The Children’s Hospital of Philadelphia has received funding through the Bill & Melinda Gates Foundation for research on controlling HIV infection, using a novel approach--a drug called a BET antagonist.
Pediatric researchers who tested newborn animals with a human drug used in adults with diabetes report that this drug, when given very early in life, prevents diabetes from developing in adult animals.
A genetically engineered clotting factor that controlled hemophilia in an animal study offers a novel potential treatment for human hemophilia and a broad range of other bleeding problems.
Paul Offit, M.D., is expert in virology and immunology.
New resource for parents and physicians released at Annual American Academy of Pediatrics Meeting.
Knee injuries in children with tears of the anterior cruciate ligament (ACL) and meniscus have increased dramatically over the past 12 years, say orthopaedic surgeons from The Children’s Hospital of Philadelphia.
Experts from The Children’s Hospital of Philadelphia will make presentations on vaccines, fetal surgery, sudden cardiac arrest and sports injuries at this year's annual meeting of the American Academy of Pediatrics.
The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people. The findings shed light on gene networks in the disorder.
Obese teenagers who don’t get the proper amount of sleep may have disruptions in insulin secretion and blood sugar levels, say researchers. Optimal sleep duration may lower these teens' risk of developing type 2 diabetes.
Making use of a new “super resolution” microscope that provides sharp images at extremely small scales, scientists have achieved unprecedented views of the immune system in action.
Researchers seeking rare gene variants in ADHD found that one patient had causative mutations in an unrelated disorder. The finding has implications about how to best return such information to research subjects.
Using an innovative, precise gene therapy tool called genome editing, scientists treated the blood clotting disorder hemophilia in mice. It's the first time in vivo genome editing has achieved clinically meaningful results.
In a step toward personalized genomics, a research team has identified the disease-causing mutation in a newly characterized rare genetic disease, by analyzing DNA from just a few individuals.
The Genome Wowser lets researchers traverse the human genome on an iPad, like planning a travel route on Google Maps. The free app, developed by The Children's Hospital of Philadelphia, is convenient, intuitive and highly mobile.
Health services researchers who studied controversial aspects of Medicare spending and quality of patient care received a prestigious award yesterday from the nation’s largest health services research professional association.
A human drug that both prevents and cures kidney failure in mice sheds light on disabling human mitochondrial disorders, and may represent a potential treatment in people with such illnesses.
By analyzing complex interactions of the immune system in an animal study, researchers have found potential tools for controlling a cytokine storm, a life-threatening condition that may strike children who have juvenile arthritis and other autoimmune diseases.
A new genomics study sets the stage for the first predictive diagnostic test in a serious childhood disorder--common variable immunodeficiency disease (CVID). Early diagnosis may facilitate treatment before CVID progresses.
Katherine A. High, M.D., a gene therapy expert at The Children’s Hospital of Philadelphia, has been elected to the 2011 class of the American Academy of Arts and Sciences.
Building on extensive lab research using magnetically guided nanoparticles to deliver drugs to diseased blood vessels, The Children’s Hospital of Philadelphia has spun off its first startup company, Vascular Magnetics, Inc. (VMI).
In a novel approach that works around the gene defect in Wiskott-Aldrich syndrome, an inherited immune deficiency disorder, researchers used immunotherapy to significantly improve immune function in a 13-year-old boy.
A recent study by The Children’s Hospital of Philadelphia (CHOP) and State Farm Insurance Companies ® hones in on the most common errors teen drivers make that lead to a serious crash. Teen drivers are involved in fatal crashes at four times the rate of adults. The findings were published in the journal Accident Analysis and Prevention. Researchers analyzed a nationally-representative federal database of more than 800 crashes involving teen drivers and identified a few common “critical errors” that are often one of the last in a chain of events leading up to a crash.
Promising new research reveals a potentially highly effective treatment for heterotopic ossification (HO), a painful abnormal buildup of bone tissue. HO has two main forms—one in children, another in wounded soldiers.
Primary care doctors are less likely to refer short girls than short boys for diagnostic testing that can reveal underlying medical reasons for their short stature, according to a new study of an urban pediatric population.
A pilot study in healthy children and adolescents shows that it is feasible to screen for undiagnosed heart conditions that increase the risk of sudden cardiac arrest (SCA).
New research may be relevant to how a mother’s diet during pregnancy influences obesity in her children. Rats fed a high-fat prenatal diet had offspring that were obese, an effect prevented by prenatal antixodidants.
Sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, has another possible use—helping children and young adults with congenital heart disease to better tolerate exercise.
New research confirms that the genetic roots of autism are highly complicated, but that common biological themes underlie this complexity. Autism-related genes play key roles in synaptic function and neurotransmission.
New research enhances the current knowledge of how HIV-1, which causes AIDS, controls the cell cycle of cells that it infects. The new findings may shed light on how the virus reactivates from a latent state.
In a finding that may potentially improve survival from war injuries and disasters, laboratory researchers report that refrigerated whole blood may have a shelf life well beyond the current standard of 24 to 48 hours.
The Children’s Hospital of Philadelphia today announced the establishment of the Jeffrey Modell Endowed Chair in Pediatric Immunology Research, held by pediatric immunologist Jordan S. Orange, M.D., Ph.D.
Performing delicate surgery in the womb, months before birth, can substantially improve outcomes for children with a spina bifida, a common, disabling birth defect of the spine.
After analyzing hundreds of proteins produced by the DNA of tumor cells, researchers have identified one kinase that may be central to a new treatment for the often-fatal childhood cancer neuroblastoma.
A new meta-analysis of data from more than 100,000 people has identified novel variants in over two dozen genes associated with adult height. The study team's technique may be useful in discovering genes in complex diseases.
Pediatric cancer researchers at The Children’s Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children.
Douglas A. Coulter, Ph.D., a neuroscientist at The Children’s Hospital of Philadelphia, received the 2010 Epilepsy Research Recognition Award for Basic Science from the American Epilepsy Society.
A large genetic study of people with major depression has found that a duplicated region of DNA on chromosome 5 predisposes people to the disorder. The gene at that site influences nerve cell development.
Pediatric cancer researchers have identified variations in a gene as important contributors to neuroblastoma, the most common solid cancer of early childhood. The LMO1 gene drives the cancer's progression.
Vivian G. Cheung, M.D., a geneticist at The Children’s Hospital of Philadelphia, received the Curt Stern Award of the American Society of Human Genetics on Sat., Nov. 6, at the Society’s 60th Annual Meeting in Washington, D.C.
Scientists at The Children’s Hospital of Philadelphia have identified both common and rare gene variants associated with the eating disorder anorexia nervosa. It is the largest genetic study of this condition.
A pediatric immunologist at The Children’s Hospital of Philadelphia collaborated with European gene therapy researchers who achieved marked clinical improvements in two children with Wiskott-Aldrich syndrome.
Douglas C. Wallace, Ph.D., a pioneer in human mitochondrial genetics, has joined The Children’s Hospital of Philadelphia to continue his investigations into the role of mitochondrial energy in health and disease.
Pediatric researchers at The Children’s Hospital of Philadelphia describe a successful program in which nurses helped mothers attain high rates of breast-feeding in very sick babies--newborns with complex birth defects requiring surgery and intensive care.
For a fetus diagnosed prenatally with the severe heart defect hypoplastic left heart syndrome, surgery affords an excellent chance of early survival in two thirds of cases. A comprehensive prenatal evaluation is essential.
A new study by pediatric researchers has added to the evidence that genes have a strong influence on childhood obesity. The study team searched the whole genomes of thousands of obese children for copy number variations.
In a collaborative effort in the field of developmental disabilities, The Children’s Hospital of Philadelphia will house the Network Coordinating Center for the new Developmental-Behavioral Pediatrics Research Network.
One of the world’s leading experts in bone marrow failure and related blood disorders recently joined The Children’s Hospital of Philadelphia. Hematology researcher Monica Bessler, M.D., Ph.D., arrived at the hospital this summer.
Using immunotherapy—biologic agents that stimulate the body’s immune system—pediatric oncologists have achieved the first substantial increase in over a decade in cure rates for the childhood cancer neuroblastoma.
A physician or nurse making rounds can locate and page through a 200-page handbook listing possible adverse events that may occur to children in a clinical trial, or can instead store all the information in a 4-ounce iPhone.
Pediatric researchers have discovered a new biological pathway in which small segments of RNA, called microRNA, help protect red blood cells from injury caused by chemicals called free radicals.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right