Credit: Sanjay Jain, Johns Hopkins University School of Medicine.
Rabbits were infected with Mycobacterium tuberculosis leading to TB meningitis in the brain. The brain is shown in yellow with bacteria (red) in TB lesions. Inset: PET image of rabbit brain following injection of antibiotic, rifampin, into the rabbit’s circulation. Orange dots show the limited concentration of rifampin that penetrates the blood brain barrier and reaches the TB lesions in the brain.