By studying the genetic makeup of people who maintain clear arteries into old age, researchers led by UNC’s Jonathan Schisler, PhD, have identified a possible genetic basis for coronary artery disease (CAD), as well as potential new opportunities to prevent it.
New research from the Research Triangle suggests that variants in a gene called ankyrin-B – carried by millions of Americans – could cause people to put on pounds through no fault of their own.
In an analysis of the impact of parity laws published in JAMA Oncology, UNC Lineberger Comprehensive Cancer Center researchers and collaborators from Harvard Medical School report modest improvements in costs for many patients. However, patients who were already paying the most for their medications, saw their monthly costs go up.
Two studies by UNC Lineberger Comprehensive Cancer Center researchers reveal trends in the marketing practices, pricing, delivery methods and other features of online e-cigarette vendors.
UNC School of Medicine neuroscientists discover a long-distance brain circuit that controls the production of new neurons in the hippocampus. Research could have implications for understanding and treating many brain disorders, including epilepsy, schizophrenia, depression, and Alzheimer’s disease
Scientists publish experimental evidence that life on Earth originated in an intimate partnership between the nucleic acids and small proteins. Their “peptide-RNA” hypothesis contradicts the widely held hypothesis that life originated from nucleic acids and only later evolved to include proteins.
Veteran sailors know that rogue waves can rise suddenly in mid-ocean to capsize even the largest vessels. Now it appears that a similar phenomenon called shear shock wave occurs in the concussed brain. It may help explain why some head knocks cause so much more harm than others.
UNC and NC State researchers have developed artificial beta cells that automatically release insulin into the bloodstream when glucose levels rise. This work was done in lab experiments but could lead to a much more patient-friendly treatment than injections.
UNC-Chapel Hill maternal-fetal medicine specialist Dr. Tracy Manuck receives nearly $4 million to study health disparities and recurrent preterm birth.
Scientists understand new details about the development of Th17, a type of immune cell that is believed to play a complex role in cancer, and is also implicated in autoimmune diseases.
A study led by UNC Lineberger Comprehensive Cancer Center researchers found that preference for preserving sexual function was not strongly reflected in the treatment choices of men with low-risk prostate cancer.
UNC researchers use their new research platform to discover new cell subpopulations and crucial cellular players in the process of turning damaged heart tissue back into healthy heart muscle. The research platform could be used to study other biological processes and create tailored therapies.
In a new study published in Cell Systems, UNC Lineberger's Jeremy Purvis, PhD, and colleagues report that the timing of when DNA damage occurs within these different checkpoints matters to a cell’s fate.
UNC-Chapel Hill and UC-San Francisco scientists solved the crystal structure of a specific dopamine receptor called D4 at an incredibly high resolution and designed a new compound that tightly binds only to D4 and none of the other 320 receptors they tested.
Using laboratory equipment readily available in developing countries, researchers from UNC and Abbott Diagnostics were able to define and map the burden of hepatitis C virus for the first time in the Democratic Republic of the Congo. Their findings were published in Clinical Infectious Diseases.
The book, titled “Drinking, Drug Use and Addiction in the Autism Community,” explores why addiction is more common among individuals with ASD than it is within the general population and investigates how addiction and autism affect one another.
The UNC Center for Health Innovation is included in a new list of 58 Hospitals and Health Systems with Innovation Programs, published today by Becker’s Hospital Review.
During head injury, a common problem is damage to axons – long stalks that grow out of the bodies of neurons. After a strong jolt to the head, axons can break or swiftly degenerate. UNC’s Anne Taylor and colleagues have revealed new molecular details of this and a path toward repairing axons.
UNC-Chapel Hill has a new study in JAMA that challenges long-held practices of testing AMH and FSH levels to predict reproductive potential.
Researchers report in JAMA Dermatology that surgical treatment delays – defined as surgery that occurred more than six weeks after diagnosis – were common. Medicaid patients were 36 percent more likely than private insurance patients to experience delays.
Preliminary findings presented at this year’s American Society for Radiation Oncology Annual Meeting suggest a genetic test for HPV16 in the blood could be useful to help assess risk for patients, and could help identify patients suitable for lower treatment doses.
UNC School of Medicine cardiologist Anil Gehi, MD, will use a $1.7 million grant from the Bristol-Myers Squibb Foundation to further innovate a care model, launched in 2015, that reduced hospitalizations for patients with atrial fibrillation (Afib) presenting in the emergency room by more than 30 percentage points in its first year.
Scientists at the UNC School of Medicine and elsewhere are exploring ways to reprogram scar tissue cells into healthy heart muscle cells, and now UNC researchers have published the first scientific paper to compare in great detail the two leading reprogramming techniques.
Eva Anton’s lab at UNC has shown how the deletion of the protein APC in progenitor cells – which give rise to neurons – disrupts the Wnt protein pathway, which previously was linked to genes associated with autism.
In a study published in PLOS ONE, UNC School of Medicine researchers found that skills developed during science PhD programs translate to success in a wide range of fields.
The calculator estimates the impact of differences in breastfeeding rates, providing policy makers and advocates with ways to approximate return on investment for measures that help enable breastfeeding.
Cost savings fell below expectations for generic versions of an orally administered cancer treatment in an analysis by University of North Carolina Lineberger Comprehensive Cancer Center researchers. The findings raise questions about the extent to which generic drugs can help control care costs for cancer treatments.
Mucin levels – the proteins that make mucus thick – is abnormally high in chronic bronchitis and mucin concentrations are associated with disease severity. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.
Scientists have known that abnormal protein deposits and swarms of activated immune cells accumulate in brains of people with Alzheimer’s. Now researchers have untangled how these proteins and inflammation interact in lab experiments to reveal how therapies might reverse the disease process.
Working at a health center in rural Uganda, researchers from the University of North Carolina at Chapel Hill demonstrated for the first time the potential of using a low-cost, routinely available rapid diagnostic test to distinguish between severe and uncomplicated malaria in children.
A new imaging technique helps UNC researchers study tiny, time-sensitive biological processes – the crucial underpinnings of human health and disease.
Modern Healthcare has named Dr. William L. Roper, CEO of UNC Health Care, dean of the UNC School of Medicine and vice chancellor for medical affairs at the University of North Carolina at Chapel Hill, to its annual list of the 100 Most Influential People in Health Care for 2017.
UNC Lineberger scientists led a multi-institution research team to identify key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.
An antenna-like structure on cells, once considered a useless vestige, can cause defects in the brain’s wiring similar to what’s seen in autism, schizophrenia, and other disorders. In the lab, UNC scientists prevented defects by restoring signaling though these structures called primary cilia.
In the Journal of the National Cancer Institute, UNC Lineberger researchers published results of an analysis of approximately 1,000 invasive breast tumors. The study confirmed that young black women are more likely to have “triple negative,” or “basal-like,” breast cancers, a subtype that does not express any of the receptors for targeted biologic therapies. The study also identified variation by race within a clinical breast cancer type that has the greatest mortality disparity.
Researchers from UNC and NC State are developing a potential stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis – often-fatal conditions that affect tens of millions of Americans.
Researchers at the University of North Carolina at Chapel Hill have found Ebola RNA in the semen of survivors two years after infection. They are calling on the World Health Organization to update its guidelines on sexual transmission.
For the first time researchers at the University of North Carolina at Chapel Hill have developed an assay that can measure antigen production and clearance caused by a latency-reversing agent.
The National Institutes of Health has awarded the University of North Carolina more than $5.6 million to test a therapeutic vaccine for HIV. The study's principal investigator says the goals are to redirect and strengthen the immune response to the virus.
The protein TDP-43 is thought to cause muscle degeneration in patients with ALS. UNC and NC State researchers found that a specific chemical modification promotes TDP-43 clumping in animals. In muscle cells, scientists reversed protein clumping and prevented the sIBM-related muscle weakness.
Cancer drug Vorinostat given every 72 hours can awaken sleeping HIV in the body, says researchers at the University of North Carolina at Chapel Hill. However, it does not clear or deplete infection, meaning additional advances will be needed to achieve a cure.
Can the kinds of microbes colonizing the gut at age 1 predict later cognitive development? Findings from the UNC School of Medicine shed light on the surprising role of bacteria in how our brains develop during the first years of life.
UNC Health Care is one of only 27 systems in the United States to be recognized as a “Most Wired Advanced” health system by the American Hospital Association (AHA) for its use of information technology to improve patient care and clinical integration.
The William R. Kenan, Jr. Charitable Trust has awarded the School of Medicine at the University of North Carolina at Chapel Hill $1.5 million to establish interprofessional clinical experiences for health professions students in rural areas of the state, launching the UNC Rural Interprofessional Health Initiative (RIPHI).
In the journal Nature Nanotechnology, University of North Carolina Lineberger Comprehensive Cancer Center researchers report on strides made in the development of a strategy to improve the immune system's detection of cancer proteins by using “sticky” nanoparticles.
Technology invented in a laboratory in the UNC-NC State Joint Biomedical Engineering Program could soon mean painless diabetes testing and insulin injections for the nearly 400 million people with diabetes worldwide.
UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme called Set2 found in virtually all organisms other than bacteria. The basic science finding may have implications for understanding cancer development and how to halt it.
Researchers at the University of North Carolina School of Medicine announced the publication of results from a multi-site phase 2 clinical trial with brexanolone, an investigational medication, in the treatment of severe postpartum depression (PPD).
Scientists have known for decades that smoking cigarettes causes DNA damage, which leads to lung cancer. Now, for the first time, UNC School of Medicine scientists created a method for effectively mapping that DNA damage at high resolution across the genome.
In a landmark study, UNC School of Medicine researchers have shown that blood glucose testing does not offer a significant advantage in blood sugar control or quality of life for type 2 diabetes patients who are not treated with insulin.
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