Using powerful gene-analysis tools, researchers have discovered mutations in two related genes, ARID1A and ARID1B, that are involved in the most aggressive form of the childhood cancer neuroblastoma.
Researchers have discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, including outcomes such as adult height, risk of type 2 diabetes and adult blood pressure.
While pediatricians and ER physicians value their role in concussion management, a study of their knowledge, practices and attitudes points to the need for training and tools to support optimal patient care. The study, released today in Pediatrics, served as a catalyst for CHOP to create a “medical home” model for managing pediatric concussion.
The Center for Autism Research at The Children’s Hospital of Philadelphia (CHOP) is among The Children’s Miracle Network’s (CMN) “Ultimate Gift” beneficiaries for its social media-based holiday fundraising program, Give Miracles. In addition to its social media presence, ads announcing the campaign for CHOP will run in the Wall Street Journal on November 10th and 24th, and on December 1st and 15th.
Scientists from The Children's Hospital of Philadelphia presented new findings this week in pediatric heart disease. Topics included racial disparities in sudden cardiac death, novel 3D imaging and concurrent organ transplants.
A large international study has identified three new gene variants associated with body mass index (BMI) levels in adults. Genome scientists who led the study say the findings may provide fundamental insights into the biology of adult obesity.
New research from The Children's Hospital of Philadelphia links teen driver "decal law" to a reduction in teen car crashes.
CHOP tool helps parents identify values, priorities; prompt doctors to ask helpful questions.
Parents with a higher number of stressors in their lives are more likely to have obese children, according to a new study. Children also ate fast food more often if their parents perceived themselves as stressed.
In the largest-ever genetic study of cholesterol and other blood lipids, an international consortium has identified 21 new gene variants associated with risks of heart disease and metabolic disorders.
After a series of Philadelphia hospitals started closing their maternity units in 1997, infant mortality rates increased by nearly 50 percent over the next three years.
The Children’s Hospital of Philadelphia and BGI announced today that the BGI@CHOP Joint Genome Center will begin to offer clinical next-generation sequencing services at CHOP, in a CAP/CLIA-compliant environment.
CHOP achieved high placements in the IT rankings announced this week by InformationWeek. The industry publication recognized the hospital's innovations in streamlining secure access to children's electronic health records.
A national study conducted from The Children’s Hospital of Philadelphia (CHOP) found a 62 percent increase in the number of Medicaid-enrolled children ages 3 to 18 taking antipsychotics, reaching a total of 354,000 children by 2007. Increased antipsychotic use was observed across a wide range of mental health diagnoses, and was particularly high for children with ADHD or conduct disorder, although the FDA has not approved the drugs to treat these conditions in children.
Expectant mothers who learn from prenatal diagnosis that they are carrying a fetus with a congenital heart defect (CHD) commonly suffer post-traumatic stress, depression and anxiety. However, a healthy relationship with one’s partner and positive coping mechanisms can reduce this intense stress, according to new research from the Cardiac Center of The Children’s Hospital of Philadelphia.
Research will focus on finding earliest behavioral and biological signs of autism.
Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma, as well as contributing to a tumor's progression. The findings may suggest future targets for new therapies.
Researchers have identified a key gene that, when mutated, causes the rare multisystem disorder Cornelia deLange syndrome. Mutations in the HDAC8 gene disrupt genetic transcripton, impairing early development.
Donna McDonald-McGinn, M.S., CGC, program director of the “22q and You” Center at The Children’s Hospital of Philadelphia, received the Angelo DiGeorge Medal of Honor at the 8th Biennial International 22q11.2 DS Conference.
A pilot study in adolescents and adults has found that an investigational drug shows promise as the first potential medical treatment for children with the severest type of congenital hyperinsulinism.
Premature babies are more likely to survive when they are born in high-level neonatal intensive care units (NICUs) than in hospitals without such facilities, and this benefit is considerably larger than previously reported.
In the largest study to examine the impact of the recession on child abuse, researchers at The Children’s Hospital of Philadelphia’s (CHOP) PolicyLab detected a significant increase in children admitted to the nation’s largest children’s hospitals due to serious physical abuse over the last decade. The CHOP findings, based on data from 38 children’s hospitals, contradict national child welfare data, which show a decline in child physical abuse over the same period.
Douglas C. Wallace, Ph.D., director of the Center for Mitochondrial and Epigenomic Medicine at The Children’s Hospital of Philadelphia, will receive the 2012 Genetics Prize of The Gruber Foundation. This prestigious international award—a $500,000 prize—recognizes Wallace’s pioneering scientific investigations of the wide-ranging role of mitochondria in the development of disease and as markers of human evolution.
BGI, the world’s largest genomics organization, and The Children’s Hospital of Philadelphia announced that they have jointly initiated the 1,000 Rare Diseases Project to accelerate gene discovery in rare diseases.
In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on chromatin looping, key biological events that may eventually be manipulated to provide new disease treatments.
Researchers studying rare genetic disorders have uncovered insights into those diseases in biological structures that regulate chromosomes when cells divide.
A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma.
Sildenafil, also known as the erectile dysfunction drug Viagra, may give a boost to underdeveloped hearts in children and young adults with congenital heart defects.
Yaël P. Mossé, M.D., who cares for patients with cancer at The Children’s Hospital of Philadelphia, will receive the inaugural James B. Nachman ASCO Junior Faculty Award in Pediatric Oncology.
Researchers studying molecular signals that drive B cell lymphoma have found a key biological pathway leading to this type of cancer. The finding may help to break so-called "oncogene addiction" in treating this cancer.
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