The Broad Institute of MIT and Harvard announces the appointments of Chief Operating Officer Samantha Singer and Chief Communications Officer Clare Midgley to its senior leadership team. They join Chief Development Officer Justine Levin-Allerhand who was recruited to the Broad last year.
The Broad Institute today announced that the United States Patent and Trademark Office has issued the first patent for an engineered CRISPR-Cas9 system that is enabling scientists to modify genes and better understand the biology of living cells and organisms.
AstraZeneca and the Broad Institute in Cambridge, Massachusetts today announce a collaboration to identify new chemical compounds targeting bacterial and viral infections that could speed the development of new antibacterial and antiviral drugs.
Melanoma - the deadliest and most aggressive form of skin cancer - has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced the whole genomes of 25 metastatic melanoma tumors, confirming the role of chronic sun exposure and revealing new genetic changes important in tumor formation.
Neuroscientist and former head of the NIMH will be the Center’s new director
New space will adjoin existing building, consolidating operations and fueling scientific collaborations
The true power of genomic research lies in its ability to help scientists understand biological processes, particularly those that – when altered – can lead to disease. This power is demonstrated dramatically in a pair of papers published today in the journal Nature. In the first, a global team of researchers describes 95 different variations across the genome that contribute in different degrees to alterations in blood cholesterol and triglyceride levels in multiple human populations. In the second report, close examination of just one of these common variants not only reveals the involvement of an unexpected genetic pathway in lipid metabolism but also provides a blueprint for using genomic findings to unravel biological connections between lipid levels and coronary heart disease.
Large-scale study reveals DNA segments missing or duplicated in tumors, uncovers novel cancer genes and genetic abnormalities shared across cancers.
Mexican business leader Carlos Slim Helú today announced the launch of a major research project in genomic medicine that will help accelerate progress in public health in Mexico and around the world.
Fossils may provide tantalizing clues to human history but they also lack some vital information, such as revealing which pieces of human DNA have been favored by evolution because they confer beneficial traits — resistance to infection or the ability to digest milk, for example. Now, researchers describe a method for pinpointing these preferred regions that offers greater precision and resolution than ever before, and the possibility of deeply understanding both our genetic past and present.
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation. When the gene is missing from the donor’s genome but present in the recipient’s, transplants have a greater risk of a serious side-effect known as graft-versus-host disease, in which immune cells from the donor attack tissues in the recipient.
New molecule neutralizes key protein, once thought to be “undruggable,” with roles in leukemia and other cancers
An international team of researchers has decoded the genome of the domestic horse Equus caballus, revealing a genome structure with remarkable similarities to humans and more than one million genetic differences across a variety of horse breeds. In addition to shedding light on a key part of the mammalian branch of the evolutionary tree, the work also provides a critical starting point for mapping disease genes in horses.
In one of the first studies of its kind, an international team of researchers has uncovered a single-letter change in the genetic code that is associated with autism. The finding, published in the October 8 issue of the journal Nature, implicates a neuronal gene not previously tied to the disorder and more broadly, underscores a role for common DNA variation.
In a study published in the September 24th issue of Nature, an international team describes how they harnessed modern genomic technology to explore the ancient history of India, the world’s second most populous nation.
An international research team has decoded the genome of the notorious organism that triggered the Irish potato famine in the mid-19th century and now threatens this season’s tomato and potato crops across much of the US. The study reveals an unusually large genome size — more than twice that of closely related species — and an extraordinary genome structure, which together appear to enable the rapid evolution of genes, particularly those involved in plant infection.
Scientists have deciphered a key molecular circuit that enables the body to distinguish viruses from bacteria and other microbes, providing a deep view of how immune cells in mammals fend off different pathogens.
The Multiple Myeloma Research Foundation (MMRF) and the Broad Institute of MIT and Harvard launch a collaboration to systematically uncover the molecular changes underlying multiple myeloma by whole genome sequencing of individual patient tumors. The MMRF will provide initial resources and valuable multiple myeloma tumor samples.
Researchers have uncovered a vast new class of previously unrecognized mammalian genes that do not encode proteins, but instead function as long RNA molecules, and seem to play critical roles in both health and disease, including cancer, immune signaling and stem cell biology.
Scientists today announced the results of the largest genomic study to date of lung adenocarcinoma, the most common form of lung cancer. The researchers pinpointed a variety of genetic alterations in patient tumors, more than doubling the number of genes linked to the disease. Importantly, the work highlights key molecular defects in lung tumors that are often found in other forms of cancer, a convergence that could open important avenues for treatment.
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