Collaborating with professor Tim Gilberger of the University of Hamburg in Germany, the researcher teams performed a screen of soil bacteria extracts for antimalarials and identified an extremely potent inhibitor of malaria development.
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Auditory alarms in hospitals can be vastly improved by changing the sound's amplitude envelope.
The study looked at patient outcomes from virtual care and remote automated monitoring (RAM) – video calls with nurses and doctors, and self-monitoring of vital signs using wearable devices. Half of 905 post-surgery patients at nine sites in Hamilton, Kingston, London, Ottawa and Edmonton in Canada were randomized to use technology at home.
Researchers at McMaster University who study the spread of infectious disease have found epidemic modelling can be used to determine what drives the popularity of hit songs, often described as contagious, infectious, or viral.
Researchers at McMaster University have developed a sophisticated new tool that could help provide early warning of rare and unknown viruses in the environment and identify potentially deadly bacterial pathogens which cause sepsis, among other uses.
Data from 32 randomized controlled trials showed that use of non-inhaled medical cannabis versus placebo resulted in small to very small improvements in pain relief, physical functioning, and sleep quality. There was no difference in emotional, social or role functioning.
A major study has found that convalescent plasma does not reduce the risk of intubation or death for COVID-19 patients. However, the study also revealed that the antibody profile in the blood of people who have had the virus is extremely variable and this may modify the response to the treatment.
Researchers ran the online workshops for 403 mothers with PPD between April and October last year. The workshops took place live through Zoom and included group exercises, role plays and modules on the causes of PPD, identifying and changing difficult thinking patterns, and strategies to help shift behaviours to improve mood and anxiety.
An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.
New research by McMaster University evolutionary biologist Rama Singh suggests there is a layer hidden in our cells that controls how genes interact, and how the many billions of possible combinations produce certain results.
A potentially game-changing treatment for people with, or at risk of, blood clots has been found effective by an international team of researchers led by McMaster University. Results showed one abelacimab injection prevents blood clots for up to a month after surgery, reducing the risk by about 80%.
A McMaster University team of researchers recently discovered how, exactly, the COVID-19 vaccines that use adenovirus vectors trigger a rare but sometimes fatal blood clotting reaction called vaccine-induced immune thrombotic thrombocytopenia or VITT.
Immunologists at McMaster University have discovered a previously unknown mechanism which acts like a spider web, trapping and killing pathogens such as influenza or SARS-CoV-2, the virus responsible for COVID-19.
Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumours.
Engineering, biochemistry and medical researchers from McMaster University have created a hand-held rapid test for bacterial infections that can produce accurate, reliable results in less than an hour, eliminating the need to send samples to a lab.
The treatment’s effectiveness was described in a report describing three Canadian patients who received the AstraZeneca vaccine, and who subsequently developed VITT. Two suffered clotting in their legs and the third had clots blocking arteries and veins inside their brain.
In a sample of nearly 500 young adults ranging in age from 18 to 25, researchers saw a reduction in problematic drinking and alcohol consequences during the initial phase of the pandemic for both men and women. This is in contrast to many anecdotal reports of increased drinking and increased household spending on alcohol during that time period. Additional findings showed increased rates of depression and anxiety symptoms among young women – increases that were not observed to a significant degree among male participants.
Findings are from a systematic review and meta-analysis. Data from 20 randomized controlled trials, which included a total of almost 12,000 patients, were analyzed in the study, providing strong and clear evidence in support of triple-drug therapy.
Five years after the disastrous wildfire in Fort McMurray, Alberta, researchers are warning that the complex role of peatlands, a factor critical to projecting the risk and behaviour of future fires, is missing from the forecasting model.
Kolb is research director at the Firestone Institute for Respiratory Health at McMaster and St. Joseph’s Healthcare Hamilton, as well as division director for respirology at the Department of Medicine. He is also the European Respiratory Journal’s chief editor.
A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits.
Using an epigenetic clock, the researchers looked at the genes of 45 of those who were ELBW babies along with 47 who were normal birth weight when they were age 30 to 35 to compare their biological age, controlling for chronic health problems and sensory impairments.
The study tracked 4,811 people in 27 countries who are living with atrial fibrillation and taking blood thinners. Consenting patients undertaking cardiopulmonary bypass surgery were randomly selected for the additional left atrial appendage occlusion surgery; their outcomes compared with those who only took medicine. They were all followed for a median of four years.
Researchers examined prenatal stool (meconium) samples collected from 20 babies during breech Cesarean delivery. By including only breech caesarean deliveries in healthy pregnant women they were able to avoid the transmission of bacteria that occurs naturally during a vaginal birth.
The international guideline panel included 22 health-care professionals, school administrators, and parents of children with and without food allergy, along with a team of six researchers with methodology expertise. A systematic literature review of practices for managing food allergy in schools found a lack of high-quality evidence, so the guideline recommendations are graded as conditional.
McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer.
A new grant is helping McMaster University engineers and a Toronto precision-medicine diagnostics company to get infection-testing technology to market while generating opportunities for students.
Ontario doctors are still hesitant to prescribe medical cannabis to patients suffering long-term pain 20 years after it was first introduced, says a new study carried out at McMaster University.
The pandemic has created a paradox where mental health has become both a motivator for and a barrier to physical activity.
People need to rethink what they stock in their home cabinets as allergy medicines, what hospitals keep on formulary, and what policymakers recommend. The message needs to get out. This publication is on time for the spring allergy season and as COVID vaccines roll out, for which rashes are common and antihistamines can be helpful
AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. In this research, the team identified a critical protein structure on the surface of the bacteria that allow them to grow in biofilms.
The information comes from the diets and health outcomes of 134,297 people from 21 countries spanning five continents, who were tracked by researchers for data on meat consumption and cardiovascular illnesses. After following the participants for almost a decade, the researchers found consumption of 150 grams or more of processed meat a week was associated with a 46 per cent higher risk of cardiovascular disease and a 51 per cent higher risk of death than those who ate no processed meat. However, the researchers also found moderate levels of consumption of non-processed meats had a neutral effect on health.
Blood from critically ill COVID-19 patients contains antibodies that can contribute to clotting. These antibodies form immune complexes that activate platelets, the cells that lead to blood clot formation. Some blood-thinner medications can block these immune complexes and potentially reduce clots.
The study used data collected from 44,817 participants enrolled in the Canadian Longitudinal Study on Aging (CLSA), a large, national population-based study of health and aging. The participants completed questionnaires about adverse childhood experiences through telephone and face-to-face interviews between 2015 and 2018.
The study will involve more than 2,000 residents, staff, and visitors of long-term care homes in Ontario over the course of a year. Blood and saliva will be examined.
An analysis of several large studies involving participants from more than 60 countries, spearheaded by researchers from McMaster University, has found that eating oily fish regularly can help prevent cardiovascular disease (CVD) in high-risk individuals, such as those who already have heart disease or stroke.
The study, involving 281 Ontario children, found that 85.7% of those who received the short course of antibiotics and 84.1% of those who received the longer course of medication were cured two to three weeks later.
Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded.
A total of 137,851 people aged 35 to 70 years old were followed for a median of 9.5 years through the Population Urban and Rural Epidemiology (PURE) study run by the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences.
The research team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results.
The McMaster research team is partnering with research clinic Cardresearch and the Pontifical Catholic University of Minas Gerais in Brazil as well as the University of Stellenbosch in South Africa on an ongoing clinical trial established to answer multiple questions of drug effectiveness over time.
Neuroscientists at McMaster University have found a link between children who are at risk for developmental coordination disorder (DCD), a common condition that can cause clumsiness, and difficulties with time perception such as interpreting changes in rhythmic beats.
Researchers at Canada's McMaster University have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
For the study 40 infants of women diagnosed with postpartum depression were matched with 40 infants of non-depressed mothers on infant age, gender and socioeconomic status. The mothers with postpartum depression received nine weeks of group CBT. The infants were all tested before the treatment and nine weeks later, including a questionnaire on the infant behaviour completed by the mother and her partner.
Researchers at Canada's McMaster University have developed a new form of cultivated meat using a method that promises more natural flavour and texture than other alternatives to traditional meat from animals.
A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body.
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