Feature Channels: Pain

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根据妙佑医疗国际(Mayo Clinic) 最近发表在《美国医学会杂志》(JAMA)上的一篇大型整合分析报告显示，阿片类药物可缓解偏头痛的证据很少，或者说并不充足。而一些较新的疗法和已被确认的偏头痛治疗方案却有中等到高等强度的疼痛缓解证据支持。

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A evidência de que os opioides oferecem alívio da dor causada pela enxaqueca é baixa ou insuficiente, conforme estudo de meta-análise em grande escala da Mayo Clinic, publicado recentemente na revista médica JAMA.

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La evidencia respecto a que los medicamentos opioides alivian el dolor de la migraña es baja e insuficiente, descubre un gran metanálisis de Mayo Clinic, publicado recientemente en JAMA.

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Patients with newly diagnosed multiple sclerosis report several symptoms - pain, fatigue, depression and anxiety - in the first year. A significant number of them experience a cluster of two or more of those symptoms, according to a new study from Michigan Medicine.

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Expert Q&A: Do breakthrough cases mean we will soon need COVID boosters? The extremely contagious Delta variant continues to spread, prompting mask mandates, proof of vaccination, and other measures. Media invited to ask the experts about these and related topics.

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Study suggests that children and young adults are frequently exposed to unsafe opioid prescriptions.

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As students return to school this fall—many in person for the first time in more than a year—choosing the right backpack and wearing it properly can help to alleviate pain. Studies have shown that backpacks exceeding 10% of a child’s body weight may cause not only back pain but also forward-head posture.

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Bioengineers have developed biocompatible self-assembling “piezoelectric wafers,” which can be made rapidly and inexpensively to enable broad use of implantable muscle-powered electromechanical therapies.

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NIH-funded researchers at Carnegie Mellon University have demonstrated the potential of a neuromodulation approach that uses low-intensity ultrasound energy, called transcranial focused ultrasound—or tFUS.

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Researchers from University of Michigan and Washington University in St. Louis receive $33 million in funding to lead a study comparing anesthetic medications

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The research found that photobiomodulation – a form of low-dose light therapy – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.

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The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a newly discovered protein that controls B cell survival, understanding epigenetic changes in malignant peripheral nerve sheath tumors (MPNSTs) and melanoma, identifying a protein that protect genome stability, developing novel cell therapies for COVID-19, a new option for treating neuropathic pain, exosome delivery of CRISPR/Cas9 to pancreatic cancer, discovering how cancer cells tolerate aneuploidy and the role of health disparities in long-term survival of adolescent and young adult patients with Hodgkin lymphoma.

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A severe skin infection in the orbital area (around the eye) may represent an unusual complication of COVID-19, according to a patient report published in The Journal of Craniofacial Surgery. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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妙佑医疗国际正在尝试将再生医学作为多年来的医学难题——椎间盘退行性疾病的一种潜在长期解决方案。世界上有数百万人长期受到由于脊柱经年磨损导致的颈部和背部疼痛的困扰。对于这种常见病痛，目前的治疗通常只能提供暂时的缓解，找到治愈方法是摆在医学研究者面前的一项挑战。

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A Mayo Clinic está buscando a medicina regenerativa como uma solução em potencial a longo prazo para a doença degenerativa do disco que, há anos, não é contemplada pela ciência médica.

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Mayo Clinic estudia la medicina regenerativa como una posible solución a largo plazo para la enfermedad degenerativa de los discos, que ha evadido a la ciencia médica durante años.

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Molly Neinstein took up gymnastics when she was just 7. Within a few years, she was climbing the ranks of competitive gymnastics and seemingly on a fast track to becoming nationally recognized.

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DETROIT – For the past 21 years, Keisha Triplett lived with pain in her left wrist that limited her quality of life. After undergoing total wrist replacement surgery on May 4, 2021 at Henry Ford West Bloomfield Hospital, Triplett is on her way to recovery and a return to a more normal, pain-free life.Also referred to as total wrist arthroplasty, the surgery involves replacing a severe arthritic wrist joint with an artificial joint made of metal and plastic components.

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Charles C. Park, M.D., Ph.D., Director of The Minimally Invasive Brain and Spine Center at Mercy Medical Center in Baltimore, is now utilizing a less invasive, spinal interbody fusion method called OptiLIF®.

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As we look forward to a fall with hopefully one of the most important vaccination uptakes of children in a generation, a new study provides insights to help parents with reducing post-vaccination distress in younger kids.

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Results from two prospective, concurrent, clinical trials demonstrate that a synthetic meniscus implant provides superior relief from post meniscus surgery knee pain when compared to treatment with non-surgical care alone.

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Treatment provides non-opiate alternative that is minimally invasive with emphasis on functional restoration.

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Until relatively recently, opioids were a mainstay of treatment for pain following total hip or knee replacement. Today, a growing body of evidence supports the use of multimodal analgesia – combinations of different techniques and medications to optimize pain management while reducing the use and risks of opioids, according to a paper in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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The first two-level lumbar disc replacement was performed in Metro DC, Maryland, and Virginia on Friday, June 25, 2021, by Spine Surgeon Dr. Christopher Good (Virginia Spine Institute) - ending an around-the-world journey for one patient looking for relief to more than ten years of debilitating back pain and offering hope to many others looking for an option beyond a conventional spinal fusion that limits mobility.

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Researchers expose live lobsters to vaporized cannabis and confirm the crustaceans absorb THC. Whether the psychoactive compound affects behavior remains open question.

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Graduating fellows are, Ashley Kakkanatt, M.D. (Brain Injury); Aakash Thakral, M.D. (Pain Medicine). The 2021 residency graduates are, Mina Gayed, D.O.; Eric Liu, D.O.; Tomas Salazar, M.D.; Mina Shenouda, M.D.

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During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.

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Advanced Artificial Intelligence System Provides Real-Time Analysis of the Knee in Motion for Improved Diagnosis and Treatment Planning

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The American Society of Anesthesiologists (ASA) today announced Heron Therapeutics, a commercial-stage biotechnology company, as an ASA Industry Supporter for the third year, supporting the work of the Society and physician anesthesiologists to reduce reliance on opioids during or following surgical procedures and ensuring that non-opioid alternatives are available to patients.

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Prior studies have investigated alternative approaches to pain reduction in burn injury patients that focus on distraction, such as music, hypnosis, toys, and virtual reality (VR). In a study published today in JAMA Network Open, Henry Xiang, MD, MPH, PhD, MBA, and his research team reported the use of smartphone-based VR games during dressing changes in pediatric patients with burn injuries.

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A computerized brain implant effectively relieves short-term and chronic pain in rodents, a new study finds.

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Medical guidelines help doctors understand the best way to treat health conditions. Surprisingly, many doctors do not adhere to them, and this is a problem, according to a new study. People with lower back pain injury miss 11 more days of work in a year when they only receive treatments for lower back pain that are not recommended by medical guidelines compared to people treated according to guidelines.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen provide better pain control and have fewer adverse effects than codeine, a commonly prescribed opioid, when prescribed after outpatient surgery, according to new research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.201915.

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Surgeons can ease their patients’ pain from common operations without prescribing opioids, and avoid the possibility of starting someone on a path to long-term use, a pair of new studies suggests.

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A pain-management protocol designed by Emese Zsiros, MD, PhD, FACOG, to be reported at the American Society of Clinical Oncology 2021 annual meeting, resulted in a 45% decrease in opioids prescribed to patients undergoing surgery, without significant effect on recovery or satisfaction.

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At the American Society of Clinical Oncology 2021 virtual Annual Meeting, Roswell Park teams will share data and insights on topics ranging from reducing use of opioids to an analysis of trends in response to cancer treatment among patients of different races.

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Clinician researchers at the University of Miami Miller School of Medicine have shown that patients don’t necessarily need opioids for pain relief following robotic prostatectomies. In a study published in the Journal of Robotic Surgery, the team found that strategic use of local anesthetic and non-steroidal anti-inflammatory drugs (NSAIDs) plus acetaminophen can effectively control post-surgical pain without narcotics.

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The June 2021 Issue of the Diseases of the Colon and Rectum is out! What are the top 11 reasons to read this month's issue?

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UChicago Medicine has been designated by the Society for Obstetric Anesthesia and Perinatology as a SOAP Center of Excellence for its obstetric anesthesia program.

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UC San Diego Health is conducting the first known randomized, double-blind, placebo-controlled clinical trial looking at cannabis as a potentially effective treatment for acute migraines.

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Cardiologists at Beth Israel Deaconess Medical Center (BIDMC), designed the Safety Assessment of Femoropopliteal Endovascular Treatment With Paclitaxel-coated Devices (SAFE-PAD) study to provide the information necessary to make scientifically-sound regulatory decisions about the safety of these devices.

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Spinal anesthesia is a common intervention for lower-body orthopedic procedures. A potential side effect is post-dural puncture headache (PDPH). Clinicians often use larger needles when performing this technique on older patients. This study found that the incidence of PDPH was not related to needle size.

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Patients undergoing lower body amputations who received PNS implants were able to be discharged home or to rehab earlier with better pain control, required fewer opioids overtime, and were less likely to be readmitted to the hospital in 30 days.

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Erector spinae plane (ESP) blocks enable injection of local anesthetics and steroids along a protective layer surrounding the muscles that support the spine to achieve numbing effects. In this study, patients with acute pancreatitis who received ESP blocks had superior pain control and decreased opioid intake.

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Researchers work to identify optimal volume of local anesthetic needed for erector spinae block in patients with low-back pain.

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In a study of hundreds of patients undergoing total knee or hip replacement, researchers identified a gene called ABCB1 that may predict long-term pain and opioid use.

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Researchers have developed a statistical model to predict the use of long-term opioids after total joint replacement.