Dartmouth investigators point to the shortcomings of using the word stress in a medical or scientific context and encourage bodymind therapies to treat trauma in patients with cancer.
Dartmouth researchers identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease.
Dartmouth study finds some portions of the female reproductive tract are more likely to be infected by HIV, particularly the ectocervix compared to the endometrium.
A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.
Uncovering cellular response to stress may provide leverage to determine how to trick undesirable cells, such as cancer or damaged cells, into dying instead of recovering from stress.
The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations.
By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus.
The mechanism that makes fireflies glow through a process called bioluminescence can be used to study tumor response to therapy as well, researchers have found.
Taking the focus off pain management and specific post-treatment symptoms, Norris Cotton Cancer Center researchers establish a new paradigm for working with breast cancer survivors
Though the Academy of Pediatrics advises against the consumption of energy drinks by teens, research finds that manufacturers market the bulk of their products on TV channels that likely appeal to teens.
Researchers have identified a new source of methane for gas hydrates — ice-like substances that trap methane within the crystal structure of frozen water — in the Arctic Ocean. The findings point to a previously undiscovered, stable reservoir for methane that is “locked” away from the atmosphere, where it could impact global climate change.
The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Norris Cotton Cancer Center (NCCC) at Dartmouth, continuing NCCC's designation as a Comprehensive Cancer Center.
Dartmouth team uses nanomaterials to pursue a systematic study of variables in xenograft models of both breast and ovarian human cancer.
Dartmouth bioengineers demonstrate a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells.
Investigators from Dartmouth's Norris Cotton Cancer Center find that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division.
Research finds the values measured with dynamic contrast enhanced computer tomography strongly correlated with fluorescence intensity measured directly from the pancreatic tissue.
Utilizing a novel transgenic mouse model, Edward Usherwood, PhD of Dartmouth's Norris Cotton Cancer Center and collaborators found that CD4 T cells divide into two different populations that each has a different job.
Elissa Ozanne, PhD from Dartmouth's Norris Cotton Cancer Center and colleagues concluded that mobile health devices are acceptable to older, diverse, and low income women.
While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ).
The benefits of these findings are directly applicable to other reproductive challenges including gynecological cancers such as cervical cancer.
Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found.
Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries.
The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective.
Study determines if follicle stimulating hormone and estrogen at the upper limits of normal could predict treatment success as measured in live birth rates.
Chemicals used as synthetic flame retardants that are found in common household items such as couches, carpet padding, and electronics have been found to cause metabolic and liver problems that can lead to insulin resistance, which is a major cause of obesity, according to new research from the University of New Hampshire.
While methods for identifying immunogenic hotspots, or epitopes, are evolving rapidly, technologies to redesign the hotspots while maintaining biotherapeutic activity and stability are far less developed.
Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials.
A collaborative national clinical trials group discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought.
In a study of 10 large health systems, researchers at Dartmouth and the University of Michigan found that implementation of pilot accountable care organizations (ACOs) did not limit spending on discretionary or non-discretionary cardiovascular treatment for patients.
Dartmouth investigators note the lack of hypothesized scientific models for the mechanisms of action responsible for outcomes in Somatic Experiencing(SE) trauma therapy and other body-mind therapies.
A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found.
Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found.
Three papers in the survival monograph published by the Journal of the National Cancer Institute, co-authored by Dartmouth's Norris Cotton Cancer Center investigators Steven Woloshin, MD, MS, and Lisa Schwartz, MD, MS, aim to help doctors, patients, and policymakers better understand cancer prognosis and survival.
In the search for new approaches to treat ERBB2 positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism.
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform.
) Using a simple camera and water tank, investigators from Dartmouth-Hitchcock’s Norris Cotton Cancer Center demonstrated that induced Cherenkov light can be imaged and used to confirm that the complex spatial dose distribution imparted in dynamic treatment plans is being delivered correctly.
Researchers report on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties.
While not superior to capecitabine, eribulin is an active and well-tolerated therapy in women with metastatic breast cancer (MBC) receiving this therapy as a first, second, or third line chemotherapy regimen.
By implementing a “best practice alert” function in the electronic medical record, pathologists at Dartmouth-Hitchcock significantly reduced physicians’ orders for two-unit transfusions for non-bleeding patients.
Cancer fighting chimeric antigen receptor (CAR) T cells, developed in the Sentman laboratory of Dartmouth’s Norris Cotton Cancer Center, are taking the next step into a Phase I clinical trial beginning early in 2015.
Substantial improvements were seen in control of hypertension and cholesterol, and smoking cessation, according to a study in the January 13 issue of JAMA.
Partnering with head and neck surgeons, pathologists at Dartmouth Hitchcock Medical Center's Norris Cotton Cancer Center developed a new use for an old test to determine if a patient's cancer is recurring, or if the biopsy shows benign inflammation of mucosal tissues.
By looking at the expression levels of downstream genes of the regulators in breast cancer, investigators have identified a gene signature in E2F4 that is predictive of estrogen receptor positive (ER+) breast cancer.
By developing cell lines that grow readily in culture, investigators have created a fast-track research tool that remains applicable to many scientists who use mouse melanoma as a model system.
Researchers at the Norris Cotton Cancer Center and University of Hawaii Cancer Center find that one-third of Hawaiian adolescents have tried e-cigarettes, half of whom have never used another tobacco product.
Apheresis, the simple process of drawing blood, becomes a powerful therapeutic in extracorporeal photopherisis (ECP) according to clinicians and scientists who met at the NIH State of the Science Symposium in Therapeutic Apheresis.
The fruits and vegetables provided at school deliver an important dietary boost to low income adolescents, according to Meghan Longacre, PhD and Madeline Dalton, PhD of Dartmouth Hitchcock’s Norris Cotton Cancer Center and The Hood Center for Children and Families
Supplemental ultrasound screening for all U.S. women with dense breasts would substantially increase healthcare costs with little improvement in overall health, according to senior author Anna Tosteson, ScD, at Dartmouth Hitchcock’s Norris Cotton Cancer Center and The Dartmouth Institute for Health Policy and Clinical Practice.
A team of researchers at Dartmouth College and University of Pittsburgh found respondents who had smoked water pipe tobacco but not smoked cigarettes were at increased risk of cigarette smoking two years later as recently published online in JAMA Pediatrics.
Environmentalists dispirited by the Republicans’ dominance of the recent midterm elections can take heart: non-Tea Party Republicans’ views on science and environmental issues are closer to those of Independents than to Tea Party supporters. That’s the primary finding of new research published this week in the journal Environmental Politics.
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