Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. Now, a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found a way to attack a process that tumor cells use to escape the effects of standard cancer drugs. The discovery is published online today in the journal Nature Cell Biology.
Babson College again has been named the No. 1 business college for return on investment (ROI) for business majors, according toPayScale Inc., the world’s leading provider of on-demand compensation data and software.
Knowing the three-dimensional structures of different kinds of proteins, RNA molecules and other building blocks of the body is essential for understanding how those molecules work, what goes wrong in disease and how abnormalities might be fixed. Unfortunately, it can take years and a lot of money to determine structure using the standard experimental methods of X-ray crystallography or nuclear magnetic resonance.
Colorectal cancers heavily bedecked with tumor-related proteins called neoantigens are likely to be permeated with disease-fighting white blood cells, researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study.
A complication associated with bone marrow transplantation, graft-versus-host-disease occurs when a transplanted immune system attacks certain parts of a host’s body, and may cause severe dry eye and damage to the cornea. A clinical trial at Massachusetts Eye and Ear showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication that may cause a rise in eye pressure and other ocular complications.
New research in monkeys exposed to SIV, the animal equivalent of HIV, reveals what happens in the very earliest stages of infection, before virus is even detectable in the blood, which is a critical but difficult period to study in humans. The findings, published online today in the journal Cell, have important implications for vaccine development and other strategies to prevent infection.
A team of MIT researchers received a $300,000 grant to develop a new diagnostic program that could detect leukemia at its earliest stages.
In a paper published in the April 13 issue of Nature Communications, investigators from Harvard report on a novel biochemical method that enables the rapid and repeated regeneration of selected molecular constituents in situ after device implantation, which has the potential to substantially extend the lifetime of bioactive films without the need for device removal.
In an emerging field of research, a study in Nature Communications reveals a mechanism in the regulation of lymphangiogenesis. Scientists identified a new target for drug treatment to prevent conditions caused by lymphangiogenesis, which include some blinding eye diseases, organ transplant rejection, and cancer metastasis.
In type 1 diabetes, the immune system attacks the body’s own insulin-producing cells. Scientists understand reasonably well how this autoimmune attack progresses, but they don’t understand what triggers the attack or how to stop it, says Stephan Kissler, Ph.D., Investigator in the Section on Immunobiology at Joslin Diabetes Center and Assistant Professor of Medicine at Harvard Medical School.
Professors Mark Potter, Marjorie Feld, Ben Luippold, and Scott Taylor have been promoted at Babson College.
Longer monsoon seasons with increased daily rainfall, aspects of climate change, are contributing to reduced tea yield in regions of China, with implications for crop management and harvesting strategies, according to findings by a global interdisciplinary team led by Tufts University researchers and published online today in Climate.
Leader in Investments and Transformative Philanthropist Lulu Chow Wang ’66 to be Wellesley College’s 2016 Commencement Speaker
Researchers at Massachusetts Eye and Ear/Harvard Medical School have identified inflammatory factors that contribute to optic nerve damage following keratoprosthesis (KPro) implantation in a mouse model. They have also shown that blocking one of the factors, TNFa, leads to a significant decrease in optic nerve cell death, suggesting a new direction for preventing optic nerve damage in patients with keratoprosthesis implants.
A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study – demonstrating the test’s potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.
Eric Johnson ’72, P’08, Chief Executive Officer and President of Baldwin Richardson Food Co., known for his commitment to giving back to organizations that educate and expand opportunities for those facing economic disadvantages, will be inducted into The Babson College Alumni Entrepreneur Hall of Fame on April 13, 2016.
The Lewis Institute at Babson College will honor three entrepreneurs, each creating significant social impact through game-changing business models, with the 2016 Social Innovator Awards. This year’s recipients - Gavin Armstrong, Founder of Lucky Iron Fish™; Bernie Glassman, Founder of Greyston Bakery and the Greyston Foundation; and Bill Bolling, Founder of the Atlanta Community Food Bank - will be recognized at a campus event on April 7, 2016.
Only 15% of children achieve the recommended daily average of at least 60 minutes of moderate-to-vigorous physical activity and only 8% achieve the school-time recommendation of 30 minutes. Girls, compared to boys, had significantly fewer minutes of physical activity.
Joseph F. Rizzo III, M.D., has been awarded grant funding as part of the Vision Prosthesis Pilot Study, a Congressionally Directed Medical Research Program of the United States Department of Defense. Director of Neuro-Ophthalmology at Massachusetts Eye and Ear and the David Glendenning Cogan Professor of Ophthalmology at Harvard Medical School, Dr. Rizzo is one of three investigators to receive funding as part of the Vision Prosthesis Pilot Study Awards. His research team will use the support to develop and test a visual prosthesis to restore vision to those with severe visual impairment.
HMS graduate student and first author Hayden Schmidt describes the strange characteristics of the structure of the sigma-1 receptor, which has been linked to neurodegenerative diseases. Video: Stephanie Dutchen Sigma-1 isn’t genetically related to any other protein in the human body. It’s the adopted child of the opioid receptor family, preferring mirror image versions of the drugs that bind to “true” opioid receptors.
Understanding the motivations that drive humans to eat is an important consideration in the development of weight loss therapies. Now a study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) helps explain how the diabetes and weight loss drug liraglutide acts on brain receptors to make enticing foods seems less desirable. The findings were recently presented at ENDO 2016, the annual meeting of the Endocrine Society, and will appear in the May issue of the journal Diabetologia.
The Babson Latin American Club announced their list of speakers for the 8th annual Babson Latin American Entrepreneurship Forum on Friday, April 8, 2016. The event, this year named ‘Decision Makers’, will convene Latin American leaders and participants to share their views on entrepreneurship and business in the region.
Researchers from Massachusetts Eye and Ear and Schepens Eye Research Institute have shown an association between a defective myogenic response — the regulatory increase or decrease in blood pressure to keep blood flow within the vessels of the retina constant — and early, accelerated development of retinopathy in patients with type 1 diabetes. These findings, published online today in Investigative Ophthalmology and Visual Science, identify one mechanism to explain why some patients develop diabetic retinopathy sooner than others. Furthermore, the findings provide a target for future study, which may lead to therapies to delay or prevent the development of accelerated onset diabetic retinopathy.
The Arthur M. Blank Center for Entrepreneurship at Babson College is hosting the annual B.E.T.A. (Babson Entrepreneurial Thought and Action®) Challenge, recognizing major milestones Babson businesses have achieved by taking action.
In obesity, the body’s immune system can treat tissues as if they are suffering from a low-grade chronic infection. This obesity-induced inflammation is an important contributor to insulin resistance, a condition that can progress into type 2 diabetes.
Cancer cells are notorious for their genomes gone haywire, often yielding fusion proteins — mash-ups of two disparate genes that, once united, assume new and harmful capabilities. Exactly how such genome scrambling impacts RNA, particularly the vast and mysterious world of non-coding RNA, has been largely unexplored. Now, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) offers some early answers by studying an intriguing class of non-coding RNAs known as circular RNAs.
Babson College announces the appointment of Michael D. Johnson as provost. Johnson comes to Babson from the School of Hotel Administration at Cornell University, where he is the Bradley H. Stone Dean and E.M. Statler Professor.
Massachusetts Eye and Ear has awarded five research grants through the Curing Kids Fund to support projects aimed at advancing treatments for pediatric diseases related to the institution’s areas of expertise.
Scott A. Armstrong, MD, PhD, an internationally renowned pediatric hematologist/oncologist, has been named Chair of the Department of Pediatric Oncology at the Dana-Farber Cancer Institute, and the David G. Nathan Professor of Pediatrics at the Dana-Farber Cancer Institute, Boston Children’s Hospital, and Harvard Medical School.
Assistant professor Javier Apfeld plumbs the cellular mechanisms driving the aging process in worms, uncovering insights that could increase our own longevity.
Nearly 1 million people in the United States receive coronary artery stents each year. Nearly all stent patients are expected to take dual antiplatelet therapy (DAPT) using the combination of aspirin and a second antiplatelet medication to prevent the formation of blood clots. Exactly how long patients should receive DAPT has been debatable.
Through an agreement with City Year, Fellows in the Tufts 1+4 Bridge-Year Service Learning program will now be able to serve in urban school districts in the U.S. Tufts 1+4 offers accepted applicants the chance to learn from a year of service before starting as undergraduates at Tufts. This is City Year's first formal relationship with a university bridge-year program.
Linda Carli's "Stereotypes About Gender and Science: Women ≠ Science” shows that despite significant progress made, women are still thought to lack the qualities needed to be successful scientists, and the findings suggest this may contribute to discrimination and prejudice against women in those fields.
Analyses across metropolitan Boston show the need for better detection of natural gas emissions.
Pancreatic cancer, the fourth leading cause of cancer death in the United States, is often diagnosed at a late stage, when curative treatment is no longer possible. A team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has now identified and validated an accurate 5-gene classifier for discriminating early pancreatic cancer from non-malignant tissue. Described online in the journal Oncotarget, the finding is a promising advance in the fight against this typically fatal disease.
An outbreak of multidrug resistant tuberculosis (MDR-TB) in Papua New Guinea may well become a replay of the disastrously delayed response to the West African Ebola pandemic, says Jennifer Furin, Harvard Medical School lecturer on global health and social medicine, in a commentary she co-authored with Helen Cox, senior lecturer in the Division of Medical Microbiology at the University of Cape Town, South Africa.
The Wellesley College Concert Series hosts global superstar Wu Man on campus in April to perform with the Shanghai Quartet, one of the foremost chamber music ensembles in the world. The concert features the ancient Chinese pipa instrument and blends East and West.
The Babson Energy and Environment Club will host its 10th Annual Babson Energy and Environment Conference on Friday, April 1st at Babson College.
The horrific bombings in Brussels on Monday morning killed dozens and injured hundreds at the city’s airport and a train station, leaving another European nation reeling after a terrorist attack and generating more questions about the ongoing fight against terrorism.
Tufts University School of Medicine Match Day 2016 included our fourth cohort of Maine Track MD students. The Maine Track MD program is a partnership between Tufts University and Maine Medical Center.
Babson College will host the first-ever Babson India Symposium on April 16, 2016. The new event will provide a stage for global business leaders, entrepreneurs, and academicians alike to share in their experiences about India’s emergent business world, burgeoning opportunities, and how to further unlock the country’s potential.
Promising research from Tufts University's School of Engineering has earned one faculty member the prestigious Presidential Early Career Award and two faculty members Faculty Early Career Development (CAREER) awards from the National Science Foundation (NSF) and U.S. Department of Energy.
Two Olin College professors have launched a website focused on making DIY tools accessible to help people with disabilities perform daily tasks and, along the way, offer a more expansive view of the Maker movement. Since its launch the site has touched a chord among educators and the medical and adaptive technology community, resulting in more than 7,000 visitors—and many more thousands of page views—in just the first few weeks.
Harvard Medical School graduate student Thomas Graham explains the techniques he used to peer into how DNA double-strand breaks are repaired. Video: Stephanie Dutchen Dozens of times per day in each of the trillions of dividing cells in our bodies, the double strands that form our DNA may break and need to be fixed. Harvard Medical School scientists have now devised a way to watch how these essential repairs get made in real time and at previously unattainable resolution, allowing them to discover individual steps in the repair process and identify which proteins are involved in each.
Our brains are marvels of connectivity, packed with cells that continually communicate with one another. This communication occurs across synapses, the transit points where chemicals called neurotransmitters leap from one neuron to another, allowing us to think, to learn and to remember. Researchers have known that these synapses often need a boost to send information across neuronal divides.
Scientists from Beth Israel Deaconess Medical Center show that PGC1 alpha works through the NAD "aging molecule" to guard against stress; research offers new therapeutic target for acute kidney injury, a widespread problem for hospitalized patients
Tumors induced by oncogenes can be both prevented and normalized using light to control electric signaling among cells. The findings in frogs extend the application of optogenetics from neurons and the brain to cancer and provide proof of principle for a novel class of therapies which use light to override the action of oncogenic mutations.
Dana-Farber Cancer Institute researchers are leading a multicenter genetic study of prostate cancer in Sub-Saharan Africa to try to find new information about the genetic etiology of prostate cancer.
Olin College of Engineering and North Hill, a senior living community in Needham, Mass., announce the third annual North Hill-Olin College Fund for Innovation in Aging event to be held Tuesday, April 12, 2016, at Olin College from 5:00 pm-8:00 pm. The event is free and open to the public.
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