Nearly 90 percent of children and adults with a highly aggressive form of acute lymphoblastic leukemia (ALL) showed no evidence of cancer after receiving a novel, personalized cell therapy that reprograms a patient's immune system.
An international scientific team has discovered a gene associated with a high risk of severe childhood asthma. The specific gene variant may be an actual cause of this form of asthma, a leading cause of hospitalization in young children.
Harvest, an open-source, highly interactive software toolkit introduced by a team of informatics experts and researchers, enables biomedical researchers to explore their data without having to become specialized database technicians.
Children who undergo transplants of solid organs have a high risk of developing advanced kidney disease, according to a new national study. The findings reinforce the importance of continued screening of kidney function in these children.
The Children’s Hospital of Philadelphia (CHOP) announced today that it has removed dietary supplements from its formulary, making it the first hospital in the U.S. to discourage patients from using these products without a doctor’s provision as a matter of policy. The hospital said the action was being taken because the Food and Drug Administration (FDA) does not routinely review the manufacturing of dietary supplements, and therefore cannot guarantee their safety and effectiveness.
David Rubin, MD, MSCE, who co-directs PolicyLab at The Children's Hospital of Philadelphia, was recently appointed to a federal government commission tasked with working to end child abuse and neglect-related deaths. Dr. Rubin is one of 12 experts to be named to the Commission to Eliminate Child Abuse and Neglect Fatalities, and one of just six appointed by President Obama. Notably, Dr. Rubin is the only health care provider appointed to the commission.
Genetics experts from The Children's Hospital of Philadelphia are among the leaders of a major international collaboration researching why patients with chromosome 22q11.2 deletion syndrome have a higher risk of schizophrenia.
Pediatric researchers have found race- and ethnicity-based disparities in pain management and length of stay among children who came to hospital emergency departments for treatment of abdominal pain.
A series of 6 infographics on Youth Concussion Management is now available for free download from the Children's Hospital of Philadelphia's "Minds Matter" Initiative.
Vaccines on the Go: What You Should Know is a unique mobile app that allows busy parents to access up-to-date, reliable information about the science and safety of vaccines -- wherever and whenever they need it. The Vaccine Education Center at The Children's Hospital of Philadelphia (VEC) now offers the App for both iPhone and Android.
By carefully adjusting the function of crucial immune cells called Tregs, scientists may have developed a completely new type of cancer immunotherapy—harnessing the body’s immune system to attack tumors.
A large multicenter study has found that current non-invasive techniques for respiratory support are less effective than widely assumed, in reducing the incidence of severe lung injury in very premature infants.
Proton therapy, using high-energy subatomic particles, may offer a precise, organ-sparing treatment option for children with high-risk forms of neuroblastoma.
Scientists reprogrammed skin cells from patients with rare blood disorders into human induced pluripotent stem cells, highlighting the great promise of iPSCs in advancing understanding of and eventually treating such diseases.
As federal and state policies encouraging people to be covered by health insurance go into effect, this study signals a need to prepare for potential large increases in demand for care of minor and moderate pediatric and young adult injuries in both emergency department and outpatient settings.
“Finding a common cellular response reveals that some order exists in the chaos of these basic energy diseases,” said study leader Marni J. Falk, M.D. “Identifying the central factors regulating manifestations of mitochondrial disease is like troubleshooting a household electrical system: instead of analyzing problems that may occur at each individual light bulb or switch plate, we have located a central problem in the fuse box.”
Educating pediatricians in their offices, and auditing their prescription patterns, encourages them to choose more appropriate antibiotics for children with common respiratory infections.
Obese teenagers who reduced their body mass index (BMI) by 8 percent or more had improvements in insulin sensitivity, an important metabolic factor related to the later development of type 2 diabetes.
Children with obstructive sleep apnea who had a common surgery to remove their adenoids and tonsils had notable improvements in behavior, quality of life and other symptoms compared to those treated with “watchful waiting.”
Researchers from The Children's Hospital of Philadelphia and Penn Medicine find better outcomes for efavirenz over nevirapine in children over age 3.
New report recommends technology, policy changes to better protect older children and adolescents in crashes.
New, low-tech teaching techniques used by novice instructors may improve training for healthcare providers in performing cardiopulmonary resuscitation (CPR) on children who suffer cardiac arrest. Researchers in a large multicenter study say their findings hold the potential to standardize and upgrade life support training by hundreds of thousands of instructors around the world.
A physician-researcher from The Children’s Hospital of Philadelphia, John M. Maris, M.D., will lead the first-ever pediatric “Dream Team” solely focused on creating new treatments for the most challenging childhood cancers.
A report released today by Children's Hospital of Philadelphia and State Farm measured a 47 percent decline in teen driver-related fatalities since 2008. Teen passenger fatalities declined 30 percent in crashes involving teen drivers, most teen passengers ‘always’ buckle up, and less than a quarter ride with drivers who were drinking. Still, as recent high-profile crashes illustrate, crashes remains the leading cause of death for U.S. teens. Risky behaviors- like smartphone use while driving, driving after drinking, and low seat belt use- remain serious problems, and experts see specific opportunities to "apply the gas" to these common factors in crashes involving teen drivers.
The Children’s Hospital of Philadelphia and Pfizer, Inc., are joining forces with the goal of translating biomedical discoveries into novel treatments. CHOP is participating in Pfizer's Centers for Therapeutic Innovation (CTI) network.
Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments.
Two children with an aggressive form of leukemia had a complete remission of their disease—showing no evidence of cancer cells in their bodies—after treatment with a novel cell therapy that reprogrammed their immune cells.
Children who are later diagnosed with autism have subtle but measurable differences in attention as early as 7 months of age, finds a study published today in the American Journal of Psychiatry. Results indicate a precursor to “sticky attention” problems seen in children with autism
Pediatric oncologist Garrett M. Brodeur, M.D., of The Children's Hospital of Philadelphia, will receive one of the highest awards of the American Society of Clinical Oncology (ASCO): its Pediatric Oncology Award and Lecture.
Paul M. Weinberg, M.D., F.A.A.C., a pediatric cardiologist at The Children’s Hospital of Philadelphia, received the 2013 Distinguished Teacher Award from the American College of Cardiology.
The Children’s Hospital of Philadelphia (CHOP) community is deeply saddened to learn of the death of Dr. C. Everett Koop. Dr. Koop served as CHOP’s surgeon-in-chief from 1946 to 1981, before taking on the role of U.S Surgeon General.
The poor growth seen in children born with complex heart defects may result from factors beyond deficient nutrition. A new study by pediatric researchers suggests that abnormalities in overall growth regulation play a role.
By broadly comparing the DNA of children to that of elderly people, gene researchers have identified copy number variations that influence lifespan, either by raising disease risk or by providing protection from disease.
A scientific team has expanded next-generation sequencing to create an off-the-shelf tool that does simultaneous whole-exome analysis of both nuclear and mitochondrial DNA. The test will aid genetic diagnosis of these complex disorders.
A novel software tool streamlines the detection of disease-causing CNVs through more sensitive detection methods and by automatically correcting for variations that reduce the accuracy of results in conventional software.
Experts from The Children’s Hospital of Philadelphia were among the leaders of two large national studies showing that extending CPR longer than previously thought useful saves lives in both children and adults after in-hospital cardiac arrest.
An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Unexpectedly, the scientists found relatively few recurrent gene mutations.
Genetics researchers have identified 25 copy number variations (CNVs) that occur in some patients with autism. While individually rare, these CNVs are “high impact,” strongly increasing a person's autism risk.
The federal Patient-Centered Outcomes Research Institute (PCORI) announces $2M award for CHOP to study long-term antibiotic delivery for children with serious infections
The Children’s Hospital of Philadelphia and BGI-Shenzhen today announced a formal agreement to collaborate on research into next-generation sequencing and analysis of pediatric brain tumors.
State home-visiting program for first-time mothers is using research from The Children's Hospital of Philadelphia's PolicyLab to inform changes to address injury rates. Researchers, program directors say consistent evaluation is key to informing successful programs.
By reprogramming a 7-year-old girl’s own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed after conventional treatment.
Using powerful gene-analysis tools, researchers have discovered mutations in two related genes, ARID1A and ARID1B, that are involved in the most aggressive form of the childhood cancer neuroblastoma.
Researchers have discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, including outcomes such as adult height, risk of type 2 diabetes and adult blood pressure.
While pediatricians and ER physicians value their role in concussion management, a study of their knowledge, practices and attitudes points to the need for training and tools to support optimal patient care. The study, released today in Pediatrics, served as a catalyst for CHOP to create a “medical home” model for managing pediatric concussion.
The Center for Autism Research at The Children’s Hospital of Philadelphia (CHOP) is among The Children’s Miracle Network’s (CMN) “Ultimate Gift” beneficiaries for its social media-based holiday fundraising program, Give Miracles. In addition to its social media presence, ads announcing the campaign for CHOP will run in the Wall Street Journal on November 10th and 24th, and on December 1st and 15th.
Scientists from The Children's Hospital of Philadelphia presented new findings this week in pediatric heart disease. Topics included racial disparities in sudden cardiac death, novel 3D imaging and concurrent organ transplants.
A large international study has identified three new gene variants associated with body mass index (BMI) levels in adults. Genome scientists who led the study say the findings may provide fundamental insights into the biology of adult obesity.
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