Charles Zuker, Ph.D., an investigator of the Howard Hughes Medical Institute whose research focuses on taste as a way to study how the brain processes sensory experiences, will join the Columbia University Medical Center faculty on July 1 as professor of biochemistry & molecular biophysics and of neuroscience in the College of Physicians and Surgeons.
Eating a Mediterranean diet appears to be associated with less risk of mild cognitive impairment"”a stage between normal aging and dementia"”or of transitioning from mild cognitive impairment into Alzheimer's disease, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives journals.
Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder.
A research team led by Richard J. Deckelbaum, M.D., Director of the Columbia Institute of Human Nutrition, has found that a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes.
More and more people are living longer, but living to extreme old age is unusual and tends to run in some families. A new study at Columbia University Medical Center, sponsored by the National Institutes on Aging, aims to learn more about the secrets to a long healthy life. Investigators are seeking long-lived families to help investigate this important question.
An international team of researchers, led by investigators at Columbia University Medical Center, has uncovered the first gene linked to the most common type of epilepsy, called Rolandic epilepsy. One out of every five children with epilepsy is diagnosed with this form, which is associated with seizures starting in one part of the brain.
Airway epithelial cells initiate an immune response to inhaled bacteria by signaling for white blood cells to move from the bloodstream into the lungs and airway to fight potential infection. Researchers at Columbia University Medical Center have demonstrated that this signaling cascade includes the activation of epithelial proteases, a type of enzyme capable of opening the junctions between the cells in the airway mucosa, to enable the white blood cells to get through to the site of the infection.
Steven A. Siegelbaum, Ph.D., a neuroscientist whose research is at the forefront of understanding the role of neural circuitry in learning, behavior and memory, has been named chair of the Department of Neuroscience of Columbia University's College of Physicians & Surgeons (P&S).
Maintaining blood sugar levels, even in the absence of disease, may be an important strategy for preserving cognitive health, suggests a study published by researchers at Columbia University Medical Center (CUMC). The study appeared in the December issue of Annals of Neurology.
Using stem cell lines not typically combined, researchers at Columbia University Medical Center have designed a new way to "grow" bone and other tissues. The work by Jeremy Mao, DDS, Ph.D., published today in the Public Libraries of Science, takes a new approach: rarely have mesenchymal and hematopoietic cells been delivered in combination for the healing of defects and the treatment of diseases "“ partially due to the separate research communities in which these two cell groups are studied.
Researchers at Columbia University Medical Center and the State University of New York at Stony Brook (SUNY) have developed a groundbreaking technique to sneak therapeutic genes past the body's defenses, possibly clearing one of the largest hurdles to realizing the potentials of medically altering a patient's DNA.
Bone growth is controlled in the gut through serotonin, the same naturally present chemical used by the brain to influence mood, appetite and sleep, according to a new discovery. Until now, the skeleton was thought to control bone growth, and serotonin was primarily known as a neurotransmitter acting in the brain. This new insight could transform how osteoporosis is treated by giving doctors a way to increase bone mass, not just slow its loss.
Tobacco use is more prevalent and smoking cessation less likely among persons with Attention Deficit Hyperactivity Disorder (A.D.H.D.) In a study of smokers with attention deficit and hyperactivity symptoms, those who exhibited elevated hyperactivity and impulsivity, with or without inattention, showed lower quit rates after 8 weeks than those with inattention symptoms alone or those without the A.D.H.D. symptoms.
Richard Mayeux, M.D., to receive the NY Academy of Medicine's John Stearns Award for Lifetime Achievement in Medicine, intended to honor extraordinary achievement in multiple areas over a professional lifetime, at the annual meeting of the Fellows of the Academy to be held on November 18 in New York.
Columbia University Medical Center presents the 2008 Naomi Berrie Awards to a nationally recognized diabetes and obesity researcher, and a promising young investigator, for their outstanding achievements in diabetes research.
A study in Nature Medicine describes the function and interaction of a critical molecule involved in cell death in Alzheimer's disease patients. These new findings reveal that blocking this molecule, called Cyclophilin D (CypD), and development of surrounding mitochondrial targets may be viable therapeutic strategies for the prevention and treatment of Alzheimer's disease, according to Shi Du Yan, Ph.D., at Columbia University Medical Center.
A multi-center research team, led by Columbia University Medical Center, has uncovered a major contributor to the cause of stomach cancer "“ the second leading cause of cancer-related mortality in the world. The team described for the first time, that elevated levels of a single proinflammatory cytokine, IL-1β, can start the progression towards stomach cancer.
Donald W. Landry, M.D., Ph.D., a national leader in forging organic chemical solutions to intractable medical problems has been named chairman of the Department of Medicine at the Columbia University College of Physicians and Surgeons and chief of medicine at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Columbia will award the 2008 Horwitz Prize to noted biologists Ulrich Hartl and Arthur Horwich for their work in expanding fundamental understanding of protein folding, and its role in Alzheimer's and other life-threatening diseases. Rosalind Franklin will be honored posthumously for her contributions to the structure of DNA.
A simple blood test to detect whether a person might develop Alzheimer's disease is within sight and could eventually help scientists in their quest toward reversing the disease's onset in those likely to develop the debilitating neurological condition. Building on a study that started 20 years ago with an elderly population in Northern Manhattan at risk or in various stages of developing Alzheimer's disease a Columbia University Medical Center research group has yielded ground-breaking findings that could change the way the disease is treated or someday prevent it.
Endocrinologists and researchers at the Naomi Berrie Diabetes Center at Columbia University Medical Center have discovered that turmeric-treated mice were less susceptible to developing Type 2 diabetes, based on their blood glucose levels, and glucose and insulin tolerance tests.
A simple urine test for the protein NGAL (neutrophil gelatinase-associated lipocalin) can help emergency department physicians more accurately and rapidly diagnose kidney failure, which can result in intensive care admission, dialysis, or even death. This fast and precise test will allow physicians to make evidence-based and potentially lifesaving treatment decisions.
Scans of the genome of patients with schizophrenia have revealed rare spontaneous copy number mutations that account for at least 10 percent of the non-familial cases of the disease. Researchers at Columbia University Medical Center describe specific genetic mutations present in individuals who have schizophrenia, but not present in their biological parents who do not have the disease. These individuals were eight times more likely to have these mutations than unaffected individuals. This new data, reported in the May 30 on-line issue of Nature Genetics, will help researchers account for the persistence of schizophrenia in the population despite low birth rates among people with the disease.
Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders. In the May 11 issue of Nature Genetics, Maria Karayiorgou, M.D., professor of psychiatry, and Joseph A. Gogos, M.D., Ph.D., associate professor of physiology and neuroscience at Columbia University Medical Center explain how they uncovered a previously unknown alteration in the production of microRNAs of a mouse modeled to have the same chromosome 22q11.2 deletions previously identified in humans with schizophrenia.
Columbia University faculty members, Gary Struhl, Ph.D., Carol Prives, Ph.D. and Paul E. Olsen, Ph.D., have been elected members of the prestigious National Academy of Sciences (NAS) for their excellence in original scientific research. Membership in the NAS is one of the highest honors given to a scientist or engineer in the United States.
The following experts from the Department of Obstetrics & Gynecology, Columbia University Medical Center (CUMC) will present new research findings and up-to-date information from the field at the American College of Obstetrics & Gynecology 2008 annual meeting (May 3-8, New Orleans).
Columbia University's College of Physicians & Surgeons and Mailman School of Public Health graduate program faculty in 14 research specialties are ranked among the top 10 nationally for scholarly productivity, as compared to other academic medical centers nationwide. Biochemistry, nutrition, pharmacology and physiology received the highest marks.
The National Alliance for Research on Schizophrenia and Depression (NARSAD), a charity dedicated to mental health research, has announced that it has selected two Columbia University Medical Center and New York State Psychiatric Institute researchers for its prestigious Distinguished Investigator Award: J. John Mann, M.D. and Ezra Susser, M.D., Dr.P.H.
As the second leading cause of death in college students after car accidents, suicide is a serious problem that can affect teenagers and young adults at an age when serious mental illness first manifests itself and often goes undiagnosed. A psychiatrist and an authority on suicide at Columbia University Medical Center and NewYork-Presbyterian Hospital offers parents and students advice on how to spot and address potentially suicidal behavior.
For years, neuroscientists have known that the risk of Alzheimer's disease is nearly doubled among people who have had a stroke. Now researchers at Columbia University Medical Center have found a process in the brain that may help explain the link between Alzheimer's and stroke. Findings are published in the March 13, 2008 issue of Neuron.
A Columbia University Medical Center research team has discovered a new gene involved in determining hair texture in humans. The team's genetic analysis demonstrated that mutations in a gene, known as P2RY5, cause hereditary "woolly hair" "” hair that is coarse, dry, tightly curled and sparse.
What do marathoners and heart failure patients have in common? More than you think according to new findings by physiologists at Columbia University Medical Center. The new study shows that the fatigue that marathoners and other extreme athletes feel at the end of a race is caused by a tiny leak inside their muscles that probably also saps the energy from patients with heart failure.
Novel way of using porous structures as a drug-delivery vehicle helps boost the integration of host tissue with implants, study finds.
An international team of researchers led by Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center and Sweden's Lund University has, for the first time, revealed how mutations in the BRCA1 gene lead to breast cancer. Findings show that one way BRCA1 mutations cause cancer is by knocking out a powerful tumor suppressor gene known as PTEN.
In The New England Journal of Medicine, David J. Brenner, Ph.D., and Eric J. Hall, Ph.D., from the Center for Radiological Research, argue that the potential carcinogenic effects from using CT scans may be underestimated or overlooked. This is of particular concern, because perhaps one-third of all CT scans performed in the United States may not be medically necessary, the radiation researchers say.
Columbia University will award the 2007 Louisa Gross Horwitz Prize to Joseph G. Gall, Ph.D., a cell biologist at the Carnegie Institution's Department of Embryology, Elizabeth H. Blackburn, Ph.D., a biologist and physiologist at the University of California, San Francisco and Carol W. Greider, Ph.D., a molecular biologist and geneticist at the Johns Hopkins University School of Medicine.
Repeated courses of a drug that is used to improve the survival of unborn premature babies also may increase the risk of cerebral palsy in those children, according to results from a multi-center study, funded by the National Institutes of Health and led by Ronald Wapner, M.D., professor of obstetrics and gynecology, Columbia University Medical Center and attending obstetrician and gynecologist at NewYork-Presbyterian Hospital/Columbia.
Columbia University Medical Center researchers, led by Yaakov Stern, Ph.D., have identified a brain network within the frontal lobe that is associated with cognitive reserve, the process that allows individuals to maintain function despite brain function decline due to aging or Alzheimer's disease.
Columbia University Medical Center graduate program faculty in 10 research specialties are ranked among the top 10 nationally for scholarly productivity, with anatomy and nutrition receiving the highest marks.
The International Center for Health Outcomes and Innovation Research, a joint initiative of Columbia University Mailman School of Public Health and the Department of Surgery at Columbia's College of Physicians and Surgeons, has received a $23 million grant from the National Heart, Lung, and Blood Institute to serve as the Data Coordinating Center for a newly established Cardiothoracic Surgery Investigations Network.
Going back to school can be just as stressful for parents as for children. Columbia University Medical Center experts are available to talk about a multitude of aspects of the back to school process, including how to cope with your child's anxiety about going back to school and how to talk to your child's school about their special dietary needs because of diabetes.
Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient's own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
A new initiative from Columbia University Medical Center will be the first to target chronic oral health problems in sub-Saharan Africa, where the vast majority of chronic diseases are left undetected and untreated.
Recent dating violence among urban teen females and lifetime history of sexual assault among urban teen males may be associated with suicide attempts, according to a report in the June issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
Hospitals that have better working conditions for nurses are safer for elderly intensive care unit (ICU) patients, according to a recent report, led by Columbia University School of Nursing researchers that measured rates of hospital-associated infections.
The following research from Columbia University Medical Center and NewYork-Presbyterian Hospital is being presented at the annual meeting of the American Academy of Neurology (AAN), April 28"“May 5, in Boston.
Two papers by Columbia and Harvard researchers report for the first time that astrocytes (the most abundant non-neuronal cells in the central nervous system), which carry a mutated gene known to cause some cases of amyotrophic lateral sclerosis (ALS/Lou Gehrig's disease), induce motor neuron death. This indicates that astrocytes may contribute to ALS by releasing a toxic factor that damages neurons.
Columbia University Medical Center faculty are giving the following presentations at this weekend's American Association for Cancer Research (AACR) annual meeting in Los Angeles (April 14-18, 2007).
The American Academy of Neurology (AAN) is awarding the 2007 Potamkin Prize to Richard Mayeux, MD, MSc, Fellow of the AAN and co-director of the Taub Institute for Research on Alzheimer's and the Aging Brain, Columbia University Medical Center in New York, for his research related to Alzheimer's disease.
New research may explain why people who are able to easily and accurately recall historical dates or long-ago events, may have a harder time with word recall or remembering the day's current events. They may have too much memory, making it harder to filter out information and increasing the time it takes for new short-term memories to be processed and stored.
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