In testing GARDASIL reduced abnormal Pap test results by 43 percent compared to women not given the vaccine, according new research. The findings show the approved anti-HPV agent appears to prevent the development of cell changes that lead to cervical disease, said a researcher at the University of Alabama at Birmingham (UAB). The results were presented at a conference Monday in Tampa.
A new study from U-M C.S. Mott Children's Hospital finds that using risk factors "“ including a woman's sexual history - to target specific populations for HPV vaccination is not effective, and would exclude as many as 80 percent of women who could benefit the most from the vaccine.
A new vaccine design strategy developed by scientists at The Wistar Institute could help to develop vaccines against diseases like AIDS and cervical cancer. The secret is using a herpes simplex protein called glycoprotein D to block a receptor molecule on antigen-presenting cells.
A vaccine not yet licensed in the United States produces immunity against four strains of meningococcal disease and is well tolerated when administered to infants, according to a study in the January 9/16 issue of JAMA.
Leading efforts to create an HIV vaccine have hinged on the use of viruses as carriers for selected elements of the HIV virus. Recently, however, evidence has emerged that some of these so-called viral vector systems may undermine the immune system and should not be used for vaccine development. Now, a new study from scientists at The Wistar Institute provides strong support for the idea that some viral-vector vaccines may cause more harm than good.
Among patients hospitalized with community-acquired pneumonia, those who had previously received the pneumococcal vaccine had a lower risk of death and admission to the intensive care unit than patients who were not vaccinated, according to a report in the Oct. 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Flu vaccine delivered through painless microneedles in patches applied to the skin could soon be an alternative to delivery through hypodermic needles, according to researchers at Emory University and the Georgia Institute of Technology in Atlanta.
Cancer and HIV vaccine researchers from around the world will gather for a three-day conference in New York City October 4-6, 2007, along with representatives from industry and health research funding organizations to share and discuss data from the latest clinical and laboratory studies aimed at developing preventive and therapeutic vaccines for both diseases.
Childhood vaccination for the rubella virus may have also almost entirely eliminated an inflammatory eye disease from the U.S.-born population, according to a study by researchers at the University of Illinois at Chicago.
The human papillomavirus (HPV) has been implicated as a cause of cervical cancer in women, but there's another devastating form of cancer also linked to HPV infection "” head and neck cancer "” and almost no one is talking about it.
Researchers have identified a sugar in mosquitoes that allows the malaria parasite to attach itself to the mosquito's gut. Invasion of the midgut cell layer is an essential stage in the parasite's lifecycle and malaria transmission. Reducing the level of the sugar in the mosquito prevented 95% of the parasites in the mosquito from attaching to the gut.
A promising new HIV vaccine created at The Wistar Institute has received funding for clinical development aimed at moving the vaccine into human clinical trials as soon as possible. With $13.3 million in funding over five years starting September 1, the planned trials will be conducted under the auspices of the Integrated Preclinical/Clinical AIDS Vaccine Development Program of the National Institute of Allergy and Infectious Diseases.
A unique mouse provides the first animal model for dengue fever, enabling tests of antiviral therapies. Now the model is being further developed so it can be used to test vaccines against this mosquito-borne disease.
A new study shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease. The researchers created a vaccine in mice that suppresses aggregates of tau. The protein accumulates into harmful tangles in the memory center of the brains of Alzheimer's patients.
A nasal vaccine showed strong promise in initial animal studies. University of Michigan scientists say the result could be a better anthrax vaccine that requires no shots, is effective with only one or two immunizations, needs no refrigeration and could be used effectively after a bioterrorism attack to boost immune response in exposed people.
For women with human papillomavirus (HPV) infection, use of the HPV-16/18 vaccine will not accelerate reduction of the virus and should not be used to treat the infection, according to a study in the August 15 issue of JAMA.
New research conducted at the Uniformed Services University of the Health Sciences (USU) suggests that it may be possible to develop a vaccine that protects against the myriad strains of the HIV virus. HIV is extremely variable, so an effective vaccine may need to stimulate the body to produce cross-reactive antibodies that will neutralize multiple viral strains. These results demonstrate that induction of truly broad-spectrum neutralizing antibodies may be an achievable goal.
The Wistar Institute will announce the establishment of the Wistar Institute Vaccine Center. Extending Wistar's history of accomplishment in vaccine development, the new center will focus the Institute's scientific strengths in immunology, virology, and other research disciplines on creating new or improved vaccines against some of the most dangerous and widespread diseases in the world: HIV, influenza, rabies, hepatitis C, malaria, and others.
A new report released by the U-M C.S. Mott Children's Hospital National Poll on Children's Health finds the majority of U.S. parents do not support school mandates for Gardasil, the vaccine designed to protect against HPV. Only 44 percent of parents are in favor of a school mandate for the HPV vaccine.
A thin strip that dissolves in the mouth like a popular breath-freshener could someday provide life-saving rotavirus vaccine to infants in impoverished areas. The innovative drug-delivery system was developed by undergraduate biomedical engineering students.
An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 "“ May 5, 2007. Prion diseases, which include scrapie, mad cow disease, and chronic wasting disease, are fatal and there is no treatment or cure.
Today at the 2007 Annual Meeting of the American Association for Cancer Research, presentations on ongoing HPV trials and other new approaches to stimulating the immune system are injecting momentum into cancer vaccine research.
Experimental vaccines to help the immune system fight tumors have rarely been designed to directly stimulate helper T cells, one of the body's most critical immune responders, because of the difficult process required to isolate and clone antigens for vaccine development. Now, a new technique may allow scientists to create a melanoma vaccine able to stimulate helper T cells.
Smallpox was eradicated in 1980, but the virus still exists in WHO controlled depositories. In this week's BMJ, two experts go head to head over whether these stocks should be destroyed.
An influenza vaccine produced with the use of insect cells appeared safe and produced an immunogenic response in healthy adults, suggesting promise as an alternative to using embryonated eggs for the development of influenza vaccine, according to a preliminary study in the April 11 issue of JAMA.
The American Academy of Pediatrics (AAP) is alarmed that the soaring costs of vaccines combined with lower reimbursements from insurance companies will lead to the under-immunization of the nation's children and unnecessary outbreaks of preventable diseases.
Routine infant immunization with pneumococcal conjugate vaccine (PCV7) has caused a 39 percent fall in all-cause pneumonia hospital admission rates for American children under 2, according to an article published in this week's edition of The Lancet.
One of the persistent riddles of the deadly 1918 Spanish influenza pandemic is why it struck different cities with varying severity. Why were some municipalities such as St. Louis spared the fate of the hard-hit cities like Philadelphia when both implemented similar public health measures? What made the difference, according to two independent studies.
Infectious diseases researchers are seeking healthy adults to help test a vaccine for malaria. While malaria is no longer considered a threat within U.S. borders, according to the World Health Organization (WHO), the disease kills more than 1 million people around the globe each year. Most of its victims are children.
Data from a national study suggests that about one in four U.S. females between the ages of 14 and 59 years may have the sexually transmitted infection human papillomavirus (HPV), according to a study in the February 28 issue of JAMA.
The University of Texas at San Antonio and The University of Texas Health Science Center at San Antonio researchers are working to discover a vaccine to prevent Chlamydia--the most common bacteria-related sexually transmitted disease in the United States.
Leading physician and advocacy organizations from across the health care spectrum join together to ensure the United States is prepared to deliver on a major women's health breakthrough -- the elimination of most forms of cervical cancer through access to new vaccines and screening.
The Blueprint includes an assessment of vaccine candidates in the pipeline; highlights key scientific obstacles to the discovery and development of a preventive HIV vaccine; addresses financial and political challenges that are impeding the AIDS vaccine search; and provides new recommendations for overcoming these challenges.
As more and more promising results of clinical trials on vaccination against human papillomaviruses are published, the more likely it becomes that an HPV vaccine will be the first licensed immunization against a sexually transmitted disease.
A UK study provides further evidence that measles-mumps-rubella (MMR) immunisation is not associated with the development of autism or other pervasive developmental disorders (PDDs) in children.
Paul A. Offit, M.D., will discuss "Science, Politics and the Media" at the AAAS Vaccine Seminar. He will discuss how scientists convey their findings to the public, citing the case of the alleged link between the measles vaccine and autism.
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