More than $9 million in federal grants will help fund researchers in the Ohio State University Davis Heart and Lung Research Institute (DHLRI) and their collaborators across the university campus to investigate new causes and treatments for cardiovascular disease.
Two internationally recognized research leaders from UH Cleveland Medical Center and Case Western Reserve University School of Medicine have received Outstanding Investigator Awards from the NIH. The 7-year, $6.7 million dollar awards will advance molecular studies of colon cancer and age-related cardiovascular risks.
COLUMBUS, Ohio – The time of day that breast cancer chemotherapy drugs are given affects the amount of damaging inflammation in the body, a new study in mice suggests.
A University of Cincinnati study reported that patients who sustained a concussion, followed by symptoms of visual dysfunction, experienced delayed central and peripheral vision reaction times.
Xinglong Wang’s team published a study in the January 2017 issue of Molecular Therapy that is seen as confirming the relevance of this neurotoxic pathway, according to an accompanying editorial by Eloise Hudry, PhD, of the Alzheimer’s Disease Research Unit at Harvard Medical School. This paper also confirms TDP-43 inhibition as a viable therapeutic option for the treatment of neurologic disorders, including Alzheimer disease.
COLUMBUS, Ohio – Satirical news programs, often dismissed as mere entertainment, have real political effects on the people who watch them, new research suggests.A study found that people chose satirical news that matched their pre-existing attitudes – liberal or conservative – and that watching satirical news reinforced those attitudes as much as watching serious news.
TaxSlayer will donate 15 percent of new e-filers’ tax preparation fees to support life-saving research and care at Nationwide Children’s beginning Jan. 25.
Children with autism may benefit from fecal transplants – a method of introducing donated healthy microbes into people with gastrointestinal disease to rebalance the gut. Behavioral symptoms of autism and gastrointestinal distress often go hand-in-hand, and both improved when a small group of children with the disorder underwent fecal transplant and subsequent treatment.
The number of U.S. women taking maternity leave has not changed in 22 years despite factors that suggest it should be increasing, a new study found. During the same time, the number of fathers taking paternity leave more than tripled.
Brian T. Grimberg, PhD, assistant professor of international health, infectious diseases, and immunology at the Center for Global Health and Diseases at Case Western Reserve University School of Medicine, has received a Fulbright U.S. Scholar Program Award.
In a photo analysis study of soccer headers, University of Cincinnati researchers noticed female soccer players had their eyes closed 90 percent of the time. As a first step toward determining if less visual awareness might expose players to a higher risk of injury, the study wanted to quantify whether female athletes closed their eyes more frequently than male counterparts.
A team of researchers from Case Western Reserve University School of Medicine has helped uncover the elusive structure of a cancer cell receptor protein that can be leveraged to fight disease progression.
Researchers here have made a discovery in materials science that sounds like something from the old Saturday morning cartoon Super Friends: They’ve found a way to deactivate “nano twins” to improve the high-temperature properties of superalloys that are used in jet engines.The advance could speed the development of powerful and environmentally friendly turbine engines of all sorts, including those used for transportation and power generation.
Depression is very common during pregnancy, with as many as one in seven women suffering from the illness and more than a half million women impacted by postpartum depression in the U.S. alone. The disorder not only affects the mother’s mood, but has also been linked to influencing the newborn’s development, according to recent research. In a study published in the journal Psychoneuroendocrinology, research from The Ohio State University Wexner Medical Center found that BDNF levels change during pregnancy, and can cause depression in the mother and low birth weight in the baby.
Micro-Leads Inc. is among three recipients around the world awarded $1 million to develop an advanced bioelectronics medicine device for GlaxoSmithKline’s (GSK) Bioelectronics Innovation Challenge.
New research out of Case Western Reserve University School of Medicine describes a mechanism by which an essential quality control system in cells identifies and destroys faulty genetic material. The findings were published online December 23 in Nature Communications.
The Leona M. and Harry B. Helmsley Charitable Trust awarded a $2.5 million grant to the Case Western Reserve University School of Medicine to continue research on a new form of insulin for those living with type 1 diabetes (T1D).
When anthropologists of the future find our fossilized teeth, what will they be able to conclude about our lives?Debbie Guatelli-Steinberg has an idea.
The humble fruit fly has proved to be a fruitful research subject for Bowling Green State University neuroscientist Dr. Robert Huber and colleagues from Scripps Research Institute in Florida and elsewhere. The collaborators’ research into their behavior has helped expand our understanding of some important neurobiological connections between eating and sleep — including the infamous “food coma” felt after a big meal.
Gastric bypass surgery helps severely obese teenagers lose weight and keep it off, according to the first long-term follow-up studies of teenagers who had undergone the procedure 5-12 years earlier. However, the two studies, published in The Lancet Diabetes & Endocrinology, show some patients will likely need further surgery to deal with the complications of rapid weight loss or may develop vitamin deficiencies later in life.
Scientists report in Nature using pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes. Publishing their findings online Jan. 4, researchers at Cincinnati Children’s Hospital Medical Center grew tissues from the stomach’s corpus/fundus region. The study comes two years after the same team generated the stomach’s hormone-producing region (the antrum). The discovery means investigators now can grow both parts of the human stomach to study disease.
Case Western Reserve University will host 10 booths at CES 2017 with student, faculty and alumni founders. Their new or developing technologies include: a sideline test to keep an athlete with a mild concussion off the field and out of danger from further damage, a maker machine costing less than $200 that prints hardware hacks or frosts a cake, and a pair of stuffed bears that transmit the touch of a faraway loved one.
Diners waste far less food when they’re schooled on the harm their leftovers can inflict on the environment. But if they know the food is going to be composted instead of dumped in a landfill, the educational benefit disappears.
Kevin Flanigan, MD, is the new director of the Center for Gene Therapy and the Neuromuscular Disorders program at Nationwide Children’s Hospital.
Many scientists have attempted to tackle how climate change will affect the natural world by determining the thermal tolerance of various species, then predicting what will happen to them as our world warms. However, this approach as a way to understand nature has its drawbacks because one species never acts alone, so comprehending how global change impacts these interactions is crucial to a holistic understanding.
Cincinnati Children’s researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS) – a group of pre-malignant disorders in which bone marrow does not produce enough healthy blood cells. MDS can lead to acute myeloid leukemia (AML), a fast-spreading blood cancer that can be deadly if not treated promptly.
Rebecca A. Baum, MD, will become the new chief of the Division of Developmental and Behavioral Pediatrics at Nationwide Children’s Hospital effective January 1, 2017.
Cancer researchers at the University of Cincinnati (UC) have found an obesity-associated protein’s role in leukemia development and drug response which could lead to more effective therapies for the illness.
The same researchers who pioneered the use of a quantum mechanical effect to convert heat into electricity have figured out how to make their technique work in a form more suitable to industry.
Most salamanders are homebodies when it comes to mating. But some of the beasts hit the road, traversing miles of rugged terrain unfit for an amphibian in pursuit of a partner from a far-away wetland. (With video of a salamander on a treadmill.)
In matters of international relations, size matters, according to Drs. Neal Jesse, professor of political science at Bowling Green State University, and John Dreyer, an associate professor of political science at the South Dakota School of Mines and Technology and BGSU alumnus. They are the authors of a new book on comparative foreign policy titled “Small States in the International System: At Peace and at War."
A new study of U.S. adolescents provides some of the best evidence to date of how violence spreads like a contagious disease. Researchers found that adolescents were up to 183 percent more likely to carry out some acts of violence if one of their friends had also committed the same act.
A pilot study demonstrated that with the implementation of a “local” learning health system, clinical quality can be improved while reducing health care costs. A group of 131 children treated through our Cerebral Palsy Program during the 12-month study period experienced a 43 percent reduction in total inpatient days; a 27 percent reduction in inpatient admissions; a 30 percent reduction in emergency department visits; and a 29 percent reduction in urgent care visits. LFEP Program implementation resulted in reductions in health care costs of $1.36 million. Introducing electronic health record-supported care that integrated clinical care, quality improvement and distinct, clinician-driven research resulted in large reductions in health care utilization, greatly reduced healthcare charges and improved care coordination.
Jonathan Lass, MD, has been awarded the Castroviejo Medal, the Cornea Society's highest honor. Dr. Lass, an ophthalmologist at University Hospitals Eye Institute at UH Cleveland Medical Center and Charles I Thomas Professor of Ophthalmology at Case Western Reserve University School of Medicine received the award in recognition of his lifetime contributions to research and advancements in corneal transplant and surgery.
Announcement of a new clinical trial designed to measure the impact of transcatheter aortic valve replacement (TAVR) in low surgical risk patients with severe aortic stenosis (AS).
Consumers believe healthy food must be more expensive than cheap eats and that higher-priced food is healthier – even when there is no supporting evidence, according to new research.
In the days before Hurricane Matthew, researchers used satellite maps of soil moisture to help forecast where the power would go out along the East Coast.At the American Geophysical Union meeting this week, they report that their method worked with 91 percent accuracy.
Researchers at the University of Cincinnati (UC) College of Medicine have been able to generate multifunctional RNA nanoparticles that could overcome treatment resistance in breast cancer, potentially making existing treatments more effective in these patients.
Dr. Hans Wildschutte, biology, has his eye on finding answers to the serious global issues of antibiotic resistance and novel drug discovery. The research in Wildschutte’s lab focuses on finding environmental bacteria that can kill one or multiple pathogens.
Recent years have marked a dramatic transition from paper to electronic medical records. Simultaneously, Electronic Health Record (EHR) systems allow for the creation of medical “big data”—massive collections of electronic data that can be used for medical research, public health initiatives and other health-related endeavors. To educate medical, legal, information technology and policy professionals and students about EHR systems, medical big data and the regulations that govern them, Sharona Hoffman, a professor of law and bioethics at Case Western Reserve University, wrote a new book, Electronic Health Records and Medical Big Data: Law and Policy (Cambridge University Press).
A collaboration of universities and government agencies has identified three key agricultural management plans for curtailing harmful algal blooms. They have also identified a looming funding gap for enacting those plans.
With a four-year, $2 million National Institutes of Health (NIH) grant, nurse scientists at Case Western Reserve University will conduct one of the first studies to test ways family members can maintain and improve their health while caring for relatives with bipolar disorder.
Joseph Baar, MD, PhD, Director of Breast Cancer Research at UH Seidman Cancer Center and Associate Professor at Case Western Reserve University School of Medicine, shared details about a phase II clinical trial testing the effectiveness of combining the chemotherapy drugs carboplatin and nab-paclitaxel with an immunotherapeutic agent called pembrolizumab (Keytruda) for use in patients with metastatic triple-negative breast cancer. Dr. Baar’s poster presentation was part of the Ongoing Trials-Targeted Therapy session on Dec. 8, 2016.
On July 17, more than 70 million tons of ice broke off from the Aru glacier in the mountains of western Tibet and tumbled into a valley below, taking the lives of nine nomadic yak herders living there. Researchers conducted a kind of forensic analysis of the disaster, and the cause was likely climate change.
Two new studies out of Case Western Reserve University School of Medicine describe how the inflammatory response to psoriasis can alter levels of several immune system molecules, ultimately increasing a person’s risk of thrombosis, which can include fatal blood clots
COLUMBUS, Ohio – Nothing ruins a potentially fun event like putting it on your calendar. In a series of studies, researchers found that scheduling a leisure activity like seeing a movie or taking a coffee break led people to anticipate less enjoyment and actually enjoy the event less than if the same activities were unplanned.
Researchers cracked the complete genetic code of individual cells in healthy and diseased human lung tissues to find potential new molecular targets for diagnosing and treating the lethal lung disease Idiopathic Pulmonary Fibrosis (IPF). Scientists from Cincinnati Children’s Hospital Medical Center, in collaboration with investigators at Cedars-Sinai Medical Center in Los Angeles, publish their findings Dec. 8 in the Journal of Clinical Investigation Insights (JCI Insight).
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