Curated News: Cell (journal)

• share
• favorite_border

Mitochondria are remarkable shape-shifting organelles that have long been understood as the powerhouses inside our cells.

• share
• favorite_border

Scientists from the Nara Institute of Science and Technology (NAIST), Advanced Telecommunications Research Institute international, and Tamagawa University have demonstrated that obsessive-compulsive disorder (OCD) can be understood as a result of imbalanced learning between reinforcement and punishment.

• share
• favorite_border

Mutations within Speckled Protein 140 (SP140) are associated with an increased risk of Crohn’s disease

• share
• favorite_border

Researchers at Massachusetts General Hospital (MGH), published a new paper in Cell Reports Medicine demonstrating the protective potential of multiple doses of the Bacillus Calmette-Guerin (BCG) vaccine against COVID-19 and other infectious diseases.

• share
• favorite_border

Researchers in the Biomedical Engineering Department at UConn have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking potential for more thorough preclinical drug development and testing, and model for cardiac diseases.

• share
• favorite_border

Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection, or a combination of the two. But, just how much protection does any individual person have?

• share
• favorite_border

One of the hallmarks of Alzheimer’s disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called microglia contribute to this slowdown of neuron activity.

• share
• favorite_border

A team of Rutgers researchers and others inject parasitic worms into mice to study how injured cells trigger an immune response.

• share
• favorite_border

Researchers have identified a gene that promotes muscle strength when switched on by physical activity, unlocking the potential for the development of therapeutic treatments to mimic some of the benefits of working out.

• share
• favorite_border

Scientists from the RIKEN Center for Integrative Medical Sciences in Japan in collaboration with other researchers from around the world have discovered that recombinations of specific genomic sequences that are repeated millions of times in the genome of each of our cells are pervasively found in both normal and in disease states. Identifying the mechanisms that lead to this myriad of recombinations involving DNA sequences that were once considered as “junk”, may be crucial to understanding how our cells develop and what can make them unhealthy.

• share
• favorite_border

Patients who have indwelling urinary catheters often suffer from urinary tract infections, which can be difficult to treat.

• share
• favorite_border

A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19.

• share
• favorite_border

Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody levels decrease substantially within 3 months, according to new clinical trial data.

• share
• favorite_border

Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue.

• share
• favorite_border

Passive day cooling is a promising technology for the sustainable reduction of energy consumption. It avoids the heating up of buildings by solar radiation and dissipates accumulated heat without external energy consumption.

• share
• favorite_border

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

• share
• favorite_border

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

• share
• favorite_border

Bungarus multicinctus, or the many-banded krait as it commonly called, is a highly venomous elapid snake widely distributed across southern Asia.

• share
• favorite_border

With human iPSC-based brain organoids and mouse chimeras, Jin and colleagues demonstrate that upregulated type-I-interferon (IFN-I) signaling in Down syndrome microglia causes elevated synaptic pruning during development and accelerated senescence, r

• share
• favorite_border

In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling

• share
• favorite_border

Li et al. demonstrate that amino acid catabolism and the GCN2-eIF2α axis control protein synthesis and energy production in hematopoietic stem cells for maintenance and proliferation. They also show that nicotinamide riboside increases amino acid c

• share
• favorite_border

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

• share
• favorite_border

The atypical chemokine receptor 1 (ACKR1) was discovered on erythrocytes as the Duffy blood group antigen (Cutbush et al., 1950), also called Duffy-antigen/receptor for chemokines, or DARC (Novitzky-Basso and Rot, 2012). Erythrocytes are terminally

• share
• favorite_border

In this issue of Cell Stem Cell, Tran and colleagues develop a platform for differentiating thousands of miniature kidney organoids consisting of one or two nephron-like structures each. They use this platform to identify a potent new inhibitor of cy

• share
• favorite_border

Cell competition is a fitness quality control that eliminates cells that are less fit than their neighbors. Nichols, Lima, and Rodríguez review the importance of cell competition in the early mammalian embryo for the elimination of abnormal cells, f

• share
• favorite_border

Duffy antigen receptor for chemokines (DARC)/CD234, also known as atypical chemokine receptor 1 (ACKR1), is a seven-transmembrane domain protein expressed on erythrocytes, vascular endothelium, and a subset of epithelial cells (Peiper et al., 1995).

• share
• favorite_border

Niec et al. integrate spatial and single-cell transcriptomics data and develop computational approaches to finely map the cellular and transcriptional landscape of the intestinal crypt-villus axis. Combining these results with functional experiments

• share
• favorite_border

In this issue of Cell Stem Cell, Xu et al. and Yu et al. use low-input epigenetic profiling techniques to map H3K9me3 deposition in early human development. They reveal stage-specific H3K9me3 deposition on retrotransposons, which may play crucial c

• share
• favorite_border

Wang and colleagues comprehensively compare the landscapes of H3K9me3 between human and mouse early embryos and reveal the roles of hominoid-specific retrotransposons in H3K9me3-dependent heterochromatin remodeling during early human development. The

• share
• favorite_border

Xu et al. profiled the genome-wide H3K9me3 distribution in human oocytes and early embryos. They found the function and mechanism of H3K9me3 modification on long terminal repeat (LTR) regulation and provide a detailed map of the sequential reprogram