In work to be presented at the ASCB/IFCB meeting in Philadelphia, researchers from the Institut Curie in Paris report that they have evidence of a coordinated attack on the basement membrane of human colon cells by cancer cells in situ and CAF cells in the extracellular matrix that begins long before the actual translocation of cancer cells.
Now bioengineering researchers at Temple University in Philadelphia have come up with an experimental workaround—a synthetic pediatric blood-brain barrier on a small chip—and have tested it successfully using rat brain endothelial cells (RBECs) from rat pups and human endothelial cells.
Jae-Won Shin and David Mooney of Harvard University’s Wyss Institute for Biologically Inspired Engineering in Cambridge, MA, describe building a three-dimensional (3D) hydrogel system with tunable stiffness to see how relative stiffness of the surrounding ECM affected the resistance of human myeloid leukemias to chemotherapeutic drugs.
The even more surprising answer was that rescuing the Golgi reduced Aβ accumulation significantly, apparently by re-opening a normal protein degradation pathway for the amyloid precursor protein (APP).
The average animal cell is 10 microns across but why? Princeton bioengineers take their story of gravity in cells one step further at ASCB, describing how cells manage to support thousands of membrane-less compartments inside the nucleus
A new method uses photoactivatable complementary fluorescent proteins (PACF) to observe and quantify protein-protein interactions in live cells at the single molecule level.
The American Society for Radiation Oncology (ASTRO) received three 2014 MarCom Awards.
The search for a living laboratory model of Alzheimer’s disease (AD)—the so-called “Alzheimer’s in a dish”—has a new candidate. Håkan Toresson and colleagues at Lund University in Sweden report success in creating induced neurons that model Alzheimer’s by starting with fibroblasts taken from skin biopsies.
• Decreased blood levels of a protein called Klotho increases the risk of heart disease in mice with chronic kidney disease. • If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.
• A simple model using 5 commonly available variables from electronic health records adequately discriminates between socially disadvantaged individuals with chronic kidney disease who will and will not progress to kidney failure.
The national Measure Up/Pressure Down® hypertension campaign recognized 43 medical groups across the nation for their blood pressure control and improvement rates on a virtual campaign anniversary event today. Awards were presented to participating groups and health systems in specific categories – best control rate, most improvement, and quickest improvement – as well as progress towards campaign goal of 80% hypertension control by 2016.
The Jonas Center for Nursing and Veterans Healthcare (Jonas Center), Khan Academy, and the American Association of Colleges of Nursing (AACN) today announced the continuation of a groundbreaking partnership to produce innovative, online healthcare content for a global audience of faculty, students, practitioners, and consumers.
To advance scientific understanding of how hormone disorders can affect men and women differently, the Endocrine Society has introduced policies to improve reporting of the sex of research subjects in its journals.
The Ku Klux Klan’s failure to defeat the black civil rights moment is well documented, but the group’s lesser-known legacy may be its lasting impact on the U.S. political system, according to a new study.
On the eve of the arrival of negotiators at a crucial UN conference on climate change, a new report shows that, despite public commitments to protect Peru’s forests, the first Amazonian host of the UN COP is ignoring the real drivers of deforestation and failing to safeguard the rights of indigenous peoples. This, despite the fact that these peoples occupy approximately one third of the Peruvian Amazon and offer the best chance of defending the country’s precious forests.
The following articles are freely available online from Physics Today (www.physicstoday.org), the most influential and closely followed magazine in the world devoted to physics and the physical science community.
Providing public parks and walking and biking trails is the most cost-effective strategy to increase physical activity among large populations in urban areas, finds a new systematic review in the American Journal of Health Promotion.
The way medical doctors assess, treat and refer racial and ethnic minorities for mental health services may contribute to disparities in their use, according to a new study in Health Services Research.
The ability to detect when to harvest “climacteric” fruits -- such as apples, bananas, pears and tomatoes -- at the precise moment to ensure “peak edibleness” in terms of both taste and texture may soon be within reach for farmers, thanks to the work of a team of researchers from Saint Joseph University in Lebanon and the Université de Bretagne Occidentale de Brest in France.
A new report from the American Institute of Physics (AIP) Statistical Research Center has found that the number of Hispanic students receiving bachelor’s degrees in the physical sciences and engineering has increased over the last decade or so, passing 10,000 degrees per year for the first time in 2012. The overall number of U.S. students receiving degrees in those fields also increased over the same time, but it increased faster among Hispanics.
Primary care that includes mental health screenings and treatments that take into account a patient’s language and cultural background can help address mental health care disparities among ethnic minorities, according to psychologists, physicians and other health care experts writing in a special issue of Psychological Services, published by the American Psychological Association.
The first presidential portraits created from 3-D scan data are now on display in the Smithsonian Castle. The portraits of President Barack Obama were created based on data collected by a Smithsonian-led team of 3-D digital imaging specialists and include a digital and 3-D printed bust and life mask. A new video released today by the White House details the behind-the-scenes process of scanning, creating and printing the historic portraits.
Yesterday, the Centers for Medicare & Medicaid Services (CMS) released a new proposal to strengthen the Medicare Shared Savings Program for Accountable Care Organizations (ACOs). The proposed rule reflects input from program participants, experts, consumer groups, and the stakeholder community at large.
Researchers from the Joslin Diabetes Center and the Department of Medicine at Harvard Medical School shed light on how changes to a mother’s metabolism lead to increased risk of insulin resistance, obesity and other problems in offspring.
The ACR Mammography Case Review (MCR) Online improves physicians’ breast cancer detection skills by supplementing real world experience with electronic cases. This self-paced eLearning program features a state-of-the-art interface with an interactive image detection mechanism to enhance learning.
Researchers presented two preliminary studies at ASN Kidney Week 2014 in Philadelphia, PA, that demonstrate the potential of a small-molecule inhibitor of NHE3 to help reduce phosphorus absorption in patients with kidney disease. Patients with reduced kidney function are unable to maintain normal levels of phosphorus, which can lead to hyperphosphatemia.
The Society for Women's Health Research responds to FDA data showing women and minorities are not studied enough in medical research.
Diagnosing HIV and other infectious diseases presents unique challenges in remote locations that lack electric power, refrigeration, and appropriately trained health care staff. To address these issues, researchers funded by the National Institutes of Health (NIH) have developed a low-cost, electricity-free device capable of detecting the DNA of infectious pathogens, including HIV-1.
Today AACC released a position statement in response to the Food and Drug Administration’s (FDA’s) proposal for oversight of laboratory developed tests, asserting that most laboratory developed tests are sufficiently regulated by the Centers for Medicare and Medicaid Services, and that too much additional FDA oversight could prevent labs from helping underserved patient populations.
Image Wisely.org now offers online educational materials for fluoroscopy, computed tomography and nuclear medicine exams. Fluoroscopy is the latest addition to Image Wisely®, which helps radiology providers optimize radiation dose and provide safe, effective imaging care.
In certain circumstances, women may be more effective than men when negotiating money matters, contrary to conventional wisdom that men drive a harder bargain in financial affairs, according to a new meta-analysis published by the American Psychological Association.
Milken Institute School of Public Health (Milken Institute SPH) at the George Washington University will hold an event on December 5 to highlight the challenges and opportunities faced by high school students with Autism Spectrum Disorder (ASD) as they transition from high school to adulthood. The event will highlight the work of the Autism Transition Project (ATP), a two-year research initiative that aims to better understand from the school and family perspective what these challenges and opportunities are as high school students prepare for the adult world.
A special issue of the Journal of the American College of Radiology (JACR®) provides practical guidance on implementing radiology quality improvement projects. Topics include preplanning, gaining nonradiologist buy-in and strategies to influence referring physician ordering.
When a revered research institution reaches out to a fine artist to create its first ever artist-in-residency program, we should all sit up and take notice. This month, FermiLab, the celebrated particle physics research laboratory, announced a year-long partnership with artist Lindsay Olson.
Milken Institute School of Public Health at the George Washington University (Milken Institute SPH) in collaboration with the Jayne Koskinas Ted Giovanis Foundation for Health and Policy today launched a new seminar series on pressing topics in the arena of health policy. The dialogue series will include nationally-recognized speakers along with reaction and commentary by other leaders in the field as well as audience participation.
The U.S. Food and Drug Administration took a step to help consumers make informed food selections with two rules issued Nov. 25, 2014 that require calorie information to be listed on menus in chain restaurants. The Obesity Society commends efforts to provide more information to consumers so they are better able to make informed decisions regarding their food choices and their health.
The National Communication Association (NCA) honored 33 members with awards Saturday night at its 100th Annual Convention in Chicago. The convention celebrated a century of of teaching, research, and service within the Communication discipline.
Researchers have identified genetic markers that may help to identify individuals at risk for acute kidney injury (AKI) in the hospital setting. Presented at ASN Kidney Week 2014 in Philadelphia, PA, the study offers new clues about the development of AKI and could lead to potential therapeutic interventions.
Researchers from Harvard and MIT have found that fluctuations in outside temperature create convection currents within termite mounds to ventilate the living space -- work at the 67th annual meeting of the American Physical Society (APS) Division of Fluid Dynamics, held November 23-25 in San Francisco.
Each year, the more than 2 million tractor-trailer trucks that cruise America's highways consume about 36 billion gallons of diesel fuel, representing more than 10 percent of the nation's entire petroleum use. That fuel consumption could be reduced by billions of gallons a year through the use of drag-reducing devices on trucks, according to studies by researchers at Lawrence Livermore National Laboratory.
Espresso-loving astronauts, rejoice! You may soon be able to enjoy your beloved beverage in space, thanks to a new cup designed specifically to defy the low-gravity environments encountered aboard the International Space Station (ISS).
If you've ever watched a dog drink water, you know that it can be a sloshy, spilly, splashy affair -- in other words, adorable. Behind all of the happy, wet messes, however, lies the mechanical logic of carnivorous compensation -- dogs splash when they drink because they have the cheeks of a predatory quadruped. By studying the drinking habits of various dog breeds and sizes, researchers have recently identified and modeled the fluid dynamics at play when dogs drink water.
Advanced practice clinicians, such as nurse practitioners and physician assistants, are 34 percent more likely than primary care physicians to prescribe an imaging exam for patients, according to a Harvey L. Neiman Health Policy Institute study published in JAMA Internal Medicine.
If you've ever looked closely at the dried rings whisky leaves behind in a glass, you may be among the few who've noticed just how stunningly beautiful they can be. But what's behind whisky's "particle patterning"?
Jackson Pollock, one of the greatest American artists of the 20th century, revolutionized abstract expressionist painting in the mid-20th century with his unique "drip" technique -- masterpieces of densely tangled lines of color that Pollock often created from thinned household enamel paints. Now, an experimental technique developed by fluid dynamicists at the Universidad Nacional Autónoma de México in Mexico City may help reveal exactly how Pollock produced certain features in his paintings.
The Radiation Oncology Institute (ROI) is requesting research proposals to examine the comparative value of radiation therapy and will provide support for the selected research project in the amount of $200,000 total for up to two years.
Olympic sailors tip their masts precariously close to the water's surface while turning, right their vessels at what looks like the last possible moment, and bounce up and down over the edge of their boats on the straightaways. Every aspiring Olympic sailor must master these unsteady sail propulsion techniques, but there is no scientific literature that explains exactly how the moves increase a boat's speed. A team of researchers from Cornell University is working to change that.
Journalists are invited to participate in as interactive webcast streamed live from the 67th annual meeting of the American Physical Society’s Division of Fluid Dynamics (APS-DFD), held November 23-25, 2014 in San Francisco, Calif.
Over the course of the last 10 years, the Institute for Infectious Animal Diseases (IIAD), a Department of Homeland Security (DHS) Science and Technology Center of Excellence, has made significant contributions to research on biological threats that could occur from intentional or accidental introduction of transboundary animal or zoonotic diseases.
Teens prescribed anti-anxiety or sleep medications may be up to 12 times more likely to abuse those drugs illegally than teens who have never received a prescription, often by obtaining additional pills from friends or family members, according to new research published by the American Psychological Association.
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