Scientists have identified four new genes associated with the severe food allergy eosinophilic esophagitis (EoE). Because of the genes' apparent functional roles, the findings may point toward potential new treatments for EoE.
Researchers from CHOP presented findings on pediatric heart disease: 3-D prototype printing of heart anatomy, the use of AEDs in infants, long-term cardiac risk in Fontan survivors, and whether cardiac cath volumes correlate with better outcomes.
According to a new study from researchers at The Children's Hospital of Philadelphia's PolicyLab, the proportion of US-born, Medicaid-enrolled children in Pennsylvania who utilized preventive dental care rose significantly for children ages 5-10 years from 2005-2010, with marked gains among Latino children.
A new study from The Children’s Hospital of Philadelphia (CHOP) provides valuable evidence that New Jersey’s Graduated Driver Licensing (GDL) decal provision is associated with a sustained two-year decline in crash rates among intermediate or probationary teen drivers.
The Children's Hospital of Philadelphia and Temple University have received a joint $4.3 million, four-year grant from the NIMH to investigate new methods to eradicate HIV that lurks in brain cells despite conventional antiviral treatments.
New work by a pioneering scientist details how subtle changes in mitochondrial function may cause a broad range of common metabolic and degenerative diseases.
In children with a heart condition, lymph can ooze into airways and dry into a rubbery, potentially life-threatening cast. A new, noninvasive treatment cleared this blockage in a 6-year-old boy.
A program that provides guidance to primary care physicians about appropriately prescribing antibiotics for children is effective, but its improvements wear off after regular auditing and feedback are discontinued.
The Children's Hospital of Philadelphia has joined a new consortium announced today by the National Institutes of Health to advance the treatment of chronic inflammatory diseases called eosinophilic disorders.
The Children’s Hospital of Philadelphia's Autism Roadmap is a comprehensive, one-stop web site to help families navigate accurate, up-to-date information about autism spectrum disorder (ASD). The web site provides families customized information based on what they need- whether their child has just been diagnosed, or they’ve hit an obstacle and are looking for new ideas and resources.
An international research team has identified gene mutations causing severe, difficult-to-treat forms of childhood epilepsy. Many of the mutations disrupt functioning in the synapse, the junction at which nerve cells intercommunicate.
An international team of scientists has identified a gene mutation that causes aplastic anemia, a serious blood disorder in which the bone marrow fails to produce normal amounts of blood cells. The gene regulates telomeres on the ends of chromosomes.
Investigating a protein known to influence human glucose levels, scientists found that this factor has a broader reach than first thought, acting on key gene pathways involved in cardiovascular, neuropsychiatric, and cancer-related diseases.
Antivenom treatment for a snake bite is particularly expensive, both from the costs of antivenom itself and from the close patient monitoring that is medically necessary after its use. A new analysis of data from nearly three dozen U.S. children’s hospitals suggests that the billing classification system sometimes applied to this treatment may not be appropriate.
Scientists have altered key biological events in red blood cells, causing the cells to produce a form of hemoglobin normally absent after the newborn period. This approach may lead to a novel treatment for sickle cell disease.
A large new genetic study in thousands of children and adolescents offers early glimpses of the overall patterns and connections among cognitive abilities such as language reasoning, reading skill and types of memory. The findings may lead to new tools in understanding human cognitive development and neuropsychiatric disorders.
CHOP's Divistion of Pathology & Laboratory Medicine was again awarded the prestigious accreditation of the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP's Accreditation Programs.
Human milk is infant food, but for sick, hospitalized babies, it’s also medicine. That’s the central premise of a series of articles in a neonatal nursing journal’s special issue focused on human milk for sick newborns.
Staff members who joined structured team debriefings after emergency care for children suffering in-hospital cardiac arrests improved their CPR performance and substantially increased rates of patients surviving with favorable neurological outcomes.
As daily temperatures increase, so does the number of patients seeking treatment for kidney stones. In a study that may both reflect and foretell a warming planet’s impact on human health, a research team found a link between hot days and kidney stones in 60,000 patients in several U.S. cities with varying climates.
The first genome-wide analysis of postsurgical pain in children has identified gene variants that affect a child's need for pain-control drugs. The findings may advance the process of calibrating pain-medication doses to a child's genetic makeup.
Trained non-physician evaluators who studied retinal images transmitted to a remote central reading center successfully identified newborn babies likely to require a specialized medical evaluation for retinopathy of prematurity (ROP).
Guidelines released today by Canadian pediatric emergency medicine researchers are in line with the work that has been taking place over the past several years at CHOP to help improve pediatric concussion diagnosis and treatment and standardize youth concussion care.
TheResearchers at The Children’s Hospital of Philadelphia’s PolicyLab found an increase in the concurrent prescribing of second-generation antipsychotics (SGA) – typically used to treat severe mental disorders – with other psychotropic medications among Medicaid-enrolled youth. From 2004-2008, the majority of Medicaid-enrolled youth using SGA were prescribed this medication concurrently with another psychotropic medication class. Researchers say the data is a rich resource for providing a picture of clinical practice trends on a national scale and can valuable in informing policies and practice around SGA use.
The Children’s Hospital of Philadelphia today launched the Fetal Neuroprotection and Neuroplasticity Program. The Program will investigate innovative therapies to protect brain development and to prevent brain injury as early as possible before birth.
Research published in JAMA Pediatrics and the Journal of Adolescent Health found that TeenDrivingPlan, a web-based intervention designed by researchers at The Children's Hospital of Philadelphia to help parents more effectively supervise driving practice, improved the driving performance of pre-licensed teenagers.
A population-based analysis of millions of U.S. births over 15 years finds that many babies, nearly 1 in 25, are born earlier than medically justified, through elective cesarean sections and elective induced labor.
New research describes details of how a diabetes-related gene functions on biological pathway that affects the release of insulin. Finding drugs that act on that pathway may eventually lead to a new treatment for type 1 diabetes.
A new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism. These networks may offer atractive targets for developing new autism drugs or repurposing drugs for other indications.
Hoy, un equipo de expertos del Hospital de Niños en Filadelfia lanzó un nuevo sitio web en idioma español, AfterTheInjury.org/es, para ayudar a los padres de habla hispana a ayudar a sus hijos a recuperarse después de una lesión. En el sitio, los padres pueden ver videos breves, descargar hojas de consejos y crear un plan de atención personalizado según la situación particular de su hijo. El sitio web es un recurso gratuito integral para padres, desarrollado por un equipo de pediatras, psicólogos, cirujanos especializados en traumatismos y enfermeros de traumatismos, basado en más de una década de investigaciones sobre lesiones infantiles y sus efectos emocionales en los niños y sus padres.
Beverly J. Lange, M.D., an exemplary physician and researcher at The Children’s Hospital of Philadelphia (CHOP) for over 40 years, will receive the 2014 Distinguished Career Award from the American Society of Pediatric Hematology/Oncology (ASPHO).
The Advances in Neuroblastoma Research Association (ANRA) is conferring its highest honor, the ANRA Lifetime Achievement Award, on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children’s Hospital of Philadelphia (CHOP).
The Children’s Hospital of Philadelphia announced its Violence Prevention Initiative (VPI) in a press conference on Monday. The VPI programs concentrate CHOP’s medical, mental health, provider training, research expertise and public health policy experience to interrupt violence while ensuring that limited resources are spent efficiently with the greatest chance for impact. Interventions occur at locations that are relevant to CHOP patients - within schools, primary care and hospital sites.
A unique, noninvasive method measures the disassembly of biodegradable nanoparticles that can be used to deliver medicines to patients. The technique is a necessary stop in translating nanoparticles into clinical use.
Mothers give a newborn baby a gift of germs—germs that help to kick-start the infant’s immune system. But antibiotics, used to fight bacterial infection, may paradoxically interrupt a newborn’s own immune responses.
Beverly L. Davidson, Ph.D., a nationally prominent expert in gene therapy, is joining The Children's Hospital of Philadelphia today. She investigates gene therapy for inherited genetic diseases that attack the central nervous system, especially childhood-onset disorders.
Pedigrees are diagrams showing how inherited diseases may occur in a particular family. A new app now lets healthcare providers create pedigrees digitally with few finger taps during a face-to-face patient encounter.
Two recent genetic studies expand the list of genes involved with body fat and body mass index, and their connection to major Western health problems: heart disease, high blood pressure and type 2 diabetes.
Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. The more severe allergy is eosinophilic esophagitis (EoE), which has been increasing in recent years.
A large international study has discovered 11 new genetic signals associated with blood pressure levels. Ten of these signals are "druggable"--in regions with genes encoding proteins that appear to be likely targets for existing drugs or drugs in current development.
Immunogenetics experts at CHOP have developed a unique laboratory test for HLA typing. Relying on next-generation sequencing, the new, more comprehensive test may improve transplantation outcomes and expedite donor matching in bone marrow registries.
New genetic evidence strengthens the case that one well-known type of cholesterol is a likely suspect in causing heart disease, but also casts further doubt on the causal role played by another type. The findings may guide the search for improved treatments.
Gerald B. Shreiber, founder, chairman, president and chief executive officer of South Jersey-based J&J Snack Foods Corp., was in attendance along with his family, J&J Snack Food Employees, CHOP patient-families, pet therapy teams and therapy dogs, at an event at the hospital today to unveil plans to expand the program.
A network of children’s hospitals, data partners, and specialty networks led by The Children’s Hospital of Philadelphia was recently approved for an award from the Patient-Centered Outcomes Research Institute (PCORI) to develop and expand its work as part of PCORnet: the National Patient-Centered National Clinical Research Network.
Katherine A. High, M.D., of The Children’s Hospital of Philadelphia was honored for her trailblazing scientific and clinical research in the bleeding disorder hemophilia with the 2013 E. Donnall Thomas Prize from the American Society of Hematology.
Scientists who fed a cocktail of key amino acids to mice improved sleep disturbances caused by brain injuries. The findings suggest a potential dietary treatment for millions of people affected by traumatic brain injury.
For medical devices, the market for children is a small fraction of the adult market, and there are far fewer child-sized devices. Philadelphia engineers and biomedical researchers are joining forces in a consortium to address this unmet need in child health.
Hematology researchers have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period. These cell culture findings may lead to a new therapy for sickle cell disease.
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