Hydroxychloroquine (Plaquenil®), especially at the higher standard dose of 400 mg per day, independently decreases the risk of cardiovascular morbidity in people with rheumatoid arthritis, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
People age 30 or over with autoimmune, inflammatory diseases like rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease, may benefit from vaccinations for the viral infection herpes zoster, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Use of antibiotics is associated with an increased risk of children developing juvenile idiopathic arthritis, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Boston.
A study by researchers at Hospital for Special Surgery identifies a new cell signaling pathway that contributes to the development and progression of inflammatory bone erosion, which occurs in patients with rheumatoid arthritis. The study was published online in the Journal of Clinical Investigation.
Researchers at the University of Illinois at Chicago College of Medicine have shown for the first time how the activation of a receptor provokes the inflammation and bone degradation of rheumatoid arthritis -- and that activation of this one receptor, found on cells in the fluid of arthritic joints, is all that is required.
A team of researchers from Wayne State University and collaborators from Duke University Medical Center recently published a paper in the Journal of Consulting and Clinical Psychology that explores two psychological interventions separately and in combination to determine their effectiveness in offering relief to RA patients.
Most people associate arthritis with aging, but the fact is, one in 1,000 children is diagnosed with juvenile arthritis. Stony Brook Children’s Hospital’s Pediatric Rheumatologist Dr. Julie Cherian addresses the most common questions from parents — and discusses what they can do if they suspect their child may have arthritis.
Mice consuming a supplement of omega 3 fatty acids had healthier joints than those fed diets high in saturated fats and omega 6 fatty acids, according to Duke Medicine researchers.
Improvements in implant design have prompted more people with severe arthritis in their ankle to consider ankle replacement to relieve pain. The newest implant is considered by many to be an advance over previous models, designed to better reproduce the ankle’s natural motion and last longer.
Researchers at Benaroya Research Institute at Virginia Mason (BRI) used cutting-edge tetramer technology developed at BRI to find the T cells that drive rheumatoid arthritis (RA).
Investigators at UAB have teamed with the arthritis support community CreakyJoints.org to launch a study to incorporate electronic devices to capture important information on conditions such as rheumatoid arthritis from patients and physicians. The effort is funded by a $1 million award from the Patient-Centered Outcomes Research Institute.
Rheumatoid arthritis patients are likelier than the average person to develop chronic kidney disease, and more severe inflammation in the first year of rheumatoid arthritis, corticosteroid use, high blood pressure and obesity are among the risk factors, new Mayo Clinic research shows. Physicians should test rheumatoid arthritis patients periodically for signs of kidney problems, and patients should work to keep blood pressure under control, avoid a high-salt diet, and eliminate or scale back medications damaging to the kidneys, says senior author Eric Matteson, M.D., Mayo rheumatology chair. The study is published in the American Journal of Kidney Diseases, the National Kidney Foundation journal.
Gout is on the rise among U.S. men and women, and this piercingly painful and most common form of inflammatory arthritis is turning out to be more complicated than had been thought. The standard way to check for gout is by drawing fluid or tissue from an affected joint and looking for uric acid crystals, a test known as a needle aspirate. That usually works, but not always: In a new Mayo Clinic study, X-rays known as dual-energy CT scans found gout in one-third of patients whose aspirates tested negative for the disease. The CT scans allowed rheumatologists to diagnose gout and treat those patients with the proper medication.
The adult offspring of parents who were addicted to drugs or alcohol are more likely to have arthritis, according to a new study by University of Toronto researchers. Investigators examined a group of 13,036 adults and found that 20.4 per cent of respondents had been diagnosed with arthritis by a medical professional.
While many overweight patients intend to lose weight after joint replacement, a study at Hospital for Special Surgery finds that although some are able to achieve this goal, equal numbers of patients actually gain weight after hip or knee replacement. Patients who lose weight have better joint replacement outcomes in terms of function and activity level two years down the road.
Total knee replacement for patients with rheumatoid arthritis (RA) presents greater challenges, as RA patients generally have more health concerns than patients with osteoarthritis. However, researchers at Hospital for Special Surgery found that same-day bilateral knee replacement surgery is safe for select patients with rheumatoid arthritis.
After hip replacement surgery, many patients are anxious to resume driving. A new study using a sophisticated interactive driving simulator finds that patients can safely get back behind the wheel after four weeks, challenging the conventional wisdom that they should wait six weeks.
One of the biggest concerns of patients considering knee replacement is the amount of pain they will have after surgery. Although it is a very successful operation overall to relieve arthritis pain and restore function, persistent postoperative pain can be a problem for some individuals. Researchers determined which patients were at highest risk for increased postoperative pain based on demographic and surgical variables.
Shoulder arthritis is a common problem for rheumatoid arthritis patients: pain and difficulty moving their arms can grow so severe that daily tasks and sleep become difficult. If medication and physical therapy aren’t enough, shoulder replacement surgery is a common next step. Despite surgical challenges with some rheumatoid arthritis patients, the procedure improves range of motion and reduces pain in nearly all cases, especially for those with intact rotator cuffs, a Mayo Clinic study shows. The findings are published in the Journal of Shoulder and Elbow Surgery.
University of Utah researchers have discovered a naturally occurring genetic variation in mice that predisposes carriers toward developing severe, inflammatory arthritis.
An experimental compound developed by scientists from The Scripps Research Institute's Florida campus is capable of significantly reducing joint inflammation in animal models of rheumatoid arthritis.
Patients with rheumatoid arthritis, lupus and other chronic forms of inflammatory arthritis can face life-threatening complications, and heart disease tops the list. People with such rheumatic diseases are twice as likely as the average person to develop heart problems.
Collaborating with researchers from the Northwestern University Feinberg School of Medicine in Chicago, a research team at Wayne State University’s School of Medicine led by Kezhong Zhang, Ph.D., has contributed to an important discovery in the inflammatory stress mechanism and specific inhibitor for the treatment of rheumatoid arthritis.
A study presented at the American Public Health Association shows the benefits of an exercise program offered by Hospital for Special Surgery in senior centers in New York City's Chinatown and in Flushing, Queens
Researchers have linked a species of intestinal bacteria known as Prevotella copri to the onset of rheumatoid arthritis, the first demonstration in humans that the chronic inflammatory joint disease may be mediated in part by specific intestinal bacteria. The new findings by laboratory scientists and clinical researchers in rheumatology at NYU School of Medicine add to the growing evidence that the trillions of microbes in our body play an important role in regulating our health.
Experiments by scientists at Johns Hopkins and in Boston have unraveled two biological mechanisms as the major cause of protein citrullination in rheumatoid arthritis. Protein citrullination is suspected of sparking the immune system and driving the cascade of events leading to the disease.
Dipeptidyl peptidase-4 inhibitors commonly used to control blood sugar levels in people with type 2 diabetes may also reduce the risk of autoimmune diseases in these patients, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Treating rheumatoid arthritis patients with intensive pharmacological agents, such as biologic drugs, may reduce the need for orthopedic joint surgery, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Tumor necrosis factor inhibitor drugs (commonly called Anti-TNFs) modestly reduce the risk of acute coronary syndrome, such as heart attacks and angina, in rheumatoid arthritis patients whose inflammation places them at higher risk of developing coronary heart disease, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Patients with rheumatoid arthritis may not need to halt use of their antirheumatic drugs prior to surgery due to fears of increased infection risk, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
People with psoriatic arthritis who receive early, aggressive pharmacologic intervention following a treat-to-target approach show better outcomes than those who receive standard care, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Osteoarthritis patients who engage in regular physical activity have higher Quality- Adjusted Life Years, a standard measurement of quality of life and cost-effectiveness of medical treatment, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Starting with a combination of three traditional disease-modifying antirheumatic drugs (called DMARDs) for treating early rheumatoid arthritis is more cost-effective long term, with comparable benefits, than using either an immediate or step-up approach with anti-tumor necrosis factor (called Anti-TNFs) drugs and methotrexate, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Children with juvenile idiopathic arthritis who receive early, aggressive therapy with a combination of medications achieve clinical inactive disease status faster than they would with less aggressive therapy, according to new research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Using a combination of three traditional disease-modifying antirheumatic drugs for treating recent-onset rheumatoid arthritis is more efficient than a monotherapy approach using methotrexate, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in San Diego.
Using a combination of three traditional disease-modifying antirheumatic drugs for treating recent-onset rheumatoid arthritis is not only more cost-effective, but results in better long-term worker productivity than a monotherapy approach using methotrexate, according to new research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
A high percentage of rheumatoid arthritis patients discontinue triple therapy, a combination of disease-modifying antirheumatic drugs, after one to two years, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Rituximab (Rituxan®) — a drug commonly used rheumatoid arthritis, granulomatosis with polyangiitis (formerly Wegener’s), and certain types of cancers — may be a safe and effective treatment for immunoglobulin G4-related disease (commonly called IgG4-RD), according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Learning that your child has arthritis can lead to a number of questions and concerns about treatment options and prognosis. But, partnering with your child and his or her rheumatologist in shared decision making about their health care can lead to better outcomes overall, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego.
There has been a progressive decline in the levels of disease activity and disability among children with juvenile idiopathic arthritis over the past 25 years, according to research presented this week at the American College of Rheumatology Annual Meeting in San Diego. This research confirms the notion that recent advances in the management of the disease have led to a substantial improvement in health outcomes for children living with it.
People with rheumatoid arthritis and other chronic inflammatory conditions are at higher risk of heart disease. Who is in the most danger, why and how best to prevent and detect cardiovascular complications are important questions for physicians and researchers.
Researchers at Hospital for Special Surgery found that people who lacked good social connections were much more likely to experience serious, ongoing pain following total hip replacement surgery two or more years after the procedure.
Delaying treatment for rheumatoid arthritis could greatly increase the likelihood that patients will suffer joint damage and experience disability two years out, according to a new study from Hospital for Special Surgery.
A team led by scientists at The Scripps Research Institute has identified key signaling proteins in the inflammation process that contribute to the development of inflammatory diseases such as rheumatoid arthritis, psoriasis, sepsis and inflammatory bowel diseases.
The results of a new study by bone and joint experts at Rush University Medical Center suggest that patients with knee osteoarthritis (OA) who wear flat, flexible footwear, which allows natural foot mobility and provide sufficient support for the foot, had significant reduction in knee loading—the force placed upon the joint during daily activities.
The American Autoimmune Related Diseases Association (AARDA) and Washington University will host an Autoimmune Disease Weekend on the university’s St. Louis campus the first weekend of October.
In Nature Reviews Immunology, William Gause of Rutgers New Jersey Medical School and colleagues have described exciting progress in harnessing the human immune system's reaction to the presence of parasitic worms, as a way to lessen susceptibility to type 1 diabetes and other autoimmune and inflammatory diseases, as well as for use in promoting wound healing.
A new study published today in Arthritis Research & Therapy provides the first genomic characterization of remission in juvenile rheumatoid arthritis patients.
Hospital for Special Surgery in New York City along with two other institutions have been awarded $1 million from the Arthritis Foundation to validate the use of new MRI (magnetic resonance imaging) techniques and newly identified biomarkers to solve this vexing problem.
Dermatology researcher Nicole Ward, PhD, has earned her third National Institutes of Health grant in a year – including two that scored in the first percentile. With this most recent award, an R21, she will investigate the role the nervous system plays in psoriasis.
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