Cleveland Clinic has been designated a Rare Disease Center of Excellence by the National Organization for Rare Disorders (NORD). The new Cleveland Clinic Center for Rare Diseases is one of 40 U.S. academic medical centers selected to join the first-of-it-kind national network dedicated to diagnosing, treating and researching all rare diseases.
Findings from a Cleveland Clinic-led study showed for patients with community-acquired pneumonia treated with intravenous (IV) antibiotics, earlier switching to oral antibiotics in clinically stable patients was associated with shorter duration of antibiotics and hospital stay.
A Cleveland Clinic landmark study on obesity and cancer, led by Ali Aminian, M.D., director of Cleveland Clinic’s Bariatric & Metabolic Institute, was recognized with a 2023 Top Ten Clinical Research Achievement Award by the Clinical Research Forum (CR Forum). The award-winning paper, the SPLENDID study that was published in JAMA, also received an additional recognition as a Distinguished Clinical Research Awardee.
Cleveland Clinic researchers found 41% of patients with long COVID, had moderate to severe sleep disturbances. The retrospective analysis also identified risk factors for moderate to severe sleep disturbances, including race, hospitalization for COVID-19, greater anxiety severity and fatigue. After adjusting for demographics, Black patients were three times more likely to develop these sleep disturbances. The findings were published in Journal of General Internal Medicine.
Cleveland Clinic has opened a new state-of-the-art cancer facility, named the Fatima bint Mubarak Center, at Cleveland Clinic Abu Dhabi, located in the United Arab Emirates capital.
Cleveland Clinic has received a transformational philanthropic gift from the United Arab Emirates, in the name of H.H. Sheikha Fatima bint Mubarak, that will support global pathogen and cancer research.
The Patient-Centered Outcomes Research Institute (PCORI) has chosen Cleveland Clinic for a nationwide initiative to improve how healthcare systems translate research findings to clinical practice.
Cleveland: A self-administered screening tool, developed by Cleveland Clinic researchers, can effectively and efficiently assess cognition issues in older adults.
Supported by a new $3.14 million grant from the National Institutes of Health to Cleveland Clinic, researchers are using an emerging technology known as “digital twins” to better understand healthcare disparities based on where someone lives. Researchers from Cleveland Clinic and MetroHealth aim to use this information to develop strategies designed to reduce these disparities in health outcomes.
Cleveland Clinic London will open a new medical outpatient building at 77 Coleman Street in the City of London, Cleveland Clinic Moorgate Outpatient Centre, which will welcome patients in autumn 2023 for outpatient appointments, diagnostics (including MRI), and general practice appointments.
Cleveland Clinic performed 1,050 transplants in 2022, including heart, kidney, liver, intestine and lung transplants, as well as living donor transplantation for kidney and liver. That is up 1% from the number of transplants performed at Cleveland Clinic in 2021.
Heart disease is the No. 1 killer of women and men in the United States. It causes one in every four U.S. deaths.
Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.
Cleveland Clinic launched the Center for Infant and Maternal Health initiative to help reduce infant and maternal mortality in Cuyahoga, Lorain and Summit counties.
Cleveland Clinic and Vinmec Health System jointly announced that Vinmec Times City International Hospital has become a member of Cleveland Clinic Connected.
A new method of donor-lung distribution is projected to decrease the number of candidate deaths who are on the waitlist for lung transplant, according to a study by Cleveland Clinic and the U.S. Scientific Registry of Transplant Recipients (SRTR) published in The American Journal of Transplantation.
New research findings have revealed an underlying genetic cause for why some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but potentially life-threatening disease. The findings, published in Science, are the first potential genetic cause identified for MIS-C, a disease that typically occurs about four weeks after COVID-19 infection and has broad symptoms such as fever, vomiting and inflammation of the heart muscle that can lead to hospitalization. States have reported about 9,000 MIS-C cases, with 71 deaths, according to most recent Centers for Disease Control and Prevention numbers.
New research at Cleveland Clinic expands the link between what we eat and how the gut microbiome impacts our susceptibility to develop different diseases – in this case, how a specific gut microbe-generated byproduct is linked to heart failure risk.
Cleveland Clinic was awarded $5.5 million from the National Institutes of Health to develop a stem cell treatment for complex regional pain syndrome, a disease that causes debilitating chronic pain. The research shows long-term potential for providing patients suffering from chronic pain an alternative to addictive treatments like opioids.
As part of its continued efforts to ensure greater access to quality care for patients around the world, Cleveland Clinic is broadening its network of in-country representatives to five locations: Canada, China, Colombia, Ecuador and Mexico.
Antibiotics routinely used in ovarian cancer care indiscriminately kill gut bacteria, leading to faster cancer progression and lower survival rates, according to recent Cleveland Clinic research.
CLEVELAND - Considering how patients from different ethnic groups respond to the same drug could be crucial to finding new Alzheimer’s disease treatments – a disorder the Alzheimer’s Association previously deemed a “silent epidemic” among Black adults. A Cleveland Clinic-led study published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association showed that telmisartan, a drug currently prescribed for people with high blood pressure, is associated with a lower risk of Alzheimer’s specifically in Black patients over age 60. Insurance data from millions of adults over age 60 did not show the same potential effect in white patients.
Cleveland Clinic’s Lerner Research Institute was awarded a five-year $12 million grant by the National Cancer Institute, part of the National Institutes of Health, to define how cytokines - proteins produced during immune response - regulate inflammation and interact with cells and molecules surrounding tumors.
Cleveland Clinic and IBM have begun deployment of the first private sector onsite, IBM-managed quantum computer in the United States. The IBM Quantum System is to be located on Cleveland Clinic’s main campus in Cleveland. The first quantum computer in healthcare, anticipated to be completed in early 2023, is a key part of the two organizations’10-year partnership aimed at fundamentally advancing the pace of biomedical research through high-performance computing. Announced in 2021, the Cleveland Clinic-IBM Discovery Accelerator is a joint center that leverages Cleveland Clinic’s medical expertise with the technology expertise of IBM, including its leadership in quantum computing.
Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation. The study, published in Cell Reports Medicine, built on ongoing collaborative Cleveland Clinic research to support further investigation into metformin as a drug repurposing candidate. Researchers used advanced computation and genetic sequencing to determine that metformin’s targets overlap significantly with genes dysregulated in atrial fibrillation.
A Cleveland Clinic-led research team used artificial intelligence to map out hundreds of ways that the virus that causes COVID-19 interacts with infected cells. Through this analysis, they identified potential COVID-19 medicines within thousands of drugs already approved by the FDA for other treatments. The research focused on host-targeting therapies, which operate differently from other antivirals by disrupting the mechanisms viruses use to multiply and survive, rather than just blocking specific proteins within the cell. The research, published in Nature Biotechnology, presents a network called an “interactome,” the interactions between COVID-19 virus proteins and host cell proteins.
Cleveland: Findings from a Cleveland Clinic-led trial show that increasing the salt intake by mouth for patients who are hospitalized with heart failure undergoing aggressive diuretic therapy did not affect how much fluid they retain or their kidney function, indicating that salt intake for heart failure patients may not be as harmful as previously thought. Conversely, these new findings may challenge the common practice of salt restriction during hospital admission since that might not be as helpful.
Cleveland Clinic has been selected as a founding partner and the leading healthcare system in a new initiative meant to spur collaboration and innovation in the quantum computing industry. Based in Greater Washington, D.C., Connected DMV and a cross-sector coalition of partners are developing the new Life Sciences and Healthcare Quantum Innovation Hub to prepare the industry for the burgeoning quantum era and align with key national and global efforts in life sciences and quantum technologies.
The National Institutes of Health (NIH) awarded a $10.7 million five-year renewal grant to Cleveland Clinic to expand a national research consortium focused on improving the diagnosis and treatments for Dementia with Lewy Bodies. The Dementia with Lewy Bodies Consortium, established in 2017, centralized research efforts and created a national, coordinated registry for clinical data.
Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the National Institutes of Health to form one of three national centers as part of the newly established Radiation Oncology-Biology Integration Network (ROBIN).
Researchers from Cleveland Clinic’s Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a “priming signal” for the body to respond to a virus. These findings, published in Cell this week, potentially lay the groundwork for development of new anti-viral vaccines and treatments.
A new scientific statement from the American Heart Association (AHA) provides important guidance about sleep-disordered breathing (SDB), an often undiagnosed but prevalent health problem, and its association with development of cardiac arrhythmia. Published in Circulation, the comprehensive analysis was authored by a panel led by Cleveland Clinic experts Reena Mehra, MD, MS, and Mina Chung, MD, as chair and vice chair, respectively. The statement provides data showing the potential value of how SDB treatment affects cardiac arrhythmias beneficially and thereby can improve patient outcomes.
Cleveland Clinic has appointed Michelle Kang Kim, M.D., Ph.D., as chair of the Department of Gastroenterology, Hepatology and Nutrition with Cleveland Clinic’s Digestive Disease & Surgery Institute. Dr. Kim’s will start Aug. 1. She will succeed Miguel Regueiro, M.D., who has served as interim chair of the department since May 2021, following his appointment as chair of Cleveland Clinic’s Digestive Disease & Surgery Institute.
Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs.
New Cleveland Clinic research has uncovered key information about cellular interaction between tumor cells and normal tissue, providing better understanding of how therapeutic resistance develops. Findings published in Science Advances.
A new Cleveland Clinic study has identified geographic patterns of high and low mortality rates of young-onset colorectal cancer (yoCRC) in the United States, according to a research letter published in Gastroenterology. The findings will contribute to improved understanding of the underlying drivers of yoCRC mortality and may help to guide policy discussions surrounding screening guidelines and region-specific interventions.
A Cleveland Clinic study shows that among adults with obesity, weight loss achieved with bariatric surgery was associated with a 32% lower risk of developing cancer and a 48% lower risk of cancer-related death compared with adults who did not have the surgery. The research is published by JAMA.
Ted Ross, Ph.D., has been appointed Global Director of Vaccine Development at Cleveland Clinic. In this newly created role, he will lead the development of novel vaccine platforms for a variety of infectious diseases, including influenza, HIV and COVID-19. A highly renowned scientist with expertise in virology, vaccines, immunology and microbiology, Dr. Ross’ research focuses on the design of new vaccines and the implementation of new vaccine trials.
Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental “gene silencing” therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%. Findings from the “APOLLO Trial: Magnitude and Duration of Effects of a Short-interfering RNA Targeting Lipoprotein(a): A Placebo-controlled Double-blind Dose-ranging Trial” were presented today during a late-breaking science session at American College of Cardiology’s 71st Annual Scientific Session and simultaneously published online in the Journal of the American Medical Association.
Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.
Cleveland Clinic announced today the opening of Cleveland Clinic London Hospital, a 184-bed state-of-the-art hospital, at 33 Grosvenor Place in central London. The facility is the newest location in Cleveland Clinic’s expanding global footprint and the second in London, following the opening of Cleveland Clinic Portland Place Outpatient Centre in September 2021.
J. Joseph Melenhorst, Ph.D., has been appointed director of the new Cell Therapy and Immuno-Engineering Program, and Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.
Paul Marasco, Ph.D., Associate Staff, Department of Biomedical Engineering at Cleveland Clinic, will be honored with a 2022 Top Ten Clinical Research Achievement Award from the Clinical Research Forum (CR Forum), a non-profit membership association of top clinical research experts and thought leaders from the nation’s leading academic health centers. The awards honor groundbreaking achievements in clinical research from across the nation.
Cleveland Clinic has launched an innovative study exploring the link between epilepsy and stress, supported by a $5.5 million donation from the Charles L. Shor Foundation. The five-year clinical trial is the first of its kind to study and compare the effect of lifestyle interventions, such as yoga, music therapy and cognitive behavioral therapy, on seizure control. The research team will study the impact on seizure frequency as well as epilepsy-associated co-morbidities, such as depression, anxiety, cognitive function and quality of life. The team will follow 1,000 patients with difficult-to-treat epilepsy.
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