The leading cause of acute gastroenteritis linked to eating raw seafood disarms a key host defense system in a novel way: It paralyzes a cell’s skeleton, or cytoskeleton.
UT Southwestern Medical Center scientists have identified a key protein that helps trigger ketamine’s rapid antidepressant effects in the brain, a crucial step to developing alternative treatments to the controversial drug being dispensed in a growing number of clinics across the country.
UT Southwestern scientists who created a powerful analytic weapon in the fight against cancer and infectious diseases are making that tool available for free via a web-based portal.
Researchers in the Department of Pediatrics at UT Southwestern Medical Center have identified the most effective treatment approach for children diagnosed with iron-deficiency anemia (IDA).
Dennis Kothmann jots several numbers on a clipboard then pauses, his pen frozen on the last figure. His eyebrows furrow and he quietly mouths a calculation.
A new strategy for treating brain tumors may extend or save the lives of patients diagnosed with one of the deadliest forms of cancer, according to a study from UT Southwestern Medical Center.
UT Southwestern Medical Center dedicated its new Monty and Tex Moncrief Medical Center at Fort Worth today, adding more than a dozen specialty areas of its distinctive academic medical practice to the heart of Fort Worth’s burgeoning Medical District.
Scientists have identified more than 100 genes linked to memory, opening new avenues of research to better understand memory processing in the human brain.
The number of motor vehicle fatalities involving children under age 15 varies widely by state, but occurrences are more common in the South, and are most often associated with improperly or unused restraints and crashes on rural roads, a new review of child-related auto fatalities shows.
Patients with non-small cell lung cancer (NSCLC) often respond to standard chemotherapy, only to develop drug resistance later, and with fatal consequences. But what if doctors could identify those at greatest risk of relapse and provide a therapy to overcome or avoid it?
A new DNA vaccine when delivered to the skin prompts an immune response that produces antibodies to protect against toxic proteins associated with Alzheimer’s disease – without triggering severe brain swelling that earlier antibody treatments caused in some patients.
Otherwise healthy young people with high systolic blood pressure over 140 are at greater risk for future artery stiffening linked to an increased risk of stroke as well as possible damage to the kidneys and brain, new research shows.
One in three patients hospitalized for medical problems experienced a drop in their red blood cell count due to the hospitalization – a concept called hospital-acquired anemia, new research showed.
Ryan Dant was afraid. He knew he likely wouldn’t live to see his 11th birthday due to a virulent disease that would stiffen his limbs, attack his heart, and destroy his brain.
UT Southwestern research investigating the blood glucose-regulatory actions of the hormone ghrelin may have implications for development of new treatments for diabetes.
UT Southwestern Medical Center researchers found in a recent phase one clinical trial that stereotactic partial breast radiation was as safe as traditional radiation but decreased treatment time from six weeks to just days.
UT Southwestern Medical Center researchers have identified the cells that directly give rise to hair as well as the mechanism that causes hair to turn gray – findings that could one day help identify possible treatments for balding and hair graying.
Kidney cancer patients may soon have more treatment choices that provide a higher quality of life, thanks to research completed by physician scientists at UT Southwestern Medical Center.
If not for a heart transplant, Drew Wilson would have been dead last fall.
A program that penalizes hospitals for high early readmission rates of heart attack patients may be unfairly penalizing hospitals that serve a large proportion of African-Americans and those with more severe illness, a study by UT Southwestern Medical Center researchers suggests.
An international study based at UT Southwestern Medical Center revealed a striking genetic-environmental interaction: Obesity significantly amplifies the effects of three gene variants that increase risk of nonalcoholic fatty liver disease (NAFLD) by different metabolic pathways.
UT Southwestern Medical Center researchers collaborated with an international team of scientists to achieve a significant milestone in the effort to understand pathogens responsible for some of the world’s most deadly infectious diseases.
Anna Gunby can’t run around as smoothly as most 4-year-olds because her wobbly legs are affected by a rare brain disease that also hinders her intellect. She can’t identify colors. She can’t count objects. Her attention span is short.
Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types.
Researchers from the Peter O’Donnell Jr. Brain Institute will participate in a national study to determine whether medical devices used in the home can diagnose sleep apnea that often develops after traumatic brain injuries (TBI).
Gene-editing alternative corrects Duchenne muscular dystrophy
UT Southwestern Medical Center pediatric researchers have harnessed an analytical tool used to predict the weather to evaluate the effectiveness of therapies to reduce brain injury in newborns who suffer oxygen deprivation during birth.
UT Southwestern Medical Center researchers discovered a small protein named Myomixer essential for the formation of skeletal muscle – findings that could eventually help treat genetic diseases such as muscular dystrophy and other myopathies.
From bustling cities to tiny farming communities, the bright lights of the local stadium are common beacons to the Friday night ritual of high school football.
Five simple medical tests together provide a broader and more accurate assessment of heart-disease risk than currently used methods, cardiologists at UT Southwestern Medical Center found.
Doctors for the first time can determine which medication is more likely to help a patient overcome depression, according to research that pushes the medical field beyond what has essentially been a guessing game of prescribing antidepressants.
Twenty years ago, the federal government funded the study of a condition quietly killing hundreds of Americans a year – acute liver failure, or ALF. Growing evidence had linked ALF to overdoses of acetaminophen, the popular over-the-counter pain medication many viewed as harmless at the time.
A multicenter study on acute liver failure funded by the National Institutes of Health (NIH) has increased understanding of this sometimes fatal condition since the research effort began 20 years ago, improving patient care and saving lives.
Patsy Whittenberg made the six-hour drive from the Texas Panhandle to UT Southwestern Medical Center in Dallas to take advantage of a first for Texas –the latest in Gamma Knife surgery that better protects surrounding brain tissue and offers greater comfort without the need for head restraints.
The parasite that causes deadly sleeping sickness has its own biological clock that makes it more vulnerable to medications during the afternoon, according to international research that may help improve treatments for one of Africa’s most lethal diseases.
How do mammals keep two biologically crucial metabolites in balance during times when they are feeding, sleeping, and fasting? The answer may require rewriting some textbooks.
After evaluating more than 900 differences in the shape and structure of cancer cells, UT Southwestern Medical Center researchers developed a computer model able to predict the most deadly lung cancers based on a fraction of those features.
A drug commonly prescribed to pregnant women with a history of delivering babies early provides no benefit. In fact, this drug may even increase the risk of developing gestational diabetes.
It’s a rare, but tragic, event that occurs less than 20 times a year: Teen athletes who are struck in the chest by a ball, causing their heart to stop. And it can be instantly fatal.
A young songbird sings an intricate melody from its caged perch, trying to echo the mating song heard so many times from his father.
Could lung cancer be hiding in kidney cancer patients? Researchers with the Harold C. Simmons Comprehensive Cancer Center’s Kidney Cancer Program studied patients with metastatic kidney cancer to the lungs and found that 3.5 percent of the group had a primary lung cancer tumor that had gone undiagnosed. This distinction can affect treatment choices and rates of survival.
As we embark on another spring of sunlit evenings, who better to address how daylight saving time affects our body clock than the father of the CLOCK gene: Dr. Joseph Takahashi of the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center.
UT Southwestern Medical Center microbiologist Dr. Neal Alto has been named a recipient of the 2017 Norman Hackerman Award in Chemical Research for his work on interspecies communication between disease-causing bacteria and the humans they infect.
A large national study suggests that treating pregnant women for mildly low thyroid function does not improve the IQs of their babies or reduce preterm births or other negative outcomes.
Lack of exercise and excessive weight are strongly associated with a type of heart failure that has a particularly poor prognosis, UT Southwestern Medical Center researchers determined in an analysis of data from three large studies.
More than three decades after surviving breast cancer, Susanne Calabrette faced a second scare. In June 2016, an MRI for an unrelated condition revealed she had pancreatic cysts, giving her a chance for a pre-emptive strike against this killer cancer.
How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose tools of neuronal communication to fuel aggressive tumor growth and spread.
A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.
Researchers at UT Southwestern Medical Center, working with a California biotech firm, have developed a potential drug to treat polycystic kidney disease – an incurable genetic disease that often leads to end-stage kidney failure
If wine and chocolate are on the menu for Valentine’s Day, you might be doing your heart a tiny little favor, but moderation remains key, says Dr. Joseph Hill, Chief of Cardiology at UT Southwestern Medical Center.
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