Children’s Hospital of Philadelphia (CHOP) has launched the Food Allergy Bravery (FAB) Clinic to help children with a phobia of anaphylaxis. This revolutionary clinic, housed within the Food Allergy Center, is the first in the world to bring together psychologists and food allergy experts to treat food allergic children with severe phobia of anaphylaxis.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients’ mutations and gene expression profiles to develop a comprehensive list of potentially cancer-causing mutations.
As the COVID-19 pandemic spread across the United States, governments at the state and local levels issued emergency declarations and shut down schools. With no treatment and no vaccine, this was seen as the best way to stop the spread of the SARS-CoV-2 virus. Researchers from Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania’s Perelman School of Medicine have conducted one of the first studies to measure the efficacy of social distancing in the early days of the COVID-19 pandemic. They found that states that were slow to implement such orders saw higher COVID-19 death rates.
A team of researchers from Children’s Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders.
The National Institutes of Health (NIH) announced today that researchers from Children’s Hospital of Philadelphia (CHOP) are among the recipients of a multi-million dollar grant that focuses on the use of genomics to improve risk assessment for diverse populations and integrate the findings into clinical care.
A team of researchers from Children’s Hospital of Philadelphia (CHOP) has demonstrated how to easily and effectively monitor for seizures in newborn infants, catching more instances than typical methods and improving the quality of care for infants in hospitals that lack the on-site resources to detect these seizures.
The number of patients visiting the emergency department (ED) for asthma treatment dropped by 76% in the first month of the COVID-19 pandemic, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The proportion of ED visits that led to a patient being hospitalized also decreased over this period, suggesting the decrease in overall visits was not solely due to patients avoiding the hospital due to the pandemic or delays in care for less serious asthma events.
As the COVID-19 pandemic sent entire communities into lockdown, doctors quickly adopted telehealth strategies without knowing whether they would be effective or feasible. Now, a new study from the Division of Neurology at Children’s Hospital of Philadelphia (CHOP) shows that for pediatric neurology care, the transition was very successful even in a short period of time and may provide guidance on the future of pediatric care after the pandemic subsides.
Cancer researchers at Children’s Hospital of Philadelphia (CHOP) have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus. Using this strategy, the researchers believe a resulting vaccine would provide protection across the human population and drive a long-term immune response.
Universally screening pediatric patients for COVID-19 before they undergo surgical procedures has allowed hospitals to improve safety by identifying all patients who test positive for the virus, half of whom have no symptoms, according to new research led by Children’s Hospital of Philadelphia (CHOP). The study, which analyzed universal screening procedures at CHOP and two other major children’s hospitals, found that screening patients for COVID-19 allowed hospitals to ensure patients and physicians were not exposed to the virus.
In a new study, researchers at Children’s Hospital of Philadelphia (CHOP) have performed the most comprehensive characterization of elementary school-age concussions to date, revealing an opportunity to improve outcomes for this age group through more consistent visio-vestibular assessments at the initial health care visit.
COVID-19 social distancing measures, including the closure of schools and parks and the indefinite cancellation of team sports, have led to a nearly 60% decrease overall in pediatric fractures but an increase in the proportion of fractures sustained at home, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The findings, published in the Journal of Pediatric Orthopaedics, suggest a need for increased awareness of at-home safety measures.
A primary care-based intervention to promote parent-teen communication led to less distress and increased positive emotions among adolescents, as well as improved communication for many teens, according to a new study by researchers at the Center for Parent and Teen Communication at Children’s Hospital of Philadelphia (CHOP). The findings, which were published today in The Journal of Pediatrics, highlight the potential impact of engaging parents in the primary care setting to improve parent-teen communication, which could lead to better adolescent health outcomes.
Children in rural communities are 1.7 times more likely to undergo an amputation after a lawnmower injury than children in urban communities, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The researchers also found that although lawnmower injuries are prevalent throughout the United States, children in Southern and Midwestern states account for more than 80% of pediatric lawnmower injuries.
The cardioprotective drug dexrazoxane preserved cardiac function in pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML) without compromising overall patient survival and potentially improving it, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The results suggest dexrazoxane should be considered for cardioprotection in all pediatric patients undergoing standard chemotherapy for AML.
Monitoring blood oxygen levels with continuous pulse oximetry is being overused in infants with bronchiolitis who do not require supplemental oxygen, according to a study by researchers at Children’s Hospital of Philadelphia (CHOP). The researchers found the use of continuous pulse oximetry occurred frequently and varied widely among hospitals in their sample, despite national recommendations advising against the practice.
A team of researchers at Children’s Hospital of Philadelphia (CHOP) has characterized how the gut microbiome develops in the first hours of infancy, providing a critical baseline for how changes in this environment can impact health and disease later in life.
Researchers at Children’s Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target.
Hoping to refine the usefulness of RNA sequencing, a team of researchers reviewed a database of RNA sequencing results in non-clinically-accessible tissues from organs like the brain and heart. This helped them identify differences between tissues that were well expressed to help identify when clinically-accessible tissues like blood and skin samples are most useful and when they are not.
A new study led by researchers at Children’s Hospital of Philadelphia (CHOP) shows that a set of simple questionnaires can help clinicians and families better evaluate the quality of life of people diagnosed with autism spectrum disorder (ASD). The newly-developed tool is designed for children, adolescents, and adults on the autism spectrum, and early findings show where clinicians can learn more about how to support the needs of autistic individuals by directly asking them these critical questions.
In an analysis of 2019 mass shootings and hospital locations, researchers at Children’s Hospital of Philadelphia (CHOP) found that the closest hospital to more than 70% of mass shootings was a non-trauma center, where sudden, high casualty loads were more likely to overwhelm capacity and trauma-specific care options may have been limited. They also found that in more than half of mass shooting events, the nearest pediatric trauma center was more than 10 miles away.
An increased awareness of concussion risks in young athletes has prompted researchers to use a variety of head impact sensors to measure frequency and severity of impacts during sports. A new study from Children’s Hospital of Philadelphia (CHOP) shows these head sensors can record a large number of false positive impacts during real game play. The CHOP team’s study emphasizes that an extra step to video-confirm the sensor data is essential for research and for use of this data in injury prevention strategies for player safety.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a novel treatment for sepsis – one of the leading causes of hospital death – that enhances the body’s bacteria-capturing neutrophil extracellular traps (NETs) so that they more effectively capture infectious bacteria, resist degradation, and improve sepsis outcomes and survival.
Researchers at Children’s Hospital of Philadelphia (CHOP) have found that children with a rare food allergy known as food protein-induced enterocolitis syndrome, or FPIES, have a significantly higher chance of being diagnosed with other allergic conditions, including eczema, traditional food allergy and asthma. But the researchers also found that FPIES did not directly cause those other allergies.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a novel computational algorithm to track the epidemiology of pediatric sepsis, allowing for the collection of more accurate data about outcomes and incidence of the condition over time, which is essential to the improvement of care.
In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon – in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited clinical information.
In a special report published today in the journal Pediatrics, Roberts Individualized Medical Genetics Center researchers, physicians, and genetic and financial counselors describe the success of the model, their plans to build on that success for the future, and the important lessons learned from their first four years in operation.
A multi-institutional group of researchers led by Children’s Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at the University of California, Los Angeles (UCLA), was published today in the Proceedings of the National Academy of Sciences.
Adolescents with a history of attention-deficit/hyperactivity disorder (ADHD) are at an increased risk for a multitude of adverse outcomes, including sexually-transmitted infections (STIs), mental health conditions, and car accidents. Researchers from Children’s Hospital of Philadelphia (CHOP) wanted to better understand how primary care doctors addressed these risks with patients as they transitioned from childhood to young adulthood. They found that although doctors generally discuss depression, substance abuse, and suicide risk with patients who have a history of ADHD, they rarely discuss safe driving with them and most of the time they do not monitor patients for risky sexual behavior.
The Pennsylvania Pediatric Medical Device Consortium (PPDC) has announced its latest round of seed grants to companies developing medical devices for children. The Consortium chose four projects from eight finalists in a competition to receive seed grants of $50,000 each.
Poor sleep habits and sleep disorders are very common in early childhood, especially in children exposed to multiple family and environmental risks like parental depression and poverty, say researchers from Children’s Hospital of Philadelphia (CHOP) in a study recently published in the journal Sleep.
In a follow-up to the landmark 2011 study that demonstrated prenatal surgery for spina bifida has measurable benefits over surgery after birth for one of the most disabling neural tube defects, researchers have published new findings. These findings show significant physical and emotional benefits a decade later in school-age children who received corrective surgery in the womb for myelomeningocele, the most severe form of spina bifida.
Bronchiolitis, a lung infection that is one of the most common reasons for hospitalizations in young children, is most prevalent during the winter months and is usually treated with albuterol delivered via inhalers, despite evidence showing no benefit in most patients. A multidisciplinary team of researchers from Children’s Hospital of Philadelphia (CHOP) redesigned the hospital’s standard treatment for the infection and reduced albuterol use without compromising care.
A large, multicenter study led by researchers at Children’s Hospital of Philadelphia (CHOP) compared the genomic data of more than 100,000 people of European ancestry and discovered how relatively rare, albeit recurrent, genetic variations can influence a variety of common diseases. In addition, existing drugs could be repurposed to target these conditions – ranging from autoimmune diseases to neuropsychological diseases and even cancer – now that the genetic underpinnings of these conditions are known.
A multi-center team of researchers led by Children’s Hospital of Philadelphia (CHOP) has discovered a genetic signature that could help distinguish an adult-onset form of diabetes sharing many type 1 diabetes (T1D) characteristics from pediatric-onset T1D, opening the door to potentially more straightforward diagnostic tests for the adult condition and improving responses by ensuring patients receive the most appropriate treatment.
Researchers have discovered key mechanisms and structural details of a fundamental biological process—how a cell nucleus and its chromosomal material reorganizes itself after cell division. The new findings in chromosomal architecture and function may offer important insights into human health and disease.
The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in pediatric cardiology.
A multicenter group of 41 hospitals led by researchers at Children’s Hospital of Philadelphia (CHOP) has confirmed that an improved method for predicting retinopathy of prematurity (ROP), a leading cause of blindness in children, was able to reduce the number of babies having invasive diagnostic examinations by nearly a third, while raising disease detection up to 100 percent.
A pediatric researcher has identified patterns of spinal curvature in younger children that may be likely to develop into scoliosis by adolescence. Accurately predicting scoliosis, a common, abnormal curvature of the spine, may set the stage for the first-ever methods to prevent the potentially disabling condition.
Stephan Grupp, MD, PhD, Chief of the Cell Therapy and Transplant Section in the Division of Oncology and Director of the Cancer Immunotherapy Program at Children’s Hospital of Philadelphia, has been elected into the National Academy of Medicine (NAM), effective Oct. 1, 2019.
Families dealing with the stress and frustration of their child’s overly picky eating habits may have a new addition to their parental toolbox. Pediatric researchers describe a brief group cognitive-behavioral therapy program that provides parents with specific techniques to improve their child’s mealtime behaviors and expand the range of foods their children will eat.
Beverly L. Davidson, PhD, director of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics at Children’s Hospital of Philadelphia, has been elected to the National Academy of Medicine. She is being recognized for her role in developing innovative therapies for fatal, inherited brain disorders.
Subtle changes in the DNA of mitochondria, the tiny power plants in cells, can have profound consequences for a patient’s health. Research on biological mechanisms suggests that relatively minor changes in mitochondrial energy flow and metabolism could offer significant future benefits to patients with complex diseases.
Researchers have identified a gene mutation that causes developmental delay, intellectual disability, behavioral abnormalities and musculoskeletal problems in children. Mutations in the NKAP gene cause the condition, called NKAP-related syndrome.
In the first large, real-world study of universal screening for autism spectrum disorder (ASD) in toddlers, researchers at Children’s Hospital of Philadelphia (CHOP) have found that the most widely used and researched screening tool is less accurate than shown in previous studies conducted in research laboratory settings. The new study also revealed significant disparities in detecting early autism symptoms in minority, urban and low-income children.
Researchers at Children’s Hospital of Philadelphia (CHOP)used state-of-the-art brain imaging techniques to determine how nonverbal or minimally verbal children who have autism spectrum disorder (ASD) processes auditory stimuli, which could have important diagnostic and prognostic implications across the autism spectrum.
Female athletes seek specialty medical treatment later than male athletes for sports-related concussions (SRC), and this delay may cause them to experience more symptoms and longer recoveries. The study raises the question of whether, in youth and high school sports, inequities in medical and athletic trainer coverage on the sidelines are contributing to delayed identification and specialized treatment of concussion for female athletes, leading to more symptoms and longer recovery trajectories.
Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development.
Scientists have discovered that a receptor on the surface of brain cells plays a key role in regulating how both animals and people respond to stress. The receptor may represent an important biomarker of post-traumatic stress disorder in humans and a potential target for future treatments.
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