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Small steps can equal big changes when it comes to diabetes. Stony Brook Medicine's Dr. Joshua Miller explains how to lower your risk for diabetes and pre-diabetes

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The discovery of an inhibitor of the Insulin Degrading Enzyme (IDE), a protein responsible for the susceptibility of diabetes because it destroys insulin in the body, may lead to new treatment approaches for diabetes.

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A Stony Brook University-led international research team has discovered how a cellular protein, STAT3, which is overactive in a majority of cancers, interferes with an antitumor mechanism in cells and therefore promotes the growth of cancer.

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Imagine cutting down the growth of cancer cells at their earliest stages. Research conducted by Stony Brook University is showing promise in this approach with a new class of compounds that disrupt cancer cell mitochondrial metabolism.

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Findings from a new global study suggest that estimates of gender-based violence (GBV) prevalence based on health systems data or on police reports may underestimate the actual total prevalence by 11- to 128-fold.

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An analysis of the femur of one of the oldest human ancestors reveals the six-million-year-old “Millenium Man” was bipedal but lived in the trees.The research could provide additional insight to the origins of human bipedalism.

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A team of Stony Brook University researchers has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment.

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Sharon Nachman, MD, a pediatric HIV specialist at Stony Brook Children’s Hospital, is a co-author of new NIH-issued guidelines for the prevention, treatment and management of opportunistic infections in HIV-infected children.

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Despite nearly universal awareness of report cards on risk-adjusted mortality rates of individual cardiac surgeons, cardiologists in New York State do not use these reports when making patient referral decisions.

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A study of two sets of 894 matched Emergency Department (ED) patients presenting with chest pain revealed that the use of coronary computed tomographic angiography (CCTA) led to fewer hospital admissions and shorter ED stays. According to lead researcher Michael Poon, MD, of Stony Brook University School of Medicine, the findings provide evidence that CCTA offers an alternative means of improving the triage of chest pain patients. The paper, “Associations Between Routine Coronary Computed Tomographic Angiography and Reduced Unnecessary Hospital Admissions, Length of Stay, Recidivism Rates, and Invasive Coronary Angiography in the Emergency Department Triage of Chest Pain,” is published online in the August 6 issue of the Journal of the American College of Cardiology.

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Well-rested teenagers tend to make more healthful food choices than their sleep-deprived peers, according to a study led by Lauren Hale, PhD, Associate Professor of Preventive Medicine at Stony Brook University School of Medicine. The finding, presented at SLEEP 2013, the annual meeting of the Associated Professional Sleep Societies, may be key to understanding the link between sleep and obesity.

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Bed bugs now need to watch their step. Researchers at Stony Brook University have developed a safe, non-chemical resource that literally stops bed bugs in their tracks. This innovative new technology acts as a man-made web consisting of microfibers 50 times thinner than a human hair which entangle and trap bed bugs and other insects. This patent-pending technology is being commercialized by Fibertrap, a private company that employs non-toxic pest control methods.

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Greeted by their families, supporters and a shining display of 6,000 pinwheels, Christopher Pendergast, a 20-year ALS (amyotrophic lateral sclerosis) patient and advocate, and other ALS patients, rode onto the Stony Brook University Campus for the annual “Ride for Life” Celebration and Remembrance Ceremony, marking the halfway point of the ride from Southold to Manhattan, which concluded May 18. The pinwheels represented the American lives lost each year to ALS, or Lou Gehrig’s disease. During the ceremony, Pendergast presented a check on behalf of the Ride for Life for $150,000 to Stony Brook University to support ALS research at Stony Brook Medicine and the Christopher Pendergast ALS Center of Excellence, the only ALS Association-certified center on Long Island.

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The Simons Center for Geometry and Physics is hosting the third annual String-Math Conference 2013 June 17 to June 21. The Conference brings together mathematicians and physicists who work on ideas related to string theory.

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Stony Brook University received a $1 million donation from Dr. Deng Wei to establish the Yang Chen Ning – Deng Wei Endowed Chair in Physics and Astronomy. The gift was announced at a formal donation ceremony that took place in Beijing, China on May 17 attended by Nobel Laureate Dr. C.N. Yang, Dr. Deng, founder and chairman of Bright Oceans Corporation based in Beijing, Dr. Hong Chen (’91), founder of the Hina Group, and Dr. Samuel L. Stanley Jr., President of Stony Brook University.

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The results of a phase 1/2 clinical trial in Europe of an investigational Lyme disease vaccine co-developed by researchers at Stony Brook University, Brookhaven National Laboratory, and at Baxter International Inc., a U.S. based healthcare company, revealed it to be promising and well tolerated, according to a research paper published online in The Lancet Infectious Diseases. The vaccine was shown to produce substantial antibodies against all targeted species of Borrelia, the causative agent of Lyme disease in Europe and the United States. Baxter International conducted the clinical trial of the vaccine.

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A team of researchers led by Artem R. Oganov, a professor of theoretical crystallography in the Department of Geosciences, has made a startling prediction that challenges existing chemical models and current understanding of planetary interiors — magnesium oxide, a major material in the formation of planets, can exist in several different compositions. The team’s findings, “Novel stable compounds in the Mg-O system under high pressure,” are published in the online edition of Physical Chemistry Chemical Physics. The existence of these compounds — which are radically different from traditionally known or expected materials — could have important implications.

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Dozens of cutting edge technology energy entrepreneurs from across New York State and the country have the unique opportunity to be mentored, learn about development opportunities and pitch their business plan to venture capitalists, business leaders, “angel” investors, and legal and financial advisors when they convene at Advanced Energy 2013 April 30 to May 1 in New York City.

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Projected to start in the second half of 2013, researchers at Stony Brook University plan to begin phase IIa placebo-controlled clinical trials using a drug treatment method developed here to treat cellulite. The treatment method is licensed to BioSpecifics Technologies Corp. (“BSTC”), sublicensed to Auxilium Pharmaceuticals, Inc., (“Auxilium”), and uses clostridial collagenase histolyticum (“CCH”), an injectable form of the enzyme collagenase.

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For the millions of Americans who rely on pain medications for neuralgia, a condition where nerves damaged by surgery, traumatic injury, or diseases such as diabetes cause chronic pain, an emerging non-pharmacological treatment may offer relief. By placing a tiny ball of ice on damaged nerves by way of a minimally invasive interventional radiology treatment called cryoneurolysis, William Moore, MD, a thoracic interventional radiologist at Stony Brook University School of Medicine, is able to safely short circuit chronic pain caused by nerve damage.

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For 11-year-old Veronica Franco, music has always been a passion. The Rocky Point, N.Y., native loves playing cello and singing in the choir at Rocky Point Middle School. Her outstanding singing ability has garnered her recognition: Veronica earned a coveted spot in the Metropolitan Youth Orchestra (MYO) children’s chorus and performed at Carnegie Hall on March 16.

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Charles A. Gargano, former U.S. Ambassador to Trinidad and Tobago and long-time friend of Stony Brook University, has agreed to establish the Ambassador Charles Gargano Chair in Advanced Cardiovascular Imaging at Stony Brook Medicine. The $750,000 gift will be matched dollar for dollar by the Simons Foundation Challenge and Jim and Marilyn Simons, creating a $1,500,000 philanthropic impact.

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Specialists at Stony Brook Medicine’s Cerebrovascular and Stroke Center (CVC) are treating patients with a new generation of blood clot removal devices that show promise in successfully revascularizing stroke patients, including those with large vessel blockages. The Solitaire Flow Restoration Device and the Trevo device, approved by Food and Drug Administration (FDA) in 2012 to treat stroke caused by the sudden obstruction of a brain blood vessel (acute ischemic stroke) showed improved results over a previous standard and first generation clot-removal device in clinical trials.

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Data from the largest multicenter study accessing cognitive functioning in children with multiple sclerosis (MS) reveals that one-third of these patients have cognitive impairment, according to a research paper published in the Journal of Child Neurology. Led by Lauren B. Krupp, MD, Director of the Lourie Center for Pediatric Multiple Sclerosis at Stony Brook Long Island Children’s Hospital, the study indicates that patients experience a range of problems related to cognition.

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Low-intensity vibrations led to improvements in the immune function of obese mice by restoring B and T-cell populations and thereby diminishing consequences of obesity, according to a Stony Brook University study.

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Stony Brook University School of Medicine researchers have found that children’s brains are more affected by an inhaled anesthetic than an intravenous anesthetic with increased levels of brain lactate.

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Stony Brook cancer specialist solves a diagnostic puzzle that appeared to be brain cancer.

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Researchers from Stony Brook University have developed a high-resolution, 3D optical Doppler imaging tomography technique that captures the effects of cocaine restricting the blood supply in vessels of the brain.

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A series of rehabilitation studies published in Archives of Physical Medicine & Rehabilitation demonstrate that innovative treatments for individuals with spinal cord injuries can lead to functional improvements.

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A new study by Dr. Benjamin J. Luft of Stony Brook University School of Medcicine and colleagues will explore the role genetics may play in the development of PTSD and respiratory illness in 9/11 WTC responders.

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– A team of scientists that used a method of analyzing proteins from samples is the first to detect an immune response from a 500-year-old Incan mummy. Completed at the Proteomics Center, Stony Brook University, the process led to the first positive evidence of active pathogenic infection in an ancient sample of a 15-year-old girl who exhibited an immune response consistent with chronic respiratory infection. Their findings are reported in the PLoS One article “Detecting the Immune System Response of a 500 Year-old Inca Mummy.”

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Research led by Yi-Xian Qin, PhD, Professor, Department of Biomedical Engineering, and Director of the Orthopaedic Bioengineering Research Laboratory at Stony Brook University, demonstrated that the use of medium-intensity focused ultrasound on osteoblasts, known as bone-forming cells, stimulates the mobility of the cells and triggers calcium release, a process that promotes growth. The technique could provide a foundation for a method to develop non-pharmacologic treatments of osteoporosis, fractures, and other conditions involving bone loss. The team’s research findings are detailed online in the PLoS One article “Mechanobiological Modulation of Cytoskeleton and Calcium Influx in Osteoblastic Cells by Short-Term Focused Acoustic Radiation Force.”

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The gene p53 is the most commonly mutated gene in cancer. p53 is dubbed the “guardian of the genome” because it blocks cells with damaged DNA from propagating and eventually becoming cancerous. However, new research led by Ute M. Moll, M.D., Professor of Pathology at Stony Brook University School of Medicine, and colleagues, uncovers a novel role for p53 beyond cancer in the development of ischemic stroke. The research team identified an unexpected critical function of p53 in activating necrosis, an irreversible form of tissue death, triggered during oxidative stress and ischemia. The findings are detailed online in Cell.

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Stony Brook University, through its School of Health Technology and Management (SHTM), is collaborating with Los Angeles-based NextStep Fitness with the intention to build the organization’s first fitness and wellness facility in New York State for people with paralysis and spinal cord injuries. NextStep founder Janne Kouri, a former Georgetown University star football player paralyzed in a swimming accident in 2006, and Stony Brook University President Samuel L. Stanley Jr., M.D., will announce the plan at NextStep’s “Help Make a Difference” Benefit at the Tribeca Cinemas in Manhattan on June 7.

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Christopher Pendergast, a 19-year ALS (amyotrophic lateral sclerosis) patient and advocate, along with ALS patient Steve DePascale, their families friends and other supporters, led the charge as they rode onto the Stony Brook University campus on June 2 to a display of 6,000 flickering pinwheels. The pinwheels represented the American lives lost each year to ALS, or Lou Gehrig’s disease. During Stony Brook’s “Ride for Life” Celebration and Remembrance Ceremony, Pendergast presented a check for $1 million from the Ride for Life organization to Stony Brook. He also received a gift from Dr. Samuel L. Stanley Jr., President Stony Brook University – a Seawolves baseball jersey with Pendergast’s name and Lou Gehrig’s number 4 on it. The Remembrance Ceremony was held on the same day that Yankee great Lou Gehrig passed away from ALS in 1941 shortly before turning 38.

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Aristolochic acid (AA), a component of a plant used in herbal remedies since ancient times, leads to kidney failure and upper urinary tract cancer (UUC) in individuals exposed to the toxin.

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An analysis of a nationally representative sample of 710 adult respondents reveals that the public is less willing to pay to avoid mental illnesses compared to paying for treatment of medical conditions.