Focus: Hidden - Alabama

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Global climate trend since Dec. 1 1978: +0.13 C per decade

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• The ultimate goal of basic biomedical research is to better the lives of patients through prevention, control or cure of disease. • Crossing that gap between the lab and bedside is difficult to achieve. • One great need for better treatment is diabetes, a disorder that afflicts one of every 10 U.S. adults and doubles the risk of early death.

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Verapamil, a widely used blood pressure medication, has been found to help promote insulin production in adult subjects with recent-onset Type 1 diabetes by preserving beta cell function, when added to a standard insulin regimen. The findings mark the first effective, non-immunosuppressive therapeutic approach discovered to help target loss of beta cell function in Type 1 diabetes.

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A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children’s of Alabama.

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In a large-scale analysis, Jeremy Blackburn, Ph.D., and collaborators found that the misuse of web archive services causes loss of ad revenue for popular news websites.

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Researchers have shown — for the first time — that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. This is important because, despite significant advances in the pathological mechanisms of persistent fibrosis, effective interventions are lacking.

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Researchers in the School of Public Health are conducting a clinical trial to see whether psilocybin, the active compound found in Psilocybe mushrooms, will help individuals addicted to cocaine stop using the harmful drug.

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Written by: Haley Herfurth Media contact: Adam Pope, [email protected] Wolfgang Muhlhofer, M.D.Status epilepticus, a dangerous condition in which epileptic seizures follow one another for a duration of five or more minutes without the victim’s regaining consciousness between them, is the second most common neurological emergency in the United States, with a recorded maximum of around 150,000-plus cases per year.

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Researchers in the School of Public Health are conducting a clinical trial to see whether psilocybin, the active compound found in Psilocybe mushrooms, will help individuals addicted to cocaine stop using the harmful drug.

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In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn’s disease and ulcerative colitis.

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A disease-inducing fungus in amphibians worldwide could become deadlier as different genetic variations emerge, according to research led by The University of Alabama.

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A surprising event promotes global changes in glioblastoma. Dying, apoptotic cancer cells release extracellular vesicles that carry components to alter RNA splicing in the recipient glioblastoma cells, and this increases their aggressiveness, motility, and resistance to radiation or chemotherapy.

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Valerie Powell credits her career shift from marketing to medicine as the turning point that saved her life.

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UAH SMAP Center student interns have created a variety of cost-effective 3-D printed task trainers to be used by students in UAH’s College of Nursing.

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Assistant professor Dr. M. Tauhidur Rahman, Ph.D. students Sadman Sakib and Preeti Kumari, assistant professor Dr. Biswajit Ray, and Ph.D. student M.S. Bahar Talukder, all of UAH’s Department of Electrical and Computer Engineering, have developed a novel method of detecting counterfeit flash memory with close to 100 percent confidence using program-erase time.

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Kazutoshi (Kazu) Nakazawa, M.D., Ph.D., whose work has explored how abnormalities in brain circuitry can trigger complex mental disorders, has joined the Southern Research's Neuroscience Department as a Fellow.

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Systems biology was used to identify previously unknown protein targets of plant pathogens in Arabidopsis thaliana, employing some of the same methods used to analyze social networks. This theoretical framework could help analyze other interactions between species to reveal pathogen contact points.

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Global climate trend since Dec. 1 1978: +0.13 C per decade

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For decades, oxidative stress was linked to heart failure. Now in a clinical study, researchers find that a subgroup of heart failure patients have a hyper-reductive state, called reductive stress. Thus, the subgroup may benefit from personalized antioxidant therapies.

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Melanoma is highly capable of spreading and can be deadly rapidly if not treated.

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UAB economists show the benefits of gun purchase delay policy in relation to suicide rates.

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A UAB researcher is heading to Cameroon to study the effects and safety of antibiotics on pregnant women at risk of contracting malaria.

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A new study compared EMS use of endotracheal intubation versus a laryngeal tube for patients with out-of-hospital cardiac arrest. Results indicate increased survival rates with use of the laryngeal tube.

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The clinical trial attempts to persistently lower the serum uric acid level in patients.

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The UAB-led clinical trial intends to provide multiple myeloma patients a treatment plan that eradicates their disease and enables them to live a life without ongoing treatment.

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Preclinical and early clinical research conducted by teams at the University of Alabama at Birmingham and in Australia suggests that patients with rheumatoid arthritis could lower their risk of cardiovascular disease through cholesterol-lowering therapies.

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Researchers describe changes in hippocampal neurons early after pathogenic alpha-synuclein aggregates begin to appear. This understanding could point to novel therapeutic treatments to prevent or reverse neuronal defects and halt development of dementia.

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Chronic inflammatory diseases such as cardiovascular disease, diabetes, obesity, cancer and lupus have their highest U.S. concentrations in the Southeast. Yet, says Fran Lund, the majority of clinical trials to test possible new treatments for these diseases occur outside of the Southeast.

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UAB Medicine has a new app to help patients and visitors navigate its large campus. The app offers turn by turn wayfinding to clinics, hospital units, nearby restaurants and much more.

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• This study was the first to test a form of intermittent fasting, known as early time-restricted feeding, in humans. • The study shows for the first time in humans that the benefits of intermittent fasting are not due solely to eating less. • Practicing intermittent fasting has intrinsic benefits regardless of what you eat.

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Since 1968, UAB Medicine has performed more than 14,000 life-saving organ transplants.

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Southern Research’s Prosperity Fund is assisting an Alabama startup that sees one of nature’s great recyclers – the black soldier fly – as an instrument to convert chicken poop into high-value products such as protein-rich animal feed and organic fertilizer.

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Hair’s graying is linked to innate immune response, activation of which can decrease pigmentation in hair.

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Global climate trend since Nov. 16, 1978: +0.13 C per decade

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Medicare and Medicaid beneficiaries with end-stage heart failure seeking OHT and LVAD implantation will be drastically affected if the proposed cuts are implemented, according to UAB research.

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More than a century after John Stuart Mill’s personal library was donated to an Oxford college, a University of Alabama English professor and a team of international collaborators are allowing a broader audience access to the history literally hand-written by Mill into the margins of his books.

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A paper by UAH physics professor Dr. Don Gregory and UAH Ph.D. student Seyed Sadreddin Mirshafieyan was recently published in "Nature, Scientific Reports."

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Dr. Matthew Niemiller, an assistant professor of ecology at UAH, conducts field research in caves throughout the Tennessee Valley and around the country to better understand species that are rare, threatened, endangered, or relatively unknown.

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An alternative treatment option to the glucocorticoid-induced bone loss that can cause fractures now appears promising, according to an international study. Researchers compared the monoclonal antibody denosumab against a standard bisphosphonate treatment.

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Riding bicycles is a fun and healthy way to get around efficiently. Know the rules and keep yourself safe while riding.