Credit: Lab of Brian Brown, PhD, at Icahn Mount Sinai
One such tool, Perturb-map used above, created in the lab of Brian Brown, PhD, enables scientists to see how cancer genes affect not only cancer cells but also how they impact the immune system within tumors. In this case, tumors without the Tgfbr2 gene repel immune cells, while those lacking the Socs1 gene attract cancer-fighting T cells.