outcomes and reducing the risk of infection with dangerous resistant pathogens such as Clostridium difficile (C. difficile). A review article in the January 15 issue of JAMA recommends best practices for evaluation of reported penicillin allergies and provides clinicians with guidance and tools to help determine appropriate procedures based on the severity of previously reported reactions.
Organ transplant rejection is a major problem in transplantation medicine. Suppressing the immune system to prevent organ rejection, however, opens the door to life-threatening infections. Researchers at the University of Basel's Biozentrum have now discovered a molecular approach preventing rejection of the transplanted graft while simultaneously maintaining the ability to fight against infections.
New research from the University of Chicago shows that healthy infants have intestinal bacteria that prevent the development of food allergies.
Thanks to a five-year, $3.46 million grant from the National Institute of Allergy and Infectious Diseases, Texas Tech University researchers Harvinder Gill and Steve Presley have teamed up to develop a universal flu vaccine.
The American College of Allergy, Asthma and Immunology strongly urges the Weatherford Independent School District to reconsider their decision to use Benadryl in place of epinephrine for allergic reactions.
Research published in Immunity describes a mechanism in a mouse model of asthma that supports the hygiene hypothesis — researchers found that infant mice need a higher exposure to a bacterial endotoxin, compared to adult mice, to avoid developing asthma-like reactions to house dust mites.
Survey data suggest at least 1 in 10 U.S. adults are food allergic and nearly 1 in 5 believe they have a food allergy. Food allergies are expensive and potentially life-threatening conditions.
Adults think they have food allergies whey they don't
Myths about gluten are hard to bust. Intolerance, allergy, sensitivity, hypersensitivity. What is what? Celiac disease is none of these things. It is an autoimmune disorder, where gluten triggers the immune system to attack the gut. It is common, lifelong, and can seriously harm health - but nobody knows for sure what causes it. Now a review in Frontiers in Pediatrics says a common food additive could both cause and trigger these autoimmune attacks, and calls for warnings on food labels pending further tests.
Experts and research on important topics in the healthcare system
A focus on high-risk tuberculosis patients may be the answer to stalled progress in stamping out the illness in the United States.
Eating is a cultural part of our holiday traditions but, for more and more Americans, a simple holiday gathering could lead to a medical emergency with a bite of the wrong food.
Nursing and pharmacy researchers hope to find a replacement for prednisone with fewer and less-severe side effects.
Pinellas County residents and visitors who are susceptible to the respiratory impacts of Florida's red tide -- especially people with asthma and other chronic lung diseases -- now have a new tool that will help them know their risks before they visit area beaches during red tides.
Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother's gut are passed on to the baby and stimulate the baby's immune responses. This transmission is impacted in children born by caesarean section.
Nasal surgery to relieve obstructed breathing can reduce or eliminate chronic headaches in selected patients, reports a paper in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Physicians at Massachusetts Eye and Ear have, for the first time, induced a sense of smell in humans by using electrodes in the nose to stimulate nerves in the olfactory bulb, a structure in the brain where smell information from the nose is processed and sent to deeper regions of brain. Reporting online today in International Forum of Allergy & Rhinology, the research team describes their results, which provide a proof of concept for efforts to develop implant technology to return the sense of smell to those who have lost it.
If you can reduce the overall stress that comes with the holidays, maybe you can also cut down your allergy and asthma symptoms
Rush University Medical Center has opened a center for airway diseases, a comprehensive program to treat people with interrelated chronic conditions such as sinusitis, allergies, asthma and sleep apnea, which affect millions of people. It is the first program of its kind in Illinois.
About a year after receiving daily oral immunotherapy for severe peanut allergy, 67 percent of children in a Phase 3 trial were able to tolerate eating at least two peanuts (600 mg) without an allergic reaction, while 50 percent tolerated eating three to four peanuts (1,000 mg) without symptoms. At the start of the study, all of these children had allergic reactions after ingesting just 1/10 of a peanut (30 mg). These results of an international, randomized, double-blind, placebo-controlled trial conducted at 66 sites, including Ann & Robert H. Lurie Children’s Hospital of Chicago, were published in the New England Journal of Medicine.
Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. Authors of a new study published in the New England Journal of Medicine say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy. The medication, called AR101, is derived from peanut protein.
A new study by researchers of disease transmission in bats has broad implications for understanding hidden connections that can spread diseases between species and lead to large-scale outbreaks.
Chronic use of oral corticosteroids to treat moderate-to-severe asthma flares creates the potential for serious health risks.
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