DARA BioSciences' diabetes medication DB959 achieves positive results in first clinical trial; drug is well-tolerated with possibility for once-daily oral dosing; results presented at ADA.
Excess nutrients, such as fat and sugar, don’t just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this “toxic” environment, these cells commit suicide. Now, scientists at Washington University School of Medicine in St. Louis have discovered three unexpected players that help a cell overloaded with fat initiate its own demise.
In type 2 diabetes, a protein called amylin forms dense clumps that shut down insulin-producing cells, wreaking havoc on the control of blood sugar. But zinc has a knack for preventing amylin from misbehaving.
A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that early, prolonged treatment with the diabetes drug metformin may prevent or delay the development of polycystic ovary syndrome (PCOS) in adolescence.
A computer-based diabetes simulation tool developed by University of Virginia researchers is now commercially available, thanks to a partnership with Charlottesville-based medical research firm The Epsilon Group. The protocol is approved by the FDA as an alternative to animal testing of Type 1 diabetes control strategies.
A recent study from scientists at the Salk Institute for Biological Studies suggests that a strawberry a day (or more accurately, 37 of them) could keep not just one doctor away, but an entire fleet of them, including the neurologist, the endocrinologist, and maybe even the oncologist.
The 25.8 million Americans who have diabetes may soon be free of finger pricks and daily insulin dosing.
A new anti-inflammatory drug used by patients with type 2 diabetes improved their kidney function during a year-long study involving researchers from UT Southwestern Medical Center.
The University of Virginia Health System has received a $300,000 grant to study the “Call to Health” model, which uses text messages, stress reduction and other techniques to help African-American women manage type 2 diabetes.
A new study led by Ryerson University researchers has found that fewer family physicians are referring all of their diabetic patients to diabetes education programs.
A study led by researchers at the Joslin Diabetes Center suggests that adding the amino acid leucine to their diets may help those with pre-diabetes or metabolic syndrome.
An analysis of data from previously published studies indicates that intensive-dose statin therapy is associated with an increased risk of new-onset diabetes compared with moderate-dose therapy, according to a study in the June 22/29 issue of JAMA.
Over the past 2 decades the prevalence of diabetic kidney disease in the U.S. increased in direct proportion to the prevalence of diabetes itself, according to a study in the June 22/29 issue of JAMA.
In a study that included nearly 14,000 patients with rheumatoid arthritis or psoriasis, the use of certain disease-modifying antirheumatic drugs was found to lower the risk of diabetes, according to a study in the June 22/29 issue of JAMA.
Blood vessels and supporting cells appear to be pivotal partners in repairing nerves ravaged by diabetic neuropathy, and nurturing their partnership with nerve cells might make the difference between success and failure in experimental efforts to regrow damaged nerves, Johns Hopkins researchers report in a new study.
The Endocrine Society, American Association of Clinical Endocrinologists and American Diabetes Association urge diabetes patients to remain on their prescribed medications unless instructed otherwise by their healthcare provider
Cedars-Sinai stem cell researchers investigating ways to prevent eye problems in diabetic patients have been awarded a $3 million grant from the National Eye Institute to develop gene therapy in corneal stem cells to alleviate damage to corneas that can cause vision loss.
In an analysis of data from several studies, watching television for 2-3 hours per day or more was associated with a higher risk of type 2 diabetes, fatal and nonfatal cardiovascular disease and all-cause death, according to a study in the June 15 issue of JAMA.
In a mouse study, scientists at Mayo Clinic Florida have demonstrated the feasibility of a promising new strategy for treating human type 2 diabetes, which affects more than 200 million people worldwide.
Heart function may be affected in people with Type 2 diabetes as early as adolescence, according to a new study that will be presented Sunday at The Endocrine Society’s 93rd Annual Meeting in Boston.
Engineering researchers at Rensselaer Polytechnic Institute are combining automation techniques from oil refining and other diverse areas to help create a closed-loop artificial pancreas. The device will automatically monitor blood sugar levels and administer insulin to patients with Type 1 diabetes, and aims to remove much of the guesswork for those living with the chronic disease.
New research finds that gestational diabetes, or pregnancy-related diabetes, may not raise the risk of heart disease independent of other cardiovascular risk factors except in certain high-risk populations, such as Hispanics. The results will be presented Monday at The Endocrine Society’s 93rd Annual Meeting in Boston.
Men with prostate cancer are at higher risk of developing diabetes or diabetes risk factors if they receive androgen deprivation therapy (ADT) to block the production or action of male hormones that can fuel the growth of this cancer. The results of this new study on the second-most common cancer in men are being presented Saturday at The Endocrine Society’s 93rd Annual Meeting in Boston.
An experimental cure for Type 1 diabetes has a nearly 80 percent success rate in curing diabetic mice. The results, to be presented Saturday at The Endocrine Society’s 93rd Annual Meeting in Boston, offer possible hope of curing a disease that affects 3 million Americans.
Researchers from the Centers for Disease Control and Prevention in Atlanta completed a 20-year study that involved closely watching the diets of a group of individuals between the ages of 25 and 74. The study named the first National Health and Nutrition Examination Survey concluded that fruits and vegetables had a demonstratively positive, protective effect against diabetes.
Use of established fracture prediction methods in older patients with type 2 diabetes mellitus (DM) found that scores from these methods were associated with hip and nonspine fracture risk, and a certain score associated with higher risk of fracture compared to persons without DM, according to a study in the June 1 issue of JAMA. Because patients with type 2 DM often have higher levels of bone mineral density (BMD), it has been uncertain the applicability of fracture risk screening methods typically used for patients with lower levels of BMD.
The gold standard long-term glucose monitoring test for patients with diabetes proved to be of limited value in dialysis patients, according to a new study at Wake Forest Baptist Medical Center.
Fifty years ago, adult-onset diabetes was relatively rare, affecting less than one percent of the adult population in the United States. Today, more than 25 million Americans over the age of 20 battle the disease – an alarming 11 percent of the population. The condition has been renamed type 2 diabetes because nearly a quarter of a million children also have it. The Bronx has been especially hard hit, with approximately 150,000 adults and children affected.
New findings out of Wake Forest Baptist Medical Center reveal that a common test may be useful in predicting early death in individuals with diabetes.
Small differences in diet – even without weight loss – can significantly affect risk for diabetes, according to research from UAB in the American Journal of Clinical Nutrition. In this study, 69 healthy, overweight people who did not have diabetes — but were at risk for it — were placed on diets with modest reductions in either fat or carbohydrate for eight weeks. At eight weeks, the group on the lower fat diet had significantly higher insulin secretion and better glucose tolerance and tended to have higher insulin sensitivity, indicating a decreased risk for diabetes.”
A new study by the VA and University of Michigan suggests that mobile phones could help low-income patients across the globe manage diabetes and other chronic diseases.
Joslin Diabetes Center scientists identify promising candidate for drugs treating type 2 diabetes and fatty liver disease.
A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease.
A collaborative effort by investigators at the Salk Institute for Biological Studies recently revealed just how similarly mammals and insects make critical metabolic adjustments when food availability changes, either due to environmental catastrophe or everyday changes in sleep/wake cycles. Those findings may suggest novel ways to treat metabolic conditions such as obesity and type II diabetes.
A new study by researchers at Wake Forest Baptist Medical Center sheds light on what causes certain kidneys to do better than others after being transplanted, providing doctors with an easy way to screen for donor kidneys that have the best chance of survival.
Actor Jerry Mathers is the host of the American Academy of Neurology Foundation’s latest patient education video and guidebook, Diabetic Nerve Pain: A Guide for Patients and Families. The video and guidebook are aimed at answering important questions for people who suffer from nerve pain due to diabetes and can be viewed and downloaded for free by visiting www.aan.com/patients. Printed copies of the guidebook and video may be purchased at www.aan.com/store.
Implementing structured exercise training, including aerobic, resistance or both, was associated with a greater reduction in hemoglobin A1c levels (a marker of glucose control) for patients with diabetes compared to patients in the control group, and longer weekly exercise duration was also associated with a greater decrease in these levels, according to results of an analysis of previous studies, published in the May 4 issue of JAMA.
In the largest study of it kind to establish a link between sleep and diabetes, researchers found that people with diabetes who sleep poorly have higher insulin resistance, and a harder time controlling the disease.
Researchers may have discovered the underlying mechanism that could convert other cell types into insulin-producing pancreatic beta cells.
The angiotensin-converting enzyme (ACE) inhibitor drug, ramipril, is particularly effective in lowering the risk of end-stage renal disease (ESRD) in obese patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
Medical therapies may be developed to recover healthy proteins that are important to prevent diseases such as Alzheimer’s disease and diabetes.
People living in Appalachia are three times more likely to die from diabetes than someone living in most other parts of the United States. Now seven academic centers and community organizations have created the Appalachian Translational Research Network to tackle diabetes, obesity and other health problems using translational science - an approach that uses collaborations to help accelerate the time it takes basic research to become usable health solutions.
A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that while black and white children with vitamin D deficiency both had higher fat levels, black children were more likely to have higher levels of fat just under their skin and white children were more likely to have higher levels of fat between their internal organs.
Researchers at the University of California, San Diego School of Medicine, the National Institutes of Health (NIH) and the Mayo Clinic have published promising results of a clinical study using an experimental anti-fibrotic and anti-inflammatory drug called pirfenidone to treat patients with diabetic nephropathy.
Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes.
The brain’s hypothalamus plays a key role in obesity and one of its major complications – type 2 diabetes. Nerve cells in the hypothalamus detect nutrients and hormones circulating in the blood and then coordinate a complex series of behavioral and physiological responses to maintain a balance between calories eaten and calories burned. Obesity and diabetes can result when this regulatory mechanism goes awry.
Researchers were able to to improve diabetes patients’ health by first addressing their depression.
A new study of older diabetes patients has found that well-controlled blood sugar levels were associated with a lower risk of major complications but the very lowest blood sugar levels were associated with a small but significant increased risk of death.
John Walker, M.D., C.P.E., Chief Medical Officer, Cornerstone Health Care, is presenting Cornerstone’s successful use of Humedica MinedShareTM Ambulatory as a basis for its new Patient Care Advocate program. Joining Dr. Walker in the presentation are John Cuddeback, M.D., Ph.D. Chief Medical Informatics Officer, Anceta and A.G. Breitenstein, J.D., M.P.H., Vice President & General Manager, Provider Markets, Humedica.
Eye examinations every other year are more cost-effective than currently recommended annual eye exams for people with diabetes who are at low risk of diabetic retinopathy progression.
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