A biochemical mechanism that cells use to cope with hypoxia (lack of oxygen) actually cooperates with a less well-known mechanism that helps increase the expression of those hypoxia-sensitive genes, according to investigators at St. Jude Children's Research Hospital.
Disruption of the normal interaction between the genes PRODH and COMT contributes directly to major symptoms of schizophrenia by upsetting the balance of the brain chemicals glutamate and dopamine, according to a group of investigators.
The ability of the brain to transmit and process information requires a lifelong commitment to maintaining the integrity of synapses, according to investigators at St. Jude Children's Research Hospital and colleagues in Hokkaido University School of Medicine (Japan).
The Ink4c and Ptch1 genes collaborate to suppress the development of medulloblastoma, the most common pediatric brain tumor, according to investigators.
Brain tumors called ependymomas that occur in different parts of the central nervous system appear to arise from subpopulations of stem cells called radial glia cells (RGCs), according to investigators at St. Jude Children's Research Hospital.
Investigators at St. Jude Children's Research Hospital have demonstrated in laboratory studies a new treatment for the pediatric eye cancer retinoblastoma that appears to be more effective than the current standard therapy, and more likely to prevent the recurrence of this cancer.
Scientists at St. Jude Children's Research Hospital have discovered a death signal that brings about the death of Streptococcus pneumoniae (also known as pneumococcus) - a discovery that could lead to revolutionary new treatments for the killer bacteria.
A program proven to dramatically increase cure rates for pediatric cancer has been established in El Salvador by St. Jude Children's Research Hospital. The program will serve as a model for international outreach programs around the world.
Two lipoprotein receptors bind to the protein made by the reelin gene (which controls development of the brain and is associated with neurodegenerative disorders), St. Jude Children's Research Hospital scientists published in today's issue of Neuron.
The gene MRP4 appears to help T cells, key components of the human immune system, "pump out" certain anti-HIV drugs and may allow the development of drug-resistant strains of HIV, report a team of St. Jude Children's Research Hospital scientists in the September issue of Nature Medicine.
This week, the country's leading theological experts will convene with top cancer researchers to lend their perspective to moral, ethical, religious and scientific questions about new genetic and medical technology.
This week leading legal experts will convene with top cancer researchers at St. Jude Children's Research Hospital's symposium, "Ethical Boundaries in Cancer Genetics," to discuss "Gene Therapy in Cancer Treatment and Prevention," the third plenary session of the symposium.
This week, the country's leading legal and theological experts together with top cancer researchers will convene to discuss other moral, ethical, religious and scientific questions at the "Ethical Boundaries in Cancer Genetics" symposium hosted by St. Jude Children's Research Hospital in Memphis, Tennessee on May 26-29.
The country's leading legal and theological experts and cancer researchers will discuss and argue the ethical and practical issues of genetic screening, susceptibility and new therapies as they relate to cancer research at symposium at the Memphis Marriott-Downtown Hotel in Memphis, Tenn.
12 sessions exploring the ethics of cancer "Ethical Boundaries in Cancer Genetics," organized by St. Jude Children's Research Hospital May 26-29.
Researchers at St. Jude Children's Research Hospital have reached a milestone in the treatment of the most common form of pediatric cancer, acute lymphoblastic leukemia (ALL), and efforts are already underway to test a new treatment protocol that researchers hope will lead to even higher cure rates for this once-deadly disease, they reported in the Aug. 27 New England Journal of Medicine.
Robert G. Webster, Ph.D., who played a key role in helping to identify the new Hong Kong influenza virus (H5N1), will be available to the media Monday morning, December 15, via telephone conference call following recent news of additional infections and a second death. Call 800-289-0730 and give the confirmation number 410960, or ask for the St. Jude conference.
A pediatric cure rate of 90 percent should be possible early next century according to the world's top treatment and research specialists associated with acute lymphoblastic leukemia (ALL) meeting at St. Jude Children's Research Hospital.
While identifying a new cancer-fighting tumor suppressor gene called ARF, scientists at St. Jude Children's Research Hospital have made another, potentially more far-reaching discovery, that a single genetic locus called INK4a encodes protein products that regulate the most frequently targeted biochemical pathways in human cancers.
Research over the past 10 years has shown that acute leukemia is in fact a genetic disorder. It arises when genes essential to correct blood cell function are not expressed at the appropriate times. In many cases, the failure of gene expression can be traced to an altered protein known as a transcription factor.
Doctors at St. Jude Children's Research Hospital today announced new brain tumor research protocols they hope will improve survival rates and reduce side effects of radiation therapy among pediatric cancer patients.
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