New Treatment in Pipeline for Patients with Hypertrophic Cardiomyopathy
Lahey Hospital & Medical CenterOne of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity. While invasive interventions can restore selected patients’ quality of life, pharmacologic therapies that are safe, well-tolerated and that reliably improve how patients feel and function remain an unmet need for patients with obstructive HCM. Now, a phase 3 trial has shown that a cardiac myosin inhibitor called aficamten enhances exercise capacity in patients with HCM and leads to significant relief in the burden of limiting symptoms, improving the quality of patients' lives