Researchers in Cleveland, Ohio have taken a significant step toward defeating antibiotic-resistant infections by combining two different antibiotics that each block a different kind of drug-destroying enzyme secreted by bacteria.
Specific cells in the retina trigger inflammation and vision impairment associated with diabetes, according to new research out of Case Western Reserve University School of Medicine.
Genetic mutations can increase a person’s cancer risk, but other gene “enhancer” elements may also be responsible for disease progression, according to new research out of Case Western Reserve University School of Medicine.
Researchers at The Ohio State University Ross Heart Hospital and Nationwide Children’s Hospital have shown early treatment with eplerenone can improve heart function in young boys with Duchenne muscular dystrophy (DMD) and stabilize heart function in older boys with the disease.
Researchers at The Ohio State University have discovered that food waste can partially replace the petroleum-based filler that has been used in manufacturing tires for more than a century. In tests, rubber made with the new fillers exceeds industrial standards for performance, which may ultimately open up new applications for rubber.
Meniscal repairs are one of the most common orthopedic surgeries in the U.S., but about 15 percent of them fail, requiring the patient to undergo a second surgery. Many have assumed that an increased body mass index (BMI) is a good predictor of whether a meniscal repair will fail, since more weight translates to more pressure on the knee joint. However, a new study from The Ohio State University Wexner Medical Center shows that BMI has no effect on whether or not meniscus repair surgery will fail.
Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center are teaming up to take on the rising problem of antibiotic resistance.
Our fractured political climate in the United States might be made worse by how we approach difficult problems, researchers say in the journal Science.A team of political scientists suggests rather than asking citizens “What do you want,” questions should be asked in a deliberative frame: “What should we do?”
A Whitehall, Ohio man is the first in the U.S. to undergo a new treatment designed to remove excess fluid from hospitalized patients suffering from congestive heart failure. The trial procedure occurred last week at The Ohio State University Ross Heart Hospital.
As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC’s form also ages, contributing to the problem. In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs are created.
Researchers from Case Western Reserve University School of Medicine, the National Institute of Standards and Technology, and Karolinska Institute in Sweden discovered that a specific enzyme in the brain could reduce the formation of debilitating brain lesions in the two diseases.
Even nations can have friends of friends, a new study has found. Results suggest these indirect relationships have a surprisingly strong ability to prevent major conflicts, and that international military alliances may matter more than we typically expect.
A habitation system designed by Ohio State College of Engineering students could make deep space living more healthy and efficient for astronauts on the Journey to Mars. The project is part of NASA’s eXploration Systems and Habitation (X-Hab) Academic Innovation Challenge series.
Becker's Hospital Review has named ProMedica to its "150 Top Places to Work in Healthcare | 2017" list. This is the third year in a row ProMedica received this recognition.
Researchers at the University of Cincinnati (UC) College of Medicine have discovered a new potential strategy to personalize therapy for brain and blood cancers.
In a new, first-of-its-kind study, researchers from Case Western Reserve University School of Medicine have found a 700-percent surge in infections caused by bacteria from the Enterobacteriaceae family resistant to multiple kinds of antibiotics among children in the US. These antibiotic resistant infections are in turn linked to longer hospital stays and potentially greater risk of death.
Story about the first patient enrolled in the new national phase I trial studying the side effects and best dose and schedule of pembrolizumab, an immunotherapy drug, when given together with chemotherapy and radiation therapy following surgery for very high risk head and neck cancer. Pembrolizumab is one of the first immunotherapy drugs.
Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies. Reporting their data Feb. 22, the international research team conducted the study in mouse models of lysosomal storage disease and in cells from blood samples donated by people with Gaucher disease.
ProMedica Toledo Hospital is pleased to announce it has received the 2017 America’s 100 Best Hospitals AwardTM from Healthgrades, the leading online resource for comprehensive information about physicians and hospitals. For the third year in a row, ProMedica Toledo Hospital is among the top two percent of more than 4,500 hospitals nationwide for its clinical excellence.
Eating a Mediterranean diet could decrease the chances an overweight person will experience regular pain, new research suggests.
As mindfulness practices rise in popularity and evidence of their worth continues to accumulate, those who work with aging populations are looking to use the techniques to boost cognitive, emotional and physiological health. But studies so far have shown mixed results in the elderly.
Many of the toughest decisions faced by cancer patients involve knowing how to use numbers -- calculating risks, evaluating treatment options and figuring odds of medication side effects. But for patients who aren’t good at math, decision science research can offer evidence-based advice on how to assess numeric information and ask the right questions to make informed choices.
Even those who follow science may be surprised by how quickly international collaboration in scientific studies is growing, according to new research. The number of multiple-author scientific papers with collaborators from more than one country more than doubled from 1990 to 2015, from 10 to 25 percent, one study found.
Our nation’s health care system is a mess. The industry spends $3 trillion annually and constitutes more than 17 percent of the nation’s GDP. For patients and their families, shouldering the burden of rising health care costs often leads to financial hardship and is the No. 1 cause of personal bankruptcy. Escalating health care costs lead many to forgo care, or patch together payments while neglecting other basic needs.
Max Wiznitzer, MD, has a longstanding interest in neurodevelopmental disabilities, including autism.
Genomic testing of biopsies from patients with deadly, treatment-resistant cancerous blood syndromes called histiocytoses allowed doctors to identify genes fueling the ailments and use targeted molecular drugs to successfully treat them. Researchers report their data in Journal of Clinical Investigation Insight (JCI Insight). They recommend the regular use of comprehensive genomic profiling at diagnosis to positively impact clinical care,
Getting a tattoo may hurt, but giving one is no picnic, either. That’s the finding of the first study ever to directly measure the physical stresses that lead to aches and pains in tattoo artists—workers who support a multibillion-dollar American industry, but who often don’t have access to workers’ compensation if they get injured.
A new investigational delivery method for localized vaginal estrogen therapy that utilizes an applicator free softgel to alleviate moderate-to-severe vaginal pain during intercourse (dyspareunia), a symptom of vulvar and vaginal atrophy (VVA), received high rates of patient satisfaction among post-menopausal women, according to post-trial survey results published in the journal Menopause. “These survey results show that something as simple as a change to a more elegant delivery system that is easier to use and not messy might empower more post-menopausal women to seek prescription treatment for VVA, and perhaps help them stay with the application guidelines for longer,” said study first author Sheryl Kingsberg, PhD, Division Chief, OB/GYN Behavioral Medicine, UH Cleveland Medical Center.
Considered as a whole, one finding stood out that may prompt institutions to reflect on their priorities. That finding: “Good teaching is the primary means through which institutions affect students.”
Women have claimed for years that their bodies react differently whether they’re pregnant with a boy or girl. Now evidence, published by Ohio State University researchers shows the sex of a baby is associated with pregnant women’s immune responses.
Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations
Doctors have long understood that antibiotics that protect infants from infection also can disrupt the normal growth of their gut bacteria. However, a new study reveals that the consequences of routine antibiotic use may be deeper and longer lasting than expected. The study, published Feb. 8 in Science Translational Medicine, shows that short-term disruption of gut bacteria makes infant mice more likely to develop pneumonia. It also makes them more likely to die from it.
A Case Western Reserve University researcher found and videoed the Cuatro Ciénegas cichlid, Herichthys minckleyi, using the reproductive strategy called sneaking to insert himself between a mating pair and pass his DNA onto the next generation.
Researchers at Case Western Reserve University will use a $2 million grant from the National Institutes of Health to develop and test a small, portable blood-adhesion monitor for sickle cell disease patients. They hope to make the device as useful as at-home insulin monitors diabetes patients use to manage their disease.
ProMedica, an Ohio-based health system, and Paramount Health Care, a health insurance provider affiliated with ProMedica, are collaborating with American Well, a leading telehealth company, to offer live video medical visits 24 hours a day, seven days a week.
Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.
Leading neuroscientists have clarified the role of a controversial immune system protein in Alzheimer’s disease, showing it has opposing effects in early and late stages of the disease. Their discovery unites previous studies that left researchers conflicted and showed the protein both exacerbates and ameliorates disease symptoms. The updated model of disease progression, published in the Journal of Neuroscience, also highlights the need to align certain therapies with disease stages when treating the 1 in 9 Americans over 65 living with Alzheimer’s.
Tween clothing retailer, Justice presented Nationwide Children’s Hospital officials with a check totaling $1,472,837. The amount represented the total dollars raised during Justice’s national holiday campaign that benefited The Research Institute at Nationwide Children’s.
Case Western Reserve School of Medicine has appointed Bernard Boulanger, MD, MBA, as senior associate dean for The MetroHealth System. In his new role, effective March 1, Dr. Boulanger will oversee the planning, assessment, and implementation of the school’s teaching and research programs at the health system. He will also serve as professor of surgery at Case Western Reserve University School of Medicine.
Naveen Uli, MD, associate professor of pediatrics and Michiko Watanabe, PhD, professor of pediatrics at Case Western Reserve University School of Medicine served as editors for the special issue of Birth Defects Research Part C: Embryo Today.
Standards of care are ever evolving, but now front-line pediatricians from Case Western Reserve University School of Medicine have assembled the latest data about the varied causes of DSD, complete with clinical vignettes and appropriate management plans.
As the number of grandparents caring for grandchildren full-time continues to swell, so do the stress-induced health risks associated with such a demanding responsibility. Now, a four-year, $2 million grant from the National Institutes of Health will allow researchers at Case Western Reserve University’s Frances Payne Bolton School of Nursing to refine and test a new approach to help grandmothers manage the stresses of the this new role—and hopefully reduce the emotional and physical fallout that often results.
Unique research being done at OSU Wexner Medical Center is changing the way doctors treat one type of irregular heartbeat called atrial fibrillation. Scientists here are the only ones in the world studying revived human atria, donated after a heart transplant, and translating their findings to improve treatment.
A Case Western Reserve University School of Medicine researcher has received a $2.5 million grant from Gilead Sciences, a California-based biopharmaceutical company, to see if two so-far separately-used AIDS treatments are even more effective when used as a pair.
News release about the first person enrolled in the first stem cell trial for cystic fibrosis.
Anti-inflammatory diets – which tend to be high in vegetables, fruits, fish and whole grains – could boost bone health and prevent fractures in some women, a new study suggests. Researchers examined data from the landmark Women’s Health Initiative to compare levels of inflammatory elements in the diet to bone mineral density and fractures and found new associations between food and bone health.
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