• share
• favorite_border

• share
• favorite_border

UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.

• share
• favorite_border

The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.

• share
• favorite_border

In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.

• share
• favorite_border

The heart transplant program at UC San Diego Health has demonstrated the best one-year survival rate for patients in the United States among health care providers with a volume of more than 50 heart transplants per year, according to the Scientific Registry of Transplant Recipients.

• share
• favorite_border

• share
• favorite_border

• share
• favorite_border

UC San Diego Health has been recognized among the nation’s best hospitals for 2019-20 by U.S. News & World Report. The annual “Best Hospitals” rankings are designed to assist patients and their doctors in making informed decisions about where to receive care for challenging health conditions.

• share
• favorite_border

A genome-wide association study of more than 165,000 U.S. veterans confirms a genetic vulnerability to post-traumatic stress disorder, specifically noting abnormalities in stress hormone response and/or functioning of specific brain regions.

• share
• favorite_border

• share
• favorite_border

UC San Diego researchers have used the transcriptome — the sum of all messenger RNA (mRNA) molecules expressed from genes — to map protein-gene interactions involved in Alzheimer’s disease.

• share
• favorite_border

University of California San Diego School of Medicine scientists say the loss of a single gene two to three million years ago in our ancestors may have resulted in a heightened risk of cardiovascular disease in all humans as a species, while also setting up a further risk for red meat-eating humans.

• share
• favorite_border

The T. Denny Sanford Institute for Empathy and Compassion at UC San Diego will investigate the neurological basis of compassion, design a compassion-focused medical curriculum and develop new methods to protect and promote the well-being of current clinicians and their patients.

• share
• favorite_border

A dysfunctional enzyme involved in building cancer cell membranes helps fuel tumor growth; when it’s disabled or depleted in mouse models, tumors shrank significantly.

• share
• favorite_border

UC San Diego will launch a payload of stem cell-derived human brain organoids to the International Space Station. Researchers will document how these “mini brains” organize into the beginnings of a functional brain with implications for the future of human life in space.

• share
• favorite_border

Adolescent depression increases with exposure to pesticides, a study in the Ecuadorian Andes shows.

• share
• favorite_border

UC San Diego School of Medicine researchers identified chemical compounds that prevent stress-induced clumping of TDP-43 protein in ALS motor neurons grown in the lab — a starting point for new ALS therapeutics.

• share
• favorite_border

Zebrafish, a pet shop staple, may hold the clue for how hearts can heal from damage.

• share
• favorite_border

UC San Diego Health has expanded north for primary care options with the opening of our Encinitas clinic, which will offer pediatrics, family medicine and Express Care.

• share
• favorite_border

Slow-evolving elephant shark reveals hormonal adaptation and offers new insights into human physiology.

• share
• favorite_border

A new study shows California sexual harassment rates above national average.

• share
• favorite_border

Researchers at University of California San Diego School of Medicine found higher blood pressure and pesticide exposures in children associated with a heightened pesticide spraying period around the Mother’s Day flower harvest. This study involved boys and girls living near flower crops in Ecuador.

• share
• favorite_border

Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, report researchers at University of California San Diego School of Medicine in a published study.

• share
• favorite_border

University of California San Diego School of Medicine research expands and deepens the association between clinical depression and pain, identifying specific regions of the brain that drive, influence and moderate depressive mood and its relationship to perceiving physical pain.

• share
• favorite_border

UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.

• share
• favorite_border

• share
• favorite_border

In its first-ever assessment of biomedical institutions around the world, based upon published research in a targeted set of high-quality scientific journals, the 2019 Nature Index ranked University of California San Diego ninth among the top 200 institutions in biomedical sciences worldwide.

• share
• favorite_border

A recent study by researchers at University of California San Diego School of Medicine, San Diego State University and the Max Planck Institute for Developmental Biology found that the age and sex of an individual strongly influences the bacterial diversity of the gut microbiome.

• share
• favorite_border

Exposure to glyphosate, the primary ingredient in the popular weed killer Roundup, correlates to more severe cases of nonalcoholic fatty liver disease.

• share
• favorite_border

Using stem cells derived from six people, UC San Diego School of Medicine researchers recapitulated retinal cells in the lab. This “eye-in-a-dish” model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.

• share
• favorite_border

In a new study of older adults living in a senior continuing care facility, researchers at University of California San Diego School of Medicine parse how distinctive factors, such as wisdom, loneliness, income and sleep quality, impact the physical and mental functioning of older persons.

• share
• favorite_border

University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease upon diagnosis.

• share
• favorite_border

• share
• favorite_border

Two renowned research centers at University of California San Diego are joining forces to take a deeper look at how components of human milk and the microbiome can change the course of therapeutics for infant and adult diseases.

• share
• favorite_border

Diagnoses of autism spectrum disorder (ASD) by trained professionals in children as young as 14 months are remarkably stable, suggesting that accurate screening and earlier treatment is feasible, report scientists at University of California San Diego School of Medicine.

• share
• favorite_border

Researchers at University of California San Diego School of Medicine found using blood thinners in patients with worsening heart failure, coronary artery disease and irregular heart rhythms was associated with a reduced risk of thromboembolic events, such as stroke and heart attack.

• share
• favorite_border

University of California San Diego School of Medicine researchers and collaborators describe a new set of “rules” that predict how the tissue of origin influences critical aspects of the genetic makeup of tumors, with potentially important therapeutic implications.

• share
• favorite_border

University of California San Diego School of Medicine researchers found that treating patients with personalized precision medicine that combined therapies to target multiple alterations improved outcomes in patients with therapy resistant cancers.

• share
• favorite_border

UC San Diego Health has invested in a new robotic technology to benefit patients in need of restorative spine surgery. This technology enables minimally invasive spine surgery, the benefits of which include potential for shorter operations, less anesthesia, smaller incisions and reduced blood loss.

• share
• favorite_border

• share
• favorite_border

The NASA Twins Study is the most comprehensive integrated multi-omics, molecular, physiological, and behavioral analysis of how the human body responds to space flight to date. Study results were published in the April edition of Science.

• share
• favorite_border

Treatment with a choline kinase inhibitor prompts immune cells to clear away damaged mitochondria, thus reducing NLRP3 inflammasome activation and preventing inflammation.

• share
• favorite_border

• share
• favorite_border

Patients who suffer from VF live in constant fear of triggering a cardiac event, which can only be treated with an automated external defibrillator and which can become fatal in mere seconds. But a new procedure developed at UC San Diego Health is now presenting an alternative: a curative procedure.

• share
• favorite_border

An international team of scientists led by researchers at University of California San Diego School of Medicine employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies – and thus vulnerabilities – of pancreatic cancer stem cells.

• share
• favorite_border

Moores Cancer Center at UC San Diego Health treats the first patient treated for cancer with a human-induced pluripotent stem cell (iPSC)-derived cell therapy called FT500. Dan Kaufman collaborated with Fate Therapeutics to bring the iPSC-derived natural killer cell cancer immunotherapy to patients.

• share
• favorite_border

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, report on a novel four-year, randomized clinical trial evaluating different home-based methods to assess cognitive function and decline in participants over the age of 75.

• share
• favorite_border

In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person’s stool microbes.

• share
• favorite_border

• share
• favorite_border

UC San Diego School of Medicine research sets the stage for clinicians to potentially one day use levels of a pancreatic cancer patient’s PHLPP1 and PKC enzymes as a prognostic, and for researchers to develop new therapeutic drugs that inhibit PHLPP1 and boost PKC as a means to treat the disease.