Focus: Cancer Center Featured Story 2

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The American Cancer Society estimates more than 95,000 Americans will be diagnosed with colon cancer this year. Dr. Charles Fuchs at Yale Cancer Center discusses way to prevent the disease.

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The vaccine for HPV is proving to have significant population-level effects in Connecticut, a new Yale School of Public Health study finds.

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Moffitt researchers have developed a test called the radiosensitivity index that determines how sensitive a patient’s tumor is to radiation therapy. The radiosensitivity index is based on the expression of different genes in a patient’s tumor and has been validated in 9 different patient groups across different tumor types.

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New Collaboration Will Grant CancerLinQ Subscribers Streamlined Access to the NCCN Compendium®

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Ludwig Cancer Research released today the full scope of Ludwig’s participation at this year’s American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, June 2-6.

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Combo of T-cell therapy, newly FDA-approved drug and another immunotherapeutic agent kept cancer at bay for three out of four patients with metastatic Merkel cell carcinoma. The findings will be presented June 5 at the annual meeting of the American Society of Clinical Oncology.

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As many as 53 percent of cancer patients’ Emergency Department visits that do not require admission could be avoided with better symptom management and greater availability of outpatient care tailored to their needs, according to a new study from Fred Hutchinson Cancer Research Center. This study will be presented at the 2017 American Society for Clinical Oncology meeting on June 5, 2017. It is Abstract #6505 (link here: http://abstracts.asco.org/199/AbstView_199_193735.html).

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These studies were funded through a collaboration with AstraZeneca to evaluate the effectiveness of osimertinib in EGFRm+ non-small cell lung cancer

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Every animal starts as a clump of cells, which over time multiply and mature into many different types of cells, tissues, and organs. This is fundamental biology. Yet, the details of this process remain largely mysterious. Now, scientists have begun to unravel an important part of that mystery.

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All cancer tumors have one thing in common – they must feed themselves to grow and spread, a difficult feat since they are usually in a tumor microenvironment with limited nutrients and oxygen. A study at The University of Texas MD Anderson Cancer Center has revealed new details about how an enzyme called acetyl-CoA synthetase 2 (ACSS2) allows brain tumors to grow despite their harsh surroundings.

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Funding announcement from the Ontario Institute for Cancer Research

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A study from Fred Hutchinson Cancer Research Center that will be presented at the American Society of Clinical Oncology annual meeting on June 5 in Chicago shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.

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A new study led by researchers at Roswell Park Cancer Institute establishes a connection between a sedentary lifestyle and risk of developing kidney or bladder cancer.

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The University of Kansas Cancer Center joins Blood Cancer Research Partnership

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A Yale research team has found that by tinkering with the surface properties of drug-loaded nanoparticles, they can potentially direct these particles to specific cells in the brain.

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Researchers in the Integrated Mathematical Oncology Department at Moffitt Cancer Center recent study found that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

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On May 31, 1-2 p.m. (CDT), The University of Kansas Cancer Center and Children’s Mercy Hospital will co-host an online discussion, via Twitter, about changing the way healthcare providers treat tobacco dependence.

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Plans to cut nearly $8.2 billion from the National Institutes of Health, including a $1 billion reduction for the National Cancer Institute, would decimate cancer research and patient care, according to the Association of American Cancer Institutes.

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data from four early-phase immunotherapy combination trials will be presented at the American Society for Clinical Oncology (ASCO) Annual meeting in Chicago on June 5, 2017.

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Drinking just one glass of wine or other alcoholic drink a day increases breast cancer risk, finds a major new report by the American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF).

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NCCN and Pfizer seek grant proposals for use of clinical care pathways aimed at quality improvement along the continuum of care for patients with breast cancer.

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Moffitt Cancer Center moved up two spots to be the No. 4 ranked health care facility on DiversityInc’s 2017 Top Hospitals & Health Systems list. Moffitt is the only cancer center and the only Florida health institution on the specialty list. DiversityInc announced the ranking during its diversity and inclusion keystone event May 2 at Cipriani Wall Street in New York.

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A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient’s cancer biopsy varied by age and the type of cancer, along with several other factors.

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A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

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Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

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Improvements in chemotherapy and liver surgery have resulted in increased overall survival in patients with advanced stage colorectal cancer in recent decades. In order to better predict outcomes for these patients, researchers at Rutgers Cancer Institute of New Jersey conducted a retrospective analysis and found that stage IV colorectal cancer patients who survived at least two years have a better prognosis than originally thought.

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While gemcitabine and brentuximab vedotin each have benefit when given individually in the treatment of Hodgkin lymphoma, Investigators from the Children’s Oncology Group including a Rutgers Cancer Institute of New Jersey physician-scientist examined the two therapies when combined in pediatric patients. They found the combination to be safe and to have a greater complete response rate than when the drugs are given individually.

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Colon cancer patients who have a healthy body weight, exercise regularly and eat a diet high in whole grains, fruits and vegetables have a significantly lower risk of cancer recurrence or death, according to a research team led by UC San Francisco investigators. This finding represents an analysis of data collected on patients participating in a national study for people with stage III colon cancer.

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Younger women may face higher costs for breast cancer care than older patients at least in part because they're diagnosed when tumors are more advanced and require more aggressive treatment, a recent U.S. study suggests.

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African Americans and other minorities are at a higher risk for certain types of cancer, yet they continue to be underrepresented in clinical trials for drugs approved by the U.S. Food and Drug Administration.

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A new study by researchers at Yale School of Medicine and Johns Hopkins School of Medicine has found that surgeons’ use of a new imaging test is influenced by the practice style of their peers.

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FDA approves brigatinib as a second-line therapy for ALK-positive non-small cell lung cancer

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A University of Colorado Cancer Center clinical trial is now recruiting prostate cancer patients who would otherwise be on a watch-and-wait protocol to test the ability of grape seed extract to slow the rise of prostate-specific antigen (PSA), a common marker of prostate cancer progression.

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An interim analysis of a phase I clinical trial examining a surgical procedure to remove the prostate and prostate cancer in men whose disease has spread (metastatic) shows the operation is safe and feasible in carefully selected patients.

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Patients with castration resistant prostate cancer (CRPC) usually have a poor prognosis. In part, this is due to the cancer’s ability to resist anti-androgen therapy. A University of Colorado Cancer Center study published today [May 3] in Oncotarget shows that combining a CPT1A inhibitors with anti-androgen therapy increases the cancer’s sensitivity to the anti-androgen drug enzalutamide.

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The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM). Now, Ludwig researchers have shown that one way to override the growth-promoting effects of PTEN deletion is, surprisingly, to inhibit a separate tumor suppressor gene.

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As published in JNCCN – Journal of the National Comprehensive Cancer Network, a Gundersen Health System study found that most patients look for guidance on physical activity during cancer care, but oncologists do not feel equipped to give recommendations.

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Seattle Cancer Care Alliance experts are available to discuss new U.S. Preventive Services Task Force guidelines related to thyroid cancer screening for adults, risk factors and treatment options.

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Mothers infected with malaria during pregnancy can pass more of their own cells to their baby and change the infant’s risk of later infection, a new study shows.

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The free Art of the Scarf workshop to teaches women how to tie, wrap or twist scarves for headwear. The workshop at The UNM Cancer Center is open to all patients, survivors with long-term hair loss, and caregivers. It is offered free of charge but reservations are required.

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Blavatnik fund to speed discoveries to patients

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Memorial Sloan Kettering (MSK) has reached a major milestone in bringing personalized treatments to more cancer patients. Michael Berger, PhD, Ahmet Zehir, PhD, and colleagues have reported an in-depth analysis of the first 10,336 patients whose tumors were submitted for clinical genomic sequencing by MSK-IMPACT™, a powerful diagnostic test developed at MSK to provide detailed genetic information about a patient’s cancer.

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The University of Texas MD Anderson Cancer Center named eight innovative researchers to the second annual class of Andrew Sabin Family Fellows at a luncheon today attended by Andrew Sabin, of East Hampton, New York, and representatives of the Andrew Sabin Family Foundation. The Andrew Sabin Family Fellowship Program provides $100,000 in funding per fellow over two years through a $30 million endowed gift to encourage research creativity, independent thinking and high-impact cancer research.

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The eighth annual “Polly’s Run” raises awareness for pancreatic cancer, honors pancreatic cancer survivors and all those who face the disease, and raises money for pancreatic cancer research. Albuquerque Pet Memorial Services sponsors the event. All proceeds benefit The University of New Mexico Comprehensive Cancer Center.

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A new meta-analysis by a team from Roswell Park Cancer Institute demonstrates that Enhanced Recovery After Surgery (ERAS) programs are effective in patients requiring many abdominal and pelvic operations, not just those undergoing colorectal surgeries.

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A targeted drug whose clinical testing was led by Richard Stone, MD, of Dana-Farber Cancer Institute, has become the first new treatment for newly diagnosed acute myeloid leukemia (AML) in more than 25 years.

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Machine learning (or coding) could help reduce false positives from mammography screening, according to an article study published online in the May 4, 2017 issue of the Journal of the American Medical Association (JAMA) Oncology. The national coding competition known as the DREAM Challenge, launched during the inauguration of Vice President Biden’s Cancer Moonshot Challenge, may help mitigate this harm associated with routine screening.