Focus: Hidden - Ohio

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Researchers at Case Western Reserve University School of Medicine have developed a method that could make magnetic resonance imaging—MRI—multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis.

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Researchers report encouraging preclinical results as they pursue elusive therapies that can repair scarred and poorly functioning heart tissues after cardiac injury. Scientists from the Cincinnati Children’s Heart Institute inhibited a protein that helps regulate the heart’s response to adrenaline, alleviating the disease processes in mouse models and human cardiac cells. Their data publishes Aug. 22 in the Journal of the American College of Cardiology.

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Youth spend less time in their neighborhoods if area residents have a high fear of crime, according to a new study that used smartphones to track kids’ whereabouts. Adolescents spent over an hour less each day on average in their neighborhoods if residents there were very fearful.

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When drug users go online for the first time to buy opioids, they aren’t looking for the widest selection or the best prices for their illicit purchases, a new study suggests. Researchers found that first-time drug buyers who visited one marketplace on the “darknet” cared only about finding trustworthy sellers.

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U.S. News & World Report has recognized ProMedica Toledo Hospital as one of the best hospitals in Ohio for 2017 – 2018. Toledo Hospital, with a #8 ranking, is the only hospital in northwest Ohio ranked in the top 25 in the state.

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University Hospitals Cleveland Medical Center once again has been recognized as one of the nation's best hospitals for 2017–18 by U.S. News & World Report. UH Cleveland Medical Center was named among the country’s Top 50 in eight methodology-ranked specialties. The annual U.S. News Best Hospitals rankings recognize hospitals that excel in treating patients with the most challenging conditions.

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Rodeo Therapeutics, a new drug development company created by two highly regarded Case Western Reserve University School of Medicine researchers, has raised $5.9 million to develop small-molecule drugs that promote the body’s repair of diseased or damaged tissues.

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The very same treatment that thwarts breast cancer has a dark side – it can fuel the spread of the disease to the lungs. Researchers at The Ohio State University found clues to why it happens, opening up the possibility of interfering with the medication’s downsides while preserving its cancer-fighting properties in breast tissue.

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The International Society for Magnetic Resonance in Medicine (ISMRM) has provided new guidance in the use of contrast agents during MRI scans. Emerging research suggests gadolinium-based contrast agents, injected in a patient’s veins to brighten tissues in MRI images, accumulate in the brain. More than 300 million doses of such drugs have been administered since their introduction in 1987.

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Announcement of new president for University Hospitals Seidman Cancer Center in Cleveland: Theodoros N. Teknos, MD.

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Cytokines might be the key to repairing diabetic nerve damage. Diabetes devastates nerve cells, which can lead to poor circulation, muscle weakness, blindness, and other side effects. The study showed diabetic mice can’t repair nerve cells after damage due to low levels of specific cytokines.

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Call for scholars to apply for research grants for innovative efforts seeking to prevent, treat, or cure blindness.

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Pregnant women and young babies are among those most at risk for complications, hospitalization, and death from the flu. While doctors have long recommended flu shots for protection, experts weren’t exactly sure how the shots affect pregnancy.

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The Nationwide Children’s Hospital Columbus Marathon & ½ Marathon is pleased to announce its “Patient Champions” who will represent 24 of the 26 miles on this year’s course. The other two miles along the Marathon route will be deemed the “Encore Mile” and “Angel Mile,” and many miles will be sponsored by a corporate or community organization.

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When asked to push a simulated wheelchair against increasing resistance, study participants typically exceeded the recommended limits to avoid back injury by nearly 20 percent before they decided to quit.

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Even among people who had just joined a gym and expected to visit regularly, getting paid to exercise did little to make their commitment stick, according to a new study from Case Western Reserve University.

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Diagnosing Alzheimer’s disease and determining a patient’s prognosis is an inexact business, and that stands in the way of better personalized care and advances in treatment. A new study from The Ohio State University has identified a potential new way of confirming the disease and predicting a patient’s outlook.

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Alex Huang has been awarded a $150,000 St. Baldrick’s Foundation Innovation Award.

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CLEVELAND – In the largest nursing home study to date on the effect of a high dose (HD) flu vaccine, researchers found that vaccines with four times the antigen of standard flu (SD) vaccines significantly reduced the risk of respiratory and all-cause hospitalization during flu season. The study found a 12.7 percent relative reduction in the incidence of hospitalization for respiratory illness, such as pneumonia, and an 8.5 percent reduction of all-cause hospitalizations among residents on Medicare who lived at nursing homes that received HD instead of SD flu vaccines. The findings are published in the journal The Lancet Respiratory Medicine.

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According to Todd Russell, MD, FACS, a ProMedica Physician with Jobst Vascular Institute, Rita’s was a silent but very serious risk. He explained, “Her abdominal aortic aneurysm was asymptomatic [showing no symptoms], it was an enlargement of her artery and because it was enlarging significantly, there was a risk the artery wall could become very weak and rupture.”

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Technology is making it easier for patients and providers to interact, thus improving communication, safety and patient-provider relationships. Nationwide Children’s Hospital applies technology in innovative ways to more effectively serve patients, families, staff and the community, earning the hospital the distinction of being named a 2017 Most Wired Hospital for its use of technology to tackle today’s health care problems. In addition to the Most Wired distinction, Nationwide Children’s was also recognized as a 2017 Most Wired Innovator Award Finalist.

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Bowling Green State University faculty and students are working to improve the lives of people across the lifespan, through teaching, research and engagement.

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Daily tomato consumption appeared to cut the development of skin cancer tumors by half in a mouse study at The Ohio State University.

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A psychological intervention implemented to help students cope and learn more in a tough statistics course did more than just help them in the class, a new study found. It also helped them demonstrate better financial literacy and make better health-related decisions.

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University Hospitals Cleveland Medical Center and UH Harrington Heart & Vascular Institute announce the appointment of Mehdi H. Shishehbor, DO, PhD, MPH as Director of Cardiovascular Interventional Center. His areas of expertise include cardiology, vascular medicine, cardiovascular imaging, translational research and minimally invasive, catheter-based procedures such as angioplasty, stent grafts, stenting, atherectomy to treat coronary carotid artery disease, abdominal aortic aneurysms, and peripheral arterial and venous diseases.

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Scientists have found a single protein—Ptbp2—controls a network of over 200 genes central to how developing sperm move and communicate. The protein works by regulating how RNA is processed during each stage of sperm development.

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An international team of scientists has set a new record for creating ice crystals that have a near-perfect cubic arrangement of water molecules—a form of ice that may exist in the coldest high-altitude clouds but is extremely hard to make on Earth.

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High doses of vitamin D taken one hour after sunburn significantly reduce skin redness, swelling, and inflammation, according to double-blinded, placebo-controlled clinical trial out of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center.

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It takes just a few seconds to choose a cookie over an apple and wreck your diet for the day.But what is happening during those few seconds while you make the decision? In a new study, researchers watched in real time as people’s hands revealed the struggle they were under to choose the long-term goal over short-term temptation.

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Researchers from Case Western Reserve University School of Medicine and The Cleveland Clinic designed a way to screen brain tumor cells and identify potential drug targets missed by other methods.

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Laws that require increasingly older kids to sit in car safety seats appear to have limited impact, new research has found.

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The Level I trauma center at University Hospitals Cleveland Medical Center received verification from the American College of Surgeons, the organization that establishes criteria ensuring trauma care capability and institutional performance. UH's trauma center opened late in 2015 and has been operating under provisional status, as is customary until the ACS could conduct a review of the program. The final verification was issued in May.

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Nicole F. Steinmetz, PhD, director of the Center for Bio-Nanotechnology at Case Western Reserve School of Medicine, has received two major grants from the National Institutes of Health to develop microscopic drug-delivery systems for patients living with breast cancer, and patients at risk for serious blood clots.

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The researchers discovered injecting potato virus particles into melanoma tumor sites activates an anti-tumor immune system response. And simultaneously injecting the nanoscale plant virus particles and a chemotherapy drug—doxorubicin—into tumor sites further helps halt tumor progression in mice.

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If your attic is full of stuff you no longer use but can’t bear to give away, a new study may offer you a simple solution. Researchers found that people were more willing to give away unneeded goods that still had sentimental value if they were encouraged to take a photo of these items first.

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A lack of sleep doesn’t just leave you cranky and spoiling for a fight. Researchers at The Ohio State University Institute for Behavioral Medicine Research say it also puts you at risk for stress-related inflammation.

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Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.

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Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation.

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A microscopic fungus called Candida tropicalis triggered gut inflammation and exacerbated symptoms of Crohn’s disease, in a recent study conducted at Case Western Reserve University School of Medicine.

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Results from four recent randomized clinical trials suggest that using medications that offer glucose control while reducing the risk for cardiovascular disease could improve patient outcomes.

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Nationwide Children’s Hospital and Honda announced today a $1 million gift from the automaker to establish the Honda Center for Gait Analysis and Mobility Enhancement designed to enhance pediatric mobility.

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The majority of college-aged male aggressors of physical, sexual and emotional violence also reported being victims of violence themselves, both in childhood and as young adults

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Memories that stick with us for a lifetime are those that fit in with a lot of other things we remember – but have a slightly weird twist. It’s this notion of ‘peculiarity’ that can help us understand what makes lasting memories.

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Doctors at The Ohio State University are testing a high-tech vest which measures fluid inside the lungs from outside a person’s clothing. It could be a new way to prevent repeated trips to the hospital for the nearly six million Americans living with heart failure.

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Nationwide Children’s Hospital celebrated the groundbreaking today of the Big Lots Behavioral Health Pavilion, a freestanding facility fully dedicated to children and adolescents with behavioral health conditions. Thanks to a transformational $50 million gift from Big Lots and Big Lots Foundation, it will be the largest behavioral health treatment and research center dedicated to children and adolescents on a pediatric medical campus in the U.S.

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When you and your family are zooming along the freeway, the last thing you’re worried about is the security of your car’s computer systems. That’s one reason Ohio State University Associate Professor Emre Koksal devotes most of his time to thinking about how to protect vehicles from cyberattacks.

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An area of West Antarctica more than twice the size of California partially melted in 2016 when warm winds forced by an especially strong El Niño blew over the continent, an international group of researchers has determined.

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An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ’s developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells. The scientists report online in Nature on June 14 that their bioengineered human liver tissues still need additional rounds of molecular fine tuning before they can be tested in clinical trials.