In Nature, a team led by U.S. Department of Energy (DOE) Joint Genome Institute (JGI) researchers uncovered a broad diversity of large and giant viruses that belong to the nucleocytoplasmic large DNA viruses (NCLDV) supergroup, expanding virus diversity in this group 10-fold from just 205 genomes.
An international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. The development marks the first engineered approach in mosquitoes that targets the four known types of dengue, improving upon previous designs that addressed single strains.
Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.
A device to quickly capture and identify various strains of virus has been developed, according to researchers at Penn State and New York University.
Researchers in China have discovered how a Zika virus protein reshapes its host cell to aid viral replication. The study, which will be published December 23 in the Journal of Cell Biology, reveals that the viral protein NS1 converts an interior cellular compartment called the endoplasmic reticulum (ER) into a protective region where the virus can survive and replicate. Blocking this process could be a novel therapeutic strategy to treat patients infected with Zika or similar viral pathogens, such as the yellow fever and dengue viruses.
The UM School of Medicine's Contract awarded by the National Institute of Allergy and Infectious Diseases could fund up to $201 Million in influenza research over seven years.
In the game against an essentially unlimited pool of virus threats, humanity is seriously outmatched. In order to shift the balance, scientists need to change the game.
Researchers at Vanderbilt University Medical Center (VUMC) are partnering with the Dutch biopharmaceutical firm Batavia Biosciences and Nashville-based IDBiologics to bring to the clinic a highly potent Zika virus neutralizing antibody they isolated three years ago.
An innovative graphene-based film helps shield people from disease-carrying mosquitos, according to a new study funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health.
Invasive mosquitoes at the northern limit of their current range are surviving conditions that are colder than those in their native territory. This new evidence of rapid local adaptation could have implications for efforts to control the spread of this invasive species.
New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.
New research suggests that 32% of children up to the age of 3 years who were exposed to the Zika virus during the mother’s pregnancy had below-average neurological development. Also, fewer than 4% of 216 children evaluated had microcephaly —a smaller-than-normal head that is one of the hallmarks of the mosquito-borne disease. The heads of two of those children grew to normal size over time, the researchers reported.
In a new study, researchers with the UF Institute of Food and Agricultural Sciences and the University of Southern Mississippi examined how quality and quantity of food ingested by the yellow fever mosquito affect its biology, including its ability to become infected by, and potentially transmit, the Zika virus.
As part of a program called the Congressionally Directed Medical Research Program, the DOD is awarding Texas Biomedical Research Institute $2 million over the next three years to study a promising experimental Zika vaccine.
Ron Trewyn, Kansas State University NBAF liaison, writes to encourage people to watch THE HOT ZONE, a National Geographic limited series inspired by two Kansas State University veterinarians and leaders and their work during the 1989 Ebola-related outbreak in Virginia.
Kansas State University researchers are helping battle most of the nation's top-priority zoonotic diseases.
In experiments with pregnant mice infected with the Zika virus, Johns Hopkins Medicine researchers report they have successfully used a long-standing immunosuppressive drug to diminish the rate of fetal deaths and birth defects in the mice’s offspring.
UF/IFAS scientists zeroed in on the Florida mosquitoes because most of the studies done on “vector competence” to date have been conducted on species in Africa and Asia.
Texas Biomedical Research Institute and UT Health San Antonio have signed an animal care and joint research agreement to move dozens of important research animals from the Sam and Ann Barshop Institute for Longevity and Aging Studies to the Southwest National Primate Research Center (SNPRC) on the Texas Biomed campus.
Researchers in Chapel Hill, N.C., and Tokyo have discovered a mechanism by which liver cells intrinsic resistance to diverse RNA viruses is regulated. These results have implications for for cellular responses to hepatitis, dengue and Zika.
New approach for delivery of DNA-encoded monoclonal antibodies (DMAbs) has been reported by Wistar scientists. This new technology allows direct production of monoclonal antibody-like molecules in living animals.
In January scientists at Vanderbilt University Medical Center (VUMC) and colleagues in Boston, Seattle and St. Louis were given an audacious goal to develop — in 90 days — a protective antibody-based treatment that potentially will stop the spread of the Zika virus.
As many as a billion people could be newly exposed to disease-carrying mosquitoes by the end of the century because of global warming, says a new study that examines temperature changes on a monthly basis across the world.
Most emerging infectious diseases affecting people are zoonotic — they make the jump from other animals to humans. Transmission, however, is a two-way street. These zoonotic diseases can also jump from humans to other animals. Even if a disease is eradicated in humans, it can live on in animals that act as reservoirs, ensuring that the risk of human infection is never entirely eradicated.
This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model.
The higher a person’s immunity to dengue virus, the lower their risk of Zika infection, an international team of scientists led by the University of Pittsburgh Graduate School of Public Health, Yale School of Public Health and University of Florida report today in the journal Science.
A collaboration of scientists including Professor Jean Patterson, Ph.D., of Texas Biomedical Research Institute, is working on a new way to detect Zika virus that will help guide clinicians in their treatment of patients with the disease. The test uses optofluidic chips to screen bodily fluids (blood, urine, semen) for the presence of the virus. This new approach will also help pinpoint the stage of the disease. Researchers at the University of California at Santa Cruz, Brigham Young University, and the University of California at Berkeley developed the technology being tested.
Scientists at Vanderbilt University Medical Center and colleagues in Boston, Seattle and St. Louis are racing to develop — in a mere 90 days — a protective antibody-based treatment that can stop the spread of the Zika virus.
With winter temperatures in Maricopa County rarely dipping below freezing--60 degrees and raining, like today, is one of its more wintry days--Arizona is a perfect home for virus-carrying mosquitoes to overwinter, allowing the virus to survive.
By age 12 to 18 months, 6.25% of children exposed to Zika during their mothers’ pregnancies had eye abnormalities, 12.2% had hearing problems, and 11.7% had severe delays in language, motor skills and/or cognitive function. In all, 14.5% had at least one of the three abnormalities.
Today, Risk Analysis, an International Journal, published a special issue, “Communicating About Zika,” which features several articles that were originally presented as works-in-progress at the Zika Communication Summit convened in March 2017 by the Annenberg Public Policy Center of the University of Pennsylvania. This special issue provides theoretical and practical insights for public health officials, risk communication researchers and risk communication practitioners, and may serve as a template for guiding and studying the dissemination of rapidly evolving health information for future and re-emerging diseases.
Researchers have generated six Zika virus antibodies that could be used to test for and possibly treat a mosquito-borne disease that has infected more than 1.5 million people worldwide, according to a study published in PLOS ONE.
In collaboration with the Houston Health Department and Epic (electronic medical records company), Houston Methodist is the first hospital system in eight U.S. pilot sites to successfully test and launch an approach to electronic case reporting (eCR) that can automatically send case reports directly from a hospital to public health agencies.
In this study, La Jolla Institute for Immunology (LJI) investigator Sujan Shresta, Ph.D., who studies both dengue and Zika viruses, explored awhether maternal immunity to Zika virus, which is structurally and genetically similar to dengue, might trigger a severe response to dengue infection in offspring.
The latest study by researchers at the La Jolla Institute for Immunology (LJI) and their collaborators provide the first in-depth characterization of the body’s cytotoxic T cell response to Zika, which plays an important role in providing protective immunity against Zika.
In an international collaboration between Sementis and Enesi Pharma, experts in the field of Zika virus and chikungunya vaccine research at UniSA’s Experimental Therapeutics Laboratory are working to evaluate a needle-free vaccination technology for SCV-based vaccines.
Thanks to an innovative mosquito control approach developed at Rutgers University–New Brunswick, residents in several Maryland neighborhoods reduced populations of invasive Asian tiger mosquitoes by an impressive 76 percent, on average. The Rutgers-led project, called Citizen Action through Science (Citizen AcTS), mobilizes neighbors guided by scientists to address local problems, according to a study in the journal Scientific Reports this week.
The NIH has given a $2.7 million R01 award to researchers at the University of North Carolina at Chapel Hill and their colleagues in Nicaragua to study maternal-fetal transmission of Zika and its impact on infant neurodevelopment.
UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection.
Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.
Researchers are reporting the protein/protein interactome of Zika virus and its human host cells with a proteomic approach that gives unprecedented insight into membrane-bound protein interactions. The data reveal a new role for a familiar organelle in viral replication.
A uniquely designed experimental vaccine against Zika virus has proven powerful in mice, new research has found.
A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.
In a new study, Barry Alto and his research group found yellow fever and Asian tiger mosquitoes – two abundant species in Florida -- can carry the Mayaro virus.
In an article published today in the journal Stem Cell Reports, Professor of Biological Science Hengli Tang and his postdoctoral researcher Jianshe Lang take a deep dive into the differences between Zika and the Dengue virus. Tang and Lang found Zika has a unique ability to ferry the virus throughout the body when most viruses would be stopped.
A collaboration between researchers at the University of North Carolina at Chapel Hill Gillings School of Global Public Health, RTI International and the UNC School of Medicine has resulted in the first study to assess and compare United States travelers’ knowledge levels about the Zika virus across three regions
A collaborative study between six of the National Primate Research Centers shows pregnancy loss due to Zika infections that don’t cause women any symptoms may be a common but unrecognized cause of miscarriages and stillbirths.
Researchers at six National Primate Research Centers (NPRCs) combined results from individual studies to find that 26 percent of pregnancies in 50 monkeys infected with Zika virus during the first trimester of pregnancy ended in miscarriage or stillbirth, dwarfing the nearly 8 percent rate found earlier this year by a study of women infected with Zika early in pregnancy.
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